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ToxBank – Supporting Integrated Data Analysis and Servicing of Alternative Testing Methods in Toxicology

ToxBank – Supporting Integrated Data Analysis and Servicing of Alternative Testing Methods in Toxicology

Objective

ToxBank establishes a dedicated web-based warehouse for toxicity data management and modelling, a ‘gold standards’ compound database and repository of selected test compounds, and a reference resource for cells, cell lines and tissues of relevance for in vitro systemic toxicity research carried out across the FP7 HEALTH.2010.4.2.9 Alternative Testing Strategies SEURAT program. The project develops infrastructure and service functions to create a sustainable predictive toxicology support resource going beyond the lifetime of the program.
The following activities will be carried out:
a) Establishment of a dedicated web-based data warehouse
The ToxBank Data Warehouse will establish a centralised compilation of data for systemic toxicity. Data generated under the research program and additional public data will be uploaded and integrated whenever possible into computerised models capable of predicting repeated-dose toxicity.
b) Establishment of a database of test compounds
The ToxBank Gold Compound Database will provide a high quality information resource servicing the selection and use of test compounds. Chemicals in this database will be supported by high-quality repeated-dose toxicity in vivo and in vitro data, property data and, whenever available, human adverse event and epidemiological data. Selected test compounds for training or validation, and standard operating procedures for data quality control, processing and analyses will be provided.
c) Establishment of a repository for the selected test compounds
The ToxBank Chemical Repository will ensure the availability of test compounds to program researchers accompanied by sample preparation, handling and analytical quality control procedures.
d) Setting up of a cell and tissue banking information resource for in vitro toxicity testing
ToxBank will establish a banking information resource for access to qualified cells, cell lines (including stem cells and stem cell lines) and tissues and reference materials to be used for in vitro predictive toxicology research and testing activities.

Coordinator

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Address

Via Giuseppe La Masa 19
20156 Milano

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 250 316

Administrative Contact

Emilio Benfenati (Dr.)

Participants (9)

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DOUGLAS CONNECT

Switzerland

Leadscope, Inc.

United States

EU Contribution

€ 194 240

IDEACONSULT LIMITED LIABILITY COMPANY

Bulgaria

EU Contribution

€ 195 920

Public Health England an Executive Agency of the Dept of Health

United Kingdom

PHARMATROPE

United States

EU Contribution

€ 125 440

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 150 320

IN SILICO TOXICOLOGY GMBH

Switzerland

EU Contribution

€ 202 800

EDELWEISS CONNECT GMBH

Switzerland

EU Contribution

€ 296 300

Department of Health

United Kingdom

EU Contribution

€ 149 660

Project information

Grant agreement ID: 267042

Status

Closed project

  • Start date

    1 January 2011

  • End date

    31 December 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 129 992

  • EU contribution

    € 1 564 996

Coordinated by:

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy