Objective
My objective is to understand how localized cortical actin/myosin contractility in individual cells within the Drosophila wing hinge and wing blade combine to generate the epithelial remodelling and convergence-extension movements that occur throughout the tissue. In particular, I will examine the role of the planar cell polarity proteins in generating and/or responding to these forces and test the hypothesis that convergence-extension movements are driven by external stretching forces caused by hinge contraction. To do so, I will use a multidisciplinary approach, including both genetics and biophysics. I will combine the genetic tools of Drosophila, to manipulate gene activity in time and space, with long-term time lapse imaging and automated image analysis, developed only recently in the Eaton lab, to quantitatively describe the effects of genetically induced cortical perturbations on cell behaviour. I will myself develop a completely novel method to exert controllable forces on wing tissue in vivo by directing the production of magnetic nanoparticles in specific regions of the wing. The originality of this project lies not only in its conceptual novelty, but in the powerful combination these methods and physical modelling that will be exploited to address the problem.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology cell polarity
- natural sciences biological sciences biophysics
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.