New approaches to treatment and control of Lassa fever and Yellow fever in West Africa

Informazioni relative al progetto

TREATCONTROL-VHF

ID dell’accordo di sovvenzione: ICA4-CT-2002-10050

Progetto chiuso

Data di avvio 1 Gennaio 2003

Data di completamento 30 Giugno 2006

Finanziato da

• Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Costo totale € 1 230 465,00

Contributo UE € 994 131,00

Coordinato da

PHILIPPS UNIVERSITY MARBURG
Germany

Obiettivo

From survivors of LF or YF, combinatorial phage-display antibody libraries will be constructed and neutralizing antibodies will be selected. Recombinant antibodies will be used for studying the molecular mechanisms of virus neutralization and will be engineered for immunotherapy. Mastomys natalensis, the principal rodent vector of Lassa virus, appears to be a morphologically indistinguishable complex of subspecies in West Africa. We will develop cytogenetic and molecular techniques to differentiate these subspecies and correlate them with their vector capacity for Lassa virus. A better understanding of the vector biology of Mastomys may lead to new ecological approaches for the Control of LF. To improve YF surveillance in Africa, new PCR strategies will be developed to detect all recently described five genotypes of YF in pooled mosquitoes.

Campo scientifico

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › basic medicine › immunology › immunotherapy
• natural sciences › biological sciences › zoology › invertebrate zoology

Programma(i)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Argomento(i)

• 1.2.1.-1.4. - Research for development

Invito a presentare proposte

Data not available

Meccanismo di finanziamento

CSC - Cost-sharing contracts

Coordinatore

PHILIPPS UNIVERSITY MARBURG

• Contributo UE: Nessun dato
• Indirizzo: Robert Kochstrasse 17 ; 35037 MARBURG ; Germania
• Costo totale: Nessun dato

Partecipanti (4)

INSTITUT PASTEUR

Francia

• Contributo UE: Nessun dato
• Indirizzo: avenue Tony Garnier 21 ; 69365 LYON
• Costo totale: Nessun dato

INSTITUT PASTEUR DE COTE D'IVOIRE

Costa d’Avorio

• Contributo UE: Nessun dato
• Indirizzo: 01 ABIDJAN
• Costo totale: Nessun dato

MUSEUM NATIONAL D'HISTOIRE NATURELLE

Francia

• Contributo UE: Nessun dato
• Indirizzo: rue Buffon 55 ; 75005 PARIS
• Costo totale: Nessun dato

UNIVERSITE DONKA

Guinea

• Contributo UE: Nessun dato
• Indirizzo: CHU Donka ; CONAKRY
• Costo totale: Nessun dato