Objetivo In this project, we propose to explore a new area in biological research aiming at dissecting emerging of properties of the innate immune responses. Our system model is the Natural Killer (NK) cell. Specifically, we will investigate the mechanisms by which these players of innate immunity achieve tolerance to self and participate to immune responses. Multidisciplinary approaches will be combined to achieve groundbreaking results at nanoscopic and macroscopic scales on the following issues:- How NK cells are educated to self-tolerance?- How NK cells distinguish their targets from normal cells?- How NK cells participate to immunological memory?THINK (THe Immune function of Natural Killer cells) is a challenging project supported by an array of preliminary data obtained by our team of investigators in various fields of expertise:- innate immunity and NK cells in human and mouse models- random insertional mutagenesis in the mouse- genome-wide epigenetic, transcriptomic and RNAi analysis and- state-of-the-art optical imaging techniques from intravital biphoton microscopy to the quantification of proteins in nano-sized areas of the cell.THINK is thus a multidisciplinary project that bridges disciplines: immunology, biophysics, genetics and epigenetics. In a scientific perspective, we think that this project will open new technological and scholar horizons, in reassessing the actual concepts on the links between innate immunity, tissue homeostasis and stress response. In a clinical and translational perspective, we also think that this project will help to design innovative NK cell-based therapies and immunomonitoring protocols. Ámbito científico medical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesbiophysicsmedical and health sciencesbasic medicinephysiologyhomeostasisnatural sciencesbiological sciencesgeneticsepigeneticsnatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection Convocatoria de propuestas ERC-2010-AdG_20100317 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida UNIVERSITE D'AIX MARSEILLE Aportación de la UE € 2 500 000,00 Dirección BOULEVARD CHARLES LIVON 58 LE PHARO 13284 Marseille Francia Ver en el mapa Región Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Tipo de actividad Higher or Secondary Education Establishments Investigador principal Eric Vivier (Prof.) Contacto administrativo Céline Damon (Ms.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITE D'AIX MARSEILLE Francia Aportación de la UE € 2 500 000,00 Dirección BOULEVARD CHARLES LIVON 58 LE PHARO 13284 Marseille Ver en el mapa Región Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Tipo de actividad Higher or Secondary Education Establishments Investigador principal Eric Vivier (Prof.) Contacto administrativo Céline Damon (Ms.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos
