Objective
Filamentous fungi make a devastating impact on agriculture and human health. European agrochemical and medical drug discovery companies face a pressing need for safer and more effective products. The major bottleneck in the development of better antifungal s is the discovery of novel cellular targets. SIGNALPATH is a state-of-te-art post-genome project that used highly sophisticated and integrated genetic, genomic, and bioinformatic tools to sort through the large quantities of information available in genome databases, with the aim of elucidating complex biological pathways and pinpointing potential antifungal targets.
Our goal is to identify and validate fungal genes and proteins that play a causative role in disease and can be targeted for inhibition through the intervention of small molecules or antibodies. SIGNALPATH will focus on a set of conserved cellular signalling modules called mitogen-activated protein kinase (MAPK) cascades, which play pivotal roles during fungal infection.
A panel of multi-facete d approaches will be used to elucidate three key nodal points of fungal MAPK cascades whose role in disease is currently unknown:
[1] the signal inputs that activate the pathway,
[2] the upstream pathway receptors and
[3] the downstream effectors.
To fill the existing knowledge gap, SIGNALPATH reaches across the boundaries of traditionally separated fields such as plant pathology, medical mycology, biochemistry, cell cycle research and bioinformatics to gather a team of leading expert groups with a unique s kill-set in fungal biology, genetics and comparative genomics. The network integrated two world-class companies, Bayer CropScience, a global key player in plant protection and Novozymes, the world leader in microbial enzyme solutions. This dynamic interactive platform provides the scenario for training 6 ESRs and 3 ERs in a set of state-of-the-art skills encompassing fungal pathogenesis, cell signalling and antifungal discovery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- agricultural sciences agriculture, forestry, and fisheries agriculture agronomy plant protection
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences microbiology mycology
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CORDOBA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.