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Advanced signal-processing for ultra-fast magnetic resonance Spectroscopic Imaging, and Training

Objective

Magnetic Resonance Spectroscopic Imaging - MRSI - is an emerging, non-invasive modality of Molecular Imaging that opens the way to in vivo mapping of metabolism. It will greatly contribute to combating major diseases (cancer, Alzheimer's disease, multiple sclerosis, etc), monitoring therapy, drug development. Spin-offs: food inspection, materials research. Till today, major obstacles to routine clinical applications of MRSI are
1) Long measurement time, several minutes minimal,
2) Low spatial resolution and low signal-to-noise ratio of metabolic images,
3) Considerable complexity of MRSI processing, analysis, and data visualization,
4) Sparseness of training facilities. Exploiting the strong synergy between signal processing and MR methodology, this proposal aims to pave the way to real-time MRSI. This involves - Cutting-edge MRSI signal-processing algorithms for quantitation and imaging of metabolites.
This includes - A 'Virtual Scanner' based on Quantum Mechanics - Advanced Semiparametric Estimation - Innovative Graphical User-Interfacing - Ultra-fast Data Acquisition at the forefront of MR-methodology. - Innovative e-Training/ToK for young researchers and experts. FAST will contribute to establishing MRSI as non-invasive routine tool in the clinic for combating major diseases. An ultimate goal is MRSI during surgery. An innovative graphical user-interface with web-collaboration will enable interactive communication sessions, with data- and action-sharing, between multiple users. FAST is interdisciplinary and intersectorial and lends itself very well for Training/ToK in all facets of MRSI, with advanced interactive web-based and traditional methods. Partner expertise ranges from medicine to theoretical physics, via biochemistry, chemistry, physics, signal processing, informatics, numerical algebra, and encompasses four Industries. Our joint effort will make MRSI a reliable, ultra-fast, non-invasive, metabolite monitor for the clinic.

Call for proposal

FP6-2005-MOBILITY-1
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Funding Scheme

RTN - Marie Curie actions-Research Training Networks

Coordinator

UNIVERSITE CLAUDE BERNARD LYON 1
Address
43, Boulevard Du 11 Novembre 1918
Villeurbanne
France

Participants (16)

THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven
UNIVERSITAET LEIPZIG
Germany
Address
Ritterstrasse 26
Leipzig
INSTITUTE FOR LANGUAGE AND SPEECH PROCESSING
Greece
Address
Artemidos 6 & Epidavrou
Maroyssi
TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CHALDIKA
Greece
Address
Psachna Evoias
Chalkida
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
1 Place De L'universite
Louvain-la-neuve
UNIVERSITAT AUTONOMA DE BARCELONA
Spain
Address
Campus Uab
Bellaterra (Cerdanyola Del Valles)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Geerd Grooteplein-noord 9
Nijmegen
USTAV PISTROJOVE TECHNIKY, AKADEMIE VD ESKE REPUBLIKY
Czechia
Address
Kralovopolska 147
Brno
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address

Lausanne
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Netherlands
Address
Veenpluis, 4-6
PB 10000 Best
SIEMENS AG
Germany
Address
Wittelsbacherplatz 2
Muenchen
SANOFI-AVENTIS DEUSTSCHLAND GMBH
Germany
Address
Industrial Park Hoechst Building G 879
Frankfurt
ALTER SYSTEMS
France
Address
174 Chemin De Choulans
Lyon
EZUS LYON 1 SA
France
Address
43, Boulevard Du 11 Novembre 1918, Batiment L'atrium
Villeurbanne
LYON INGÉNIERIE PROJETS
France
Address
43 Boulevard Du 11 Novembre 1918
Villeurbanne