Project description
Bioresorbable implant for in situ chemotherapeutics monitoring
Health condition monitoring involves the analysis of biological fluids including blood, serum, plasma and urine. However, under specific medical situations such as acute trauma or cancer treatment, there is a need to continuously record specific analytes as well as drug levels in vivo. To address this demand, the RESORB project funded by the European Innovation Council will develop a novel chemical sensing technology that employs bioresorbable materials. The system will be implanted in the body to monitor in real time various analytes as well as the levels of chemotherapeutic drugs in situ for approximately 2 months. The biodegradable nature of the implant avoids complications associated with its surgical removal and facilitates fine-tuning of drug dose administration for optimal clinical outcome.
Objective
We envision a radically new technology for in-vivo bioresorbable chemical sensing, where optical devices, power and light sources, synthetic receptors - made out of materials that completely dissolve with biologically benign byproducts in biofluids - will be developed and integrated together. The sensing system, the size of 1 EuroCent, will be coated by a long-lived biocompatible polymer designed with on-demand degradation, then implanted in the body to monitor in-vivo, in-situ, and in real-time a chemotherapeutic drug, doxorubicin, commonly used to treat cancer; the system is then fully and safely RESORBed once no more needed using an external temperature-trigger that initiates the dissolution of the protecting coating and, in turn, of the system, avoiding device-retrieval surgery that may cause tissue lesion/infection. The general objective is to demonstrate fabrication, operation (2 months) in-vivo and in real-time - then dissolution - of such a bioresorbable chemical sensing system for the detection of doxorubicin in an animal model. This will break a new ground in in-situ monitoring of chemotherapeutic drug enabling – for the first time – a fine tuning of the drug dose at the tumor site, increasing patient survival rate. Being aware of the project risks, we have broken down the general into different specific objectives, identified a set of Key Performance Indicators, alternative material synthesis/device fabrication techniques, mitigation measures to tackle major risks. The RESORB technology truly represents the foundation of a future technology for personalized medicine, enabling to address a number of medical issues for which continuous and localized monitoring of specific analytes (i.e. biomarkers and drugs) in-vivo for a prescribed time is of chief importance, e.g. acute trauma treatment, post-surgery sepsis, drug therapeutic profiling, and other, all examples for which ex-situ analysis of biofluids has proved to be not fully adequate for clinical needs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- natural sciences chemical sciences polymer sciences
- engineering and technology materials engineering coating and films
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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HORIZON.3.1.1 - The Pathfinder for Advanced Research
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2021-PATHFINDEROPEN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
56126 Pisa
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.