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ToxBank – Supporting Integrated Data Analysis and Servicing of Alternative Testing Methods in Toxicology

Objective

ToxBank establishes a dedicated web-based warehouse for toxicity data management and modelling, a ‘gold standards’ compound database and repository of selected test compounds, and a reference resource for cells, cell lines and tissues of relevance for in vitro systemic toxicity research carried out across the FP7 HEALTH.2010.4.2.9 Alternative Testing Strategies SEURAT program. The project develops infrastructure and service functions to create a sustainable predictive toxicology support resource going beyond the lifetime of the program.
The following activities will be carried out:
a) Establishment of a dedicated web-based data warehouse
The ToxBank Data Warehouse will establish a centralised compilation of data for systemic toxicity. Data generated under the research program and additional public data will be uploaded and integrated whenever possible into computerised models capable of predicting repeated-dose toxicity.
b) Establishment of a database of test compounds
The ToxBank Gold Compound Database will provide a high quality information resource servicing the selection and use of test compounds. Chemicals in this database will be supported by high-quality repeated-dose toxicity in vivo and in vitro data, property data and, whenever available, human adverse event and epidemiological data. Selected test compounds for training or validation, and standard operating procedures for data quality control, processing and analyses will be provided.
c) Establishment of a repository for the selected test compounds
The ToxBank Chemical Repository will ensure the availability of test compounds to program researchers accompanied by sample preparation, handling and analytical quality control procedures.
d) Setting up of a cell and tissue banking information resource for in vitro toxicity testing
ToxBank will establish a banking information resource for access to qualified cells, cell lines (including stem cells and stem cell lines) and tissues and reference materials to be used for in vitro predictive toxicology research and testing activities.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/basic medicine/toxicology
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

FP7-HEALTH-2010-Alternative-Testing
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Address
Via Mario Negri 2
20156 Milano
Italy
Activity type
Research Organisations
EU contribution
€ 250 316
Administrative Contact
Emilio Benfenati (Dr.)

Participants (9)

DOUGLAS CONNECT
Switzerland
Address
Baermeggenweg
4314 Zeiningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barry Hardy (Dr.)
Leadscope, Inc.
United States
EU contribution
€ 194 240
Address
Dublin Road 1393
43215 Columbus
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Glenn Myatt (Dr.)
IDEACONSULT LIMITED LIABILITY COMPANY
Bulgaria
EU contribution
€ 195 920
Address
Angel Kanchev 4
1000 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vedrin Jeliazkov (Mr.)
Public Health England an Executive Agency of the Dept of Health
United Kingdom
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Amanda King (Ms.)
PHARMATROPE
United States
EU contribution
€ 125 440
Address
Croton Road 324
19087 Wayne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jeffrey Wiseman (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 150 320
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Per-Olof Larsson (Mr.)
IN SILICO TOXICOLOGY GMBH
Switzerland
EU contribution
€ 202 800
Address
Altkircherstrasse 4
4054 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christoph Helma (Dr.)
EDELWEISS CONNECT GMBH
Switzerland
EU contribution
€ 296 300
Address
Hochbergerstrasse 60C
4057 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barry Hardy (Dr.)
Department of Health
United Kingdom
EU contribution
€ 149 660
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Amanda King (Ms.)