Obiettivo VIRULENCE will provide a strategy against a major health threat: occurrence of resistance against therapeutic HIV/AIDS-measures. Reverse transcriptase inhibitors play an essential role HIV -treatment RT variants with reduced susceptibility to these inhibitors emerge even under potent combination therapies and may become less virulent. Thus, emergence of RTI resistance negatively affects the inhibitor efficacy but may also result in virus variants with reduced pathogenicity. VIRULENCE aims at elucidating clinical consequences of changes in viral fitness for optimal use of antiviral drugs. VIRULENCE is first to address this through development and validation of improved fitness assays and their application on existing well-defined longitudinal clinical cohorts. The mol. mechanisms for viral fitness and resistance will be elucidated and new compounds active against drug resistant HIV will be defined. This integrated approach will improve care of patients with limited therapeutic options. Campo scientifico natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programma(i) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Argomento(i) 1.1.1.-2. - Key action Control of Infectious Diseases Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY MEDICAL CENTRE UTRECHT Contributo UE Nessun dato Indirizzo Heidelberglaan 100 3584CX UTRECHT Paesi Bassi Mostra sulla mappa Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM Paesi Bassi Contributo UE Nessun dato Indirizzo MEIBERGDREEF 15 1105AZ AMSTERDAM Mostra sulla mappa Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Hopital Bichat-Claude Bernard, Rue H. Huchard 75018 PARIS Mostra sulla mappa Costo totale Nessun dato INTITUTE DE RECERCA DE LA SIDA Spagna Contributo UE Nessun dato Indirizzo Ctra de Canyet, s/n. University Hospital Germans T 08916 BADALONA Mostra sulla mappa Costo totale Nessun dato KATHOLIEKE UNIVERSITEIT LEUVEN Belgio Contributo UE Nessun dato Indirizzo 10,Minderbroedersstraat 10 3000 LOUVAIN / LEUVEN Mostra sulla mappa Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Regno Unito Contributo UE Nessun dato Indirizzo Roosevelt Drive Headington OX3 7BN OXFORD/HEADINGTON Mostra sulla mappa Costo totale Nessun dato THE UNIVERSITY OF MILANO Italia Contributo UE Nessun dato Indirizzo L. Sacco Hospital, Via GB Grassi 74 20157 MILANO Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ERLANGEN-NUREMBERG Germania Contributo UE Nessun dato Indirizzo 4,Schlossgarten 4 91054 ERLANGEN Mostra sulla mappa Costo totale Nessun dato
