Objective
The circadian clock generates and regulates many daily physiological and behavioural rhythms and thereby also influences the health of the organism. This knowledge has been useful for treating various diseases including cancer. In cancer therapy, survival rate and secondary effects can be improved by applying the treatment at the right time of day. However, the mechanisms by which the clock influences cancer development and treatment effects are not well understood. In the outgoing phase of the grant I will study how the functionality of circadian clocks in tumor and healthy tissue influences tumor development and response to treatment in Dr. Antoch’s research group at the Roswell Cancer Institute in Buffalo, USA. I will use a unique mouse model which allows visualization of the clock in real time by using bioluminescence imaging technology. I will study in vivo how changes in the clock relate to tumor development. I will further experimentally regulate the expression of clock genes to investigate how disrupting the clock affects tumor development both in vitro, using cell lines, and in vivo, by inoculating healthy mice with manipulated tumors. In a final step, in the return phase of the grant I will work together with Dr. Selivanova at the Karolinska Institutet in Stockholm, Sweden where I will test how potential anticancer drugs interact with the circadian clock and the apoptosis pathway.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.