Project description
High-chemical-resolution microscopy based on short-pulse terahertz sources
The EU-funded MIMOSA project aims to provide an alternative to nanoscale tomography with a high chemical resolution for biological and medical applications, based on the tomographic atom probe (TAP). The project aims to develop a prototype of a new TAP triggered by intense stable terahertz (THz) pulses at high repetition rates. Another project goal is to deliver a prototype of an efficient intense THz source based on novel ultrafast high-energy fibre lasers that can be used in nanotomography for biological and medical applications and as a test platform for commercialisation of the THz-triggered TAP.
Objective
Cryo-electron microscopy and tomography have been among the greatest achievements in biological imaging, but these techniques suffer from insufficient chemical resolution.
The ultimate goal of MIMOSA is to provide an alternative to tomography at the nanoscale with a high chemical resolution for biological and medical systems, based on Tomographic Atom Probe (TAP).
MIMOSA aims to prototype a new TAP triggered by intense terahertz (THz) pulses that are stable at high repetition rates and exhibit versatile and tailored properties.
MIMOSA relies on the integration of trans-disciplinary fields in bio-imaging, optics, ultrafast lasers and intense THz sources, big-data treatment and physics of the interaction between THz waves and matter.
MIMOSA aims to prototype in parallel an efficient intense THz source based on a new technology with ultrafast high-energy fiber lasers. This source can be used in nano-tomography for biological and medical applications but also as a test platform for a foreseeable commercialization of the THz-triggered TAP.
The MIMOSA team members are leaders in TAP development, 3D medical and bio-imaging, ultrafast lasers development with advanced techniques for shaping and control of the optical beam’s properties and theoretical physics. With MIMOSA we are uniquely positioned to succeed and to raise the competitiveness of Europe in microscopy development on the international scene.
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Funding Scheme
HORIZON-EIC - HORIZON EIC GrantsCoordinator
75794 Paris
France