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Influence of the dietary history in the prevention of coeliac disease: possibilities of induction of tolerance for gluten in genetic predisposed children

Obiettivo

Coeliac disease (CD) is a chronic disorder caused by hypersensitivity to some of the most common proteins (gluten) in the diet of the European population. CD affects as much as 1% of the Europeans (2.5 million people) and is the most common food intolerance in Europe. If recognised, CD patients have only limited access to safe foods and there is no causal therapy available.

The general objective of this STREP is to significantly reduce the number of people suffering from CD in Europe, by developing primary prevention strategies for CD. By European collaboration of leaders from disciplines beyond those traditionally used, a.o. from academia, patient organisations and industry, we will carry out innovative research to examine the hypothesis that it is possible to induce tolerance for gluten in genetically predisposed children through the introduction of small quantities of gluten during the period of breast-feeding.

Measurable objectives are:
1) Taking full advantage of genomics techniques: Identification of the immunological mechanisms involved in initiating the aberrant response to gluten introduction in the diet of infants genetically predisposed to CD;
2) Identification of the factors in the early dietary history involved in the aberrant response to gluten in children;
3) Development of new European guidelines for early nutrition in order to prevent CD.

To achieve our objectives we propose the following structure and methodology:
I) A prospective, randomised, blind dietary intervention study in 1000 young children from high-risk families for CD, to asses the possibilities to induce immune tolerance for gluten in genetically predisposed children;
II) A follow-up population study in 16.000 children aged 12 years, born during and after the Swedish epidemic of CD, to asses the late effect of dietary history, concerning gluten exposure and breast-feeding, on the development of CD and related autoimmune phenomena.

Programma(i)

Argomento(i)

Invito a presentare proposte

FP6-2005-FOOD-4-B
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Meccanismo di finanziamento

STREP - Specific Targeted Research Project

Coordinatore

ACADEMISCH ZIEKENHUIS LEIDEN ACTING UNDER THE NAME LEIDS UNIVERSITAIR MEDISCH CENTRUM
Contributo UE
Nessun dato
Indirizzo
Albinusdreef 2
9600 LEIDEN
Paesi Bassi

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Partecipanti (13)

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Ultimo aggiornamento: 24 Gennaio 2011

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Permalink: https://cordis.europa.eu/project/id/036383/it

European Union, 2024