Objective The consortium assembled here will contribute to the development of new anti-inflammatory drugs for clinical use in the European Union and beyond by identifying medicinal plant extracts with NF-kappa inhibitory activity and/or inhibitory effects on targets of the inflammatory cascade in peripheral and CNStissues. These targets will include, for example, IL-1beta, TNFalpha, PGE2, and IL-6. Subsequently the compounds mediating this inhibitory effect will be isolated and their structure elucidated. The consortium has the capacity to evaluate the extracts in a large set of targets related to the transcriptional activation of gene products of relevance for inflammatory, immunomodulatory and apoptotic activity. Select compounds will be further studied in in-vivo as well as in-Microsystems and we expect that this research will form the basis for preclinical and clinical development. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF LONDON EU contribution No data Address MALET STREET, SENATE HOUSE WC1E7HU LONDON United Kingdom See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LIMITED United Kingdom EU contribution No data Address Gunnels Wood Road, Medicines Research Centre SG1 2NY STEVENAGE See on map Total cost No data THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT Israel EU contribution No data Address Ein Kerem Campus 91905 JERUSALEM See on map Total cost No data UNIVERSIDAD DE CORDOBA Spain EU contribution No data Address Avda Menendez Pidal s/n 14004 CORDOBA See on map Total cost No data UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE 'AMEDEO AVOGADRO' Italy EU contribution No data Address Via Ferrucci 33 28100 NOVARA See on map Total cost No data UNIVERSITAETSKLINIKUM FREIBURG Germany EU contribution No data Address Hauptstr. 5 79104 FREIBURG (IN BREISGAU) See on map Total cost No data UNIVERSITY OF BERNE Switzerland EU contribution No data Address 3,Freiestrasse 3 3012 BERN See on map Total cost No data UNIVERSITY OF KUOPIO Finland EU contribution No data Address 2,Neulaniementie 2 70211 KUOPIO See on map Total cost No data