Objective The DLK1-GTL2 domain is a recently discovered,evolutionary served,H 1 Mb cluster of imprinted genes mapping to 14q32 in man,distal 12 in the mouse and distal 18q in sheep.It tains at least four protein encoding genes expressed from the paternal allele (DLK1,RTL1,DIO3 and BEGAIN),as well as a series of non coding RNA genes expressed from the maternal allele (e.g. GTL2, MEG8, MIRG).It was recently demonstrated that the DLK1-GTL2 domain tains multiple small non coding RNA genes.More specifically,it includes (i) a pair of miRNA genes (miR-127 and miR-136) antisense to RTL1, (ii) a clusters of H C/D snoRNA genes thought to be processed from the introns of the non coding MEG8 gene,and (iii) a cluster of H 40 miRNA genes thought to be processed from a large precursor transcript referred to as MIRG. Elucidating the biological function and mode of action of the miRNA genes in the DLK1-GTL2 domain is the topic of this proposal.More precisely,the objectives of the Callimir proposal are:(i) to study the role of the miR-127 and miR-136 genes in development and in regulating the expression of the RTL1 gene and (ii) to study the role of the MIRG cluster of miRNA genes in development and in mediating the trans effect underlying polar overdominance. Fields of science natural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological sciencesgeneticsgenomesnatural sciencescomputer and information sciencesinternetworld wide webnatural sciencesbiological sciencesmolecular biology Keywords callipyge imprinting micro RNA sno RNA Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator UNIVERSITÉ DE LIÈGE EU contribution No data Address 7 place du XX aout LIÈGE Belgium See on map Links Website Opens in new window Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address 3 rue Michel Ange PARIS See on map Links Website Opens in new window Total cost No data UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address Cambridge CAMBRIDGE See on map Links Website Opens in new window Total cost No data
