Objective Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular disease. In addition, radiation may increase atherosclerotic lesions in the coronary arteries. The aim of this collaborative research project is to elucidate the pathogenesis of early and late alteration in the microcirculation of the heart and of atherosclerotic lesions in arteries after exposure to low radiation doses in comparison to high radiation doses. A major goal will be the investigation of early molecular, proinflammatory and prothrombotic changes as well as perfusion alteration, cardiac cell integrity and immunologic influences. To achieve this goal, in vivo as well as ex vivo and in vitro studies will be performed. A central component of the project will be the local irradiation of the heart with subsequent isolation of cardiomyocytes and cardiac endothelial cells to provide all participating groups with the same biological material for further study. In addition, structural, morphological and molecular studies will be complemented by functional assays and imaging methods. Fields of science social sciencessociologydemographymortalitymedical and health sciencesclinical medicinecardiologycardiovascular diseases Keywords cardiovascular disease endothelial cell integrity in vitro in vivo radiation protection Programme(s) FP7-EURATOM-FISSION - EURATOM: Nuclear fission and radiation protection Topic(s) Fission-2007-3.1-01 - Non-cancer effects Call for proposal FP7-Fission-2007 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN EU contribution € 437 794,00 Address ISMANINGER STRASSE 22 81675 Muenchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Claudia Speiser (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all TECHNISCHE UNIVERSITAET DRESDEN Germany EU contribution € 439 410,00 Address HELMHOLTZSTRASSE 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Wolfgang Dörr (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 239 843,00 Address PLESMANLAAN 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE France EU contribution € 234 919,00 Address AV DE LA DIVISION LECLERC 31 92260 Fontenay Aux Roses See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Research Organisations Administrative Contact Marie-Catherine Vozenin-Brotons (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE QUEEN'S UNIVERSITY OF BELFAST United Kingdom EU contribution € 162 941,00 Address UNIVERSITY ROAD LANYON BUILDING BT7 1NN Belfast See on map Region Northern Ireland Northern Ireland Belfast Activity type Higher or Secondary Education Establishments Administrative Contact Colleen Spence (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF SHEFFIELD United Kingdom EU contribution € 196 484,00 Address FIRTH COURT WESTERN BANK S10 2TN Sheffield See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NARODOWY INSTYTUT ONKOLOGII IM. MARII SKLODOWSKIEJ-CURIE -PANSTWOWY INSTYTUT BADAWCZY Poland EU contribution € 102 000,00 Address UL. W K ROENTGENA 5 02-781 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Administrative Contact Piotr Widlak (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Germany EU contribution € 196 912,00 Address INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg See on map Region Bayern Oberbayern München, Landkreis Activity type Research Organisations Administrative Contact Juergen Ertel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET LEIPZIG Germany EU contribution € 196 219,00 Address RITTERSTRASSE 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Ulrich Roessler (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SATEILYTURVAKESKUS Finland EU contribution € 200 150,00 Address JOKINIEMENKUJA 1 01370 Vantaa See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Jaana Mannonen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT MAASTRICHT Netherlands EU contribution € 291 636,00 Address MINDERBROEDERSBERG 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Administrative Contact Rob Van Der Zander (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Germany EU contribution € 112 400,00 Address OSKAR VON MILLER RING 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET ROSTOCK Germany EU contribution € 49 189,00 Address UNIVERSITATSPLATZ 1 18055 Rostock See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Rostock, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Margitta Paucker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
