Skip to main content
Go to the home page of the European Commission (opens in new window)
English en
CORDIS - EU research results
CORDIS
Content archived on 2024-05-27

Nanosensors to monitor metal dynamics in living plant cells

Objective

Metals, such as manganese or zinc, are vital elements for plant growth and development. They are involved in many biological processes and one third of characterized enzymes are metalloproteins. Because metal excess or metal deprivation is deleterious for cells, plants have developed mechanisms to regulate the uptake, the transport and the storage of metals. Dr Thomine’s group, in Gif-sur-Yvette (France), has obtained evidence that metal compartmentalization is essential for metal homeostasis. However, no tools are currently available to monitor the dynamics of metal concentrations in living plants. Prof Frommer’s group, in Stanford (USA), pioneered the design of genetically encodable FRET nanosensors for living cells. The project will aim at developing a set of metal nanosensors to image in vivo the dynamics of manganese and zinc localization and their regulation in Arabidopsis thaliana. An integrated approach in plants, combining the use of mutants impaired in metal transport and metal imaging, will enable us to further understand biological processes underlying the control of metal homeostasis in plants. This project will enable the researcher to acquire new expertise in the design of nanosensors for living cells.

Fields of science (EuroSciVoc)

Keywords

Topic(s)

Call for proposal

FP7-PEOPLE-2007-4-1-IOF
See other projects for this call

Funding Scheme

MC-IOF - International Outgoing Fellowships (IOF)

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
EU contribution
€ 230 963,71
Address
RUE MICHEL ANGE 3
75794 Paris
France
Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Links
Total cost
No data