Locally generated forces within an epithelium: how do they affect the morphogenesis and planar cell polarity?

Informations projet

DROSOFORCESPOLARITY

N° de convention de subvention: 234841

Projet clôturé

Date de début 1 Avril 2009

Date de fin 31 Mars 2011

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total Aucune donnée

Contribution de l’UE € 169 284,33

Coordonné par

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Allemagne

Objectif

My objective is to understand how localized cortical actin/myosin contractility in individual cells within the Drosophila wing hinge and wing blade combine to generate the epithelial remodelling and convergence-extension movements that occur throughout the tissue. In particular, I will examine the role of the planar cell polarity proteins in generating and/or responding to these forces and test the hypothesis that convergence-extension movements are driven by external stretching forces caused by hinge contraction. To do so, I will use a multidisciplinary approach, including both genetics and biophysics. I will combine the genetic tools of Drosophila, to manipulate gene activity in time and space, with long-term time lapse imaging and automated image analysis, developed only recently in the Eaton lab, to quantitatively describe the effects of genetically induced cortical perturbations on cell behaviour. I will myself develop a completely novel method to exert controllable forces on wing tissue in vivo by directing the production of magnetic nanoparticles in specific regions of the wing. The originality of this project lies not only in its conceptual novelty, but in the powerful combination these methods and physical modelling that will be exploited to address the problem.

Champ scientifique (EuroSciVoc)

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• sciences naturelles › sciences biologiques › génétique
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines
• sciences naturelles › sciences biologiques › biologie cellulaire › polarité cellulaire
• sciences naturelles › sciences biologiques › biophysique
• ingénierie et technologie › nanotechnologie › nanomatériaux

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Mots‑clés

• Actin cytoskeleton
• Biophysics
• Genetically modified Drosophila
• Morphomechanics
• Myosin
• Planar cell polarity
• Tissue morphogenesis

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development"

Appel à propositions

FP7-PEOPLE-IEF-2008
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Régime de financement

MC-IEF -

Coordinateur

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

• Contribution de l’UE: € 169 284,33
• Adresse: HOFGARTENSTRASSE 8 ; 80539 Munchen ; Allemagne
• Région: Bayern › Oberbayern › München, Kreisfreie Stadt
• Type d’activité: Organismes de recherche
• Coût total: Aucune donnée