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ToxBank – Supporting Integrated Data Analysis and Servicing of Alternative Testing Methods in Toxicology

Cel

ToxBank establishes a dedicated web-based warehouse for toxicity data management and modelling, a ‘gold standards’ compound database and repository of selected test compounds, and a reference resource for cells, cell lines and tissues of relevance for in vitro systemic toxicity research carried out across the FP7 HEALTH.2010.4.2.9 Alternative Testing Strategies SEURAT program. The project develops infrastructure and service functions to create a sustainable predictive toxicology support resource going beyond the lifetime of the program.
The following activities will be carried out:
a) Establishment of a dedicated web-based data warehouse
The ToxBank Data Warehouse will establish a centralised compilation of data for systemic toxicity. Data generated under the research program and additional public data will be uploaded and integrated whenever possible into computerised models capable of predicting repeated-dose toxicity.
b) Establishment of a database of test compounds
The ToxBank Gold Compound Database will provide a high quality information resource servicing the selection and use of test compounds. Chemicals in this database will be supported by high-quality repeated-dose toxicity in vivo and in vitro data, property data and, whenever available, human adverse event and epidemiological data. Selected test compounds for training or validation, and standard operating procedures for data quality control, processing and analyses will be provided.
c) Establishment of a repository for the selected test compounds
The ToxBank Chemical Repository will ensure the availability of test compounds to program researchers accompanied by sample preparation, handling and analytical quality control procedures.
d) Setting up of a cell and tissue banking information resource for in vitro toxicity testing
ToxBank will establish a banking information resource for access to qualified cells, cell lines (including stem cells and stem cell lines) and tissues and reference materials to be used for in vitro predictive toxicology research and testing activities.

Zaproszenie do składania wniosków

FP7-HEALTH-2010-Alternative-Testing
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

CP-IP - Large-scale integrating project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Koordynator

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Adres
Via Mario Negri 2
20156 Milano
Włochy
Rodzaj działalności
Research Organisations
Wkład UE
€ 250 316
Kontakt administracyjny
Emilio Benfenati (Dr.)

Uczestnicy (9)

DOUGLAS CONNECT
Szwajcaria
Adres
Baermeggenweg
4314 Zeiningen
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Barry Hardy (Dr.)
Leadscope, Inc.
Stany Zjednoczone
Wkład UE
€ 194 240
Adres
Dublin Road 1393
43215 Columbus
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Glenn Myatt (Dr.)
IDEACONSULT LIMITED LIABILITY COMPANY
Bułgaria
Wkład UE
€ 195 920
Adres
Angel Kanchev 4
1000 Sofia
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Vedrin Jeliazkov (Mr.)
Public Health England an Executive Agency of the Dept of Health
United Kingdom
Adres
Waterloo Road
SE1 8UG London
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Amanda King (Ms.)
PHARMATROPE
Stany Zjednoczone
Wkład UE
€ 125 440
Adres
Croton Road 324
19087 Wayne
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Jeffrey Wiseman (Dr.)
KAROLINSKA INSTITUTET
Szwecja
Wkład UE
€ 150 320
Adres
Nobels Vag 5
17177 Stockholm
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Per-Olof Larsson (Mr.)
IN SILICO TOXICOLOGY GMBH
Szwajcaria
Wkład UE
€ 202 800
Adres
Altkircherstrasse 4
4054 Basel
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Christoph Helma (Dr.)
EDELWEISS CONNECT GMBH
Szwajcaria
Wkład UE
€ 296 300
Adres
Hochbergerstrasse 60C
4057 Basel
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Barry Hardy (Dr.)
Department of Health
United Kingdom
Wkład UE
€ 149 660
Adres
Quarry House, Quarry Hill
LS2 7UE Leeds
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Amanda King (Ms.)