Objective
Mitotic errors and genome instability are major contributing factors to malignant transformation. Loss or gain of entire chromosomes, or stable chromosome fragments generated by all sorts of rearrangements, play an essential role in the unbalance of gene products that contributes to malignancy. The importance of aneuploidy in the progression of a cell to the cancerous state is well established. Aneuploidy can be generated by defects in either the kinetochore, the mitotic apparatus or the spindle checkpoint. Another mitotic structure that has been implicated in cancer etiology is the centrosome. Centrosome abnormalities have now been reported in many tumors and many oncogenes and tumor suppressor genes have been found to be associated with the centrosome at different stages of the cell cycle. Finally , it has been proposed that multinucleated cells produced by failure of cytokinesis would give rise to aneuploid mitotic products that would promote carcinogenesis The research to be undertaken is aimed at a further understanding of the molecular mechanisms that underlie genomic stability in higher eukaryotes.
The aim of this proposal is the study of the above topics using Drosophila melanogaster as a model organism. Using a variety of integrated genetic and biochemical approaches we plan to analyze
(1) the spindle checkpoint machinery,
(2) the regulation of centrosome activity,
(3) the centrosome and its interacting proteins and
(4) the mechanisms of cytokinesis. Given the high degree of evolutionary conservation of genes involved in cell division, our findings should provide the basis for identifying genes that govern the mitotic process in human cells. The discovery of such genes should extend our knowledge of cancer etiology and provide a potential basis for therapeutic intervention.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00185 ROMA
Italy
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