Objective
Multiple Sclerosis (MS) is one the most important neurological diseases by virtue of its frequency, chronicity and tendency to attack young adults. Cognitive impairment may affect approximately all patients with MS, and has been reported to negatively impact employment, social functioning, quality of life, and the ability to perform instrumental activities of daily living, with a high social cost. Nowadays, the way the brain of people affected with MS perform a cognitive task is an enigma still unsolved. On the other hand, the integration of simultaneous event-related potentials (ERP) and functional magnetic resonance imaging (fMRI) is an emerging method in human brain mapping. Combining their complementary information both methods provide electrophysiological cerebral activity with high temporal resolution and hemodynamic response with high spatial resolution. Our purpose in this research will be to improve the assessment of cognitve dysfunction among MS patients with different stages of the disease using the simultaneous acquisition of ERP/fMRI to obtain physiological and pathological brain activity. In addiction, this temporal-spatial information will be correlated with diffusion tensor imaging (DTI) scores, a new imaging method that provide markers to assess the macroscopic and microscopic pathology. We have developed a detailed work plan including a first phase to verify the feasibility of co-recording of EEG and fMRI signals and a spatial-temporal description of the processing of stimuli. Thus, these achievements will allow us to obtain a powerful approach to assess performace of cognitive task in MS patients and further application in other neurolical disorders. Results of our ERP/fMRI study will provide unique insights on cognitive function in MS patients with different stages of the disease and the underlying neural basis, providing the first systematic investigation of simultaneous ERP/fMRI recording in these patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine pathology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- social sciences economics and business business and management employment
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20132 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.