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Treatment and prevention of bacterial infections by anti-adhesion compounds

Treatment and prevention of bacterial infections by anti-adhesion compounds

Objective

To combat the growing number of antibiotic-resistant bacteria new therapeutic strategies are needed. Our proposal aims to create novel therapeutics that can interfere with the adhesion of pathogenic bacteria to carbohydrate ligands present on target tissues. For many bacteria this event is the first and crucial step that leads to an infection. Since multiple copies of the bacterial receptors are present the optimal strategy is to use multiple copies of the carbohydrate, i. e. multivalency. This strategy can lead to dramatically enhanced binding compared to monovalent interactions. The specific carbohydrates will be synthesised chemically and will be coupled to novel multivalent backbone molecules. The molecules are evaluated in various adhesion assays and their applicability will be evaluated with relevant animal model studies. Our target pathogenic bacteria are H. pylori, E. coli, and S. suis.

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Coordinator

UTRECHT UNIVERSITY

Address

Sorbonnelaan 16
3584 Ca Utrecht

Netherlands

Administrative Contact

Monique DE VRIES (Ms)

Participants (4)

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STATENS SERUM INSTITUT

Denmark

UNIVERSITY OF MANCHESTER

United Kingdom

UNIVERSITY OF TURKU

Finland

UNIVERSITY OF WUERZBURG

Germany

Project information

Grant agreement ID: QLK2-CT-2002-01852

  • Start date

    1 May 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 798 721

  • EU contribution

    € 1 798 721

Coordinated by:

UTRECHT UNIVERSITY

Netherlands