Objective The DIVINOCELL project will identify novel Gram-negative targets by exploiting the components of the divisome, their activities and interactions. It will also design selective assays for screening and will obtain a new class of antimicrobials: compounds to block bacterial division. New medicines to attack Gram-negative pathogens will decrease the burden of infectious disease and have a highly beneficial social and economic impact in Europe and beyond. Cell division is an essential and still underexploited process with excellent properties to yield new inhibitors to attack infection by blocking the proliferation of pathogens. Inhibitors directed against bacterial division targets, that are not present in eukaryotic cells, will be both effective and innocuous to humans and animals. In addition, as many of their structures will be based on interaction domains and synthetic scaffolds, they will generate resistance at levels lower than the present antibiotics. DIVINOCELL will apply existing and new knowledge on the molecular biology of Gram-negative cell division as well as novel analytical (nanodiscs), bioinformatic (molecular dynamics), structural (membrane protein crystals) and imaging (lanthanide staining) tools to exploit in the test tube the structures and interactions of targets in the divisome and the septum. DIVINOCELL will develop potent systematic screening assays and will use them to select compounds specifically tailored to inhibit the division of Gram-negatives (not precluding broad spectrum ones). Secondary activity and cell assays, based on the properties of bacterial division, will be generated to validate hits and advance them to leads. The medicinal properties of selected leads will be improved. The translational steps of the project will be developed by 4 SMEs in close collaboration with the 8 academic partners having well-proven expertise in molecular microbiology, protein chemistry, structural biology, biophysics, imaging and bioinformatics. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological sciencesmolecular biologystructural biology Keywords E Gram-negatives anti-infectives coli evolutionary genetic chemistry molecular dynamics nucleotide-binding sites peptidoglycan protein interactions septation synthetic scaffolds Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.1-1 - Novel targets for drugs against Gram negative bacteria Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS EU contribution € 1 231 767,00 Address CALLE SERRANO 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Alberto Sereno Alvarez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOMOL-INFORMATICS SL Spain EU contribution € 409 100,00 Address CALLE FARADAY -Parque Cientifico- 28049 MADRID See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Milagros Ruiz Del Peso (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 346 630,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Liliane Flabbée (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EVOLVA BIOTECH A/S Denmark EU contribution € 673 160,00 Address LERSO PARKALLE 42-44 2100 Copenhagen Ø See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Pedersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 522 039,00 Address 20 Park Crescent W1B 1AL LONDON See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Elizabeth Culter (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEMURIS LIMITED United Kingdom EU contribution € 489 700,00 Address c/o FEL ACCOUNTS, THE CRESCENT 23 NE26 2JG WHITLEY BAY See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Phillip Elstob (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE CHILE Chile EU contribution € 153 201,00 Address Av. Libertador Bernardo O'Higgins 1058 10 Santiago See on map Activity type Higher or Secondary Education Establishments Administrative Contact Pedro Arancibia (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution € 722 144,00 Address KINGS GATE NE1 7RU Newcastle Upon Tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Nicola Place (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 627 501,00 Address SPUI 21 1012WX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Allard De Haart (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VICHEM CHEMIE KUTATO KORLATOLT FELELOSSEGU TARSASAG Hungary EU contribution € 333 940,00 Address VIOLA UTCA 2 8200 VESZPREM See on map Region Dunántúl Közép-Dunántúl Veszprém Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Zoltán Dobai (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG Netherlands EU contribution No data Address De Boelelaan 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Jaap Roos (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING VU Netherlands EU contribution € 446 904,00 Address DE BOELELAAN 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Yvonne Kops (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
