Objective
Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.
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Coordinator
75794 Paris
France
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Participants (10)
80539 Munchen
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2333 ZA Leiden
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4058 Basel
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L69 7ZX Liverpool
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48160 DERIO VIZCAYA
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Participation ended
SN2 1FL Swindon
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60323 Frankfurt Am Main
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55128 Mainz
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DD1 4HN Dundee
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2880 Bagsvaerd
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Partners (9)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Leioa
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Lisboa
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75014 Paris
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Basel
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1066CX Amsterdam
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1017BT Amsterdam
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Cambridge
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
64293 Darmstadt
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