Project description
Ultrasmall and multi-talented: Nanohybrid materials for diagnosis and therapy
Nanoscale materials have gained a place in the spotlight as enablers of combination diagnostic-therapeutic technologies due to their tiny penetrating sizes and their unique functional properties. Nanohybrids that contain both organic and inorganic components, including metallic ones, offer tremendous opportunity for the functionalisation of biological or bioactive molecules. The EU-funded UNAT project will explore the capabilities of metal-carbon nanohybrids for multimodal in vivo imaging and therapy of tumours via electromagnetic radiation. The diagnosis and therapy of cancer will be evaluated through an ambitious campaign of preclinical in vitro and in vivo experiments.
Objective
Nowadays, research focusing on control and use of nanomaterials in different areas including life sciences has become a key driver of innovation. UNAT project aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for advanced theranostic application. Indeed, development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic medicines. UNAT will develop innovative approaches for synthesis and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy of cancer. In particular, carbon cores of NHs will be chemically synthesized from biomasses and bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow to evaluate theranostic potential of the NHs.
UNAT will associate an industrial partner from Greece (Bioemtech), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR). The uptake efficiency and specific localization of the NHs in biological cells depending on their intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the NHs will allow their application as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. The multimodal imaging strategy will allow us to correlate the images obtained with the use of various imaging facilities to increase general reliability of visualization of the NHs localization in tumours. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. Strongly complementary research experiences of the partners involved in UNAT and a high degree of cooperative integration between them will allow a deep scientific study of the theranostic potential of the NHs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
- agricultural sciences agricultural biotechnology biomass
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-RISE-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69622 Villeurbanne Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.