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ToxBank – Supporting Integrated Data Analysis and Servicing of Alternative Testing Methods in Toxicology

Objectif

ToxBank establishes a dedicated web-based warehouse for toxicity data management and modelling, a ‘gold standards’ compound database and repository of selected test compounds, and a reference resource for cells, cell lines and tissues of relevance for in vitro systemic toxicity research carried out across the FP7 HEALTH.2010.4.2.9 Alternative Testing Strategies SEURAT program. The project develops infrastructure and service functions to create a sustainable predictive toxicology support resource going beyond the lifetime of the program.
The following activities will be carried out:
a) Establishment of a dedicated web-based data warehouse
The ToxBank Data Warehouse will establish a centralised compilation of data for systemic toxicity. Data generated under the research program and additional public data will be uploaded and integrated whenever possible into computerised models capable of predicting repeated-dose toxicity.
b) Establishment of a database of test compounds
The ToxBank Gold Compound Database will provide a high quality information resource servicing the selection and use of test compounds. Chemicals in this database will be supported by high-quality repeated-dose toxicity in vivo and in vitro data, property data and, whenever available, human adverse event and epidemiological data. Selected test compounds for training or validation, and standard operating procedures for data quality control, processing and analyses will be provided.
c) Establishment of a repository for the selected test compounds
The ToxBank Chemical Repository will ensure the availability of test compounds to program researchers accompanied by sample preparation, handling and analytical quality control procedures.
d) Setting up of a cell and tissue banking information resource for in vitro toxicity testing
ToxBank will establish a banking information resource for access to qualified cells, cell lines (including stem cells and stem cell lines) and tissues and reference materials to be used for in vitro predictive toxicology research and testing activities.

Appel à propositions

FP7-HEALTH-2010-Alternative-Testing
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Coordinateur

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Adresse
Via Mario Negri 2
20156 Milano
Italie
Type d’activité
Research Organisations
Contribution de l’UE
€ 250 316
Contact administratif
Emilio Benfenati (Dr.)

Participants (9)

DOUGLAS CONNECT
Suisse
Adresse
Baermeggenweg
4314 Zeiningen
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Barry Hardy (Dr.)
Leadscope, Inc.
États-Unis
Contribution de l’UE
€ 194 240
Adresse
Dublin Road 1393
43215 Columbus
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Glenn Myatt (Dr.)
IDEACONSULT LIMITED LIABILITY COMPANY
Bulgarie
Contribution de l’UE
€ 195 920
Adresse
Angel Kanchev 4
1000 Sofia
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Vedrin Jeliazkov (Mr.)
HEALTH PROTECTION AGENCY HPA
United Kingdom
Adresse
Buckingham Palace Road 151
SW1W 9SZ London
Type d’activité
Research Organisations
Contact administratif
Amanda King (Ms.)
PHARMATROPE
États-Unis
Contribution de l’UE
€ 125 440
Adresse
Croton Road 324
19087 Wayne
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jeffrey Wiseman (Dr.)
KAROLINSKA INSTITUTET
Suède
Contribution de l’UE
€ 150 320
Adresse
Nobels Vag 5
17177 Stockholm
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Per-Olof Larsson (Mr.)
IN SILICO TOXICOLOGY GMBH
Suisse
Contribution de l’UE
€ 202 800
Adresse
Altkircherstrasse 4
4054 Basel
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Christoph Helma (Dr.)
EDELWEISS CONNECT GMBH
Suisse
Contribution de l’UE
€ 296 300
Adresse
Hochbergerstrasse 60C
4057 Basel
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Barry Hardy (Dr.)
Department of Health
United Kingdom
Contribution de l’UE
€ 149 660
Adresse
Quarry House, Quarry Hill
LS2 7UE Leeds
Type d’activité
Research Organisations
Contact administratif
Amanda King (Ms.)