Objective
Tunneling nanotubes (TNTs), recently discovered thin membrane channels connecting distant cells, represent the underlying structure of a previously unrecognized type of cell-to-cell communication. To date, a growing number of cell types have been found to use TNTs for the intercellular exchange of diverse cargoes ranging from cytoplasmic signalling molecules such as calcium ions to small vesicles of endocytic origin. During the past year, pathogens such as the human immunodeficiency virus and prions were also found to spread TNT-dependently between cells. Given the emerging wide range of implications of TNTs in the field of biomedical research, it is important to first learn the basic principles and mechanisms of TNT-dependent cell-to-cell interactions. I therefore propose to focus on three major questions: First, I will characterize the type of endocytic vesicles transiting through TNTs using flow cytometry and quantitative live cell imaging to monitor the transfer of endosomal markers (Rab GTPases) through TNTs. Secondly, using the same methodological approach, I will analyze which myosin motor(s) is (are) involved in the active transport of vesicles through TNTs. Third, by employing a proteomic screen assay, I aim at characterizing the entire set of proteins/signalling molecules transferred through TNTs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
5020 Bergen
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.