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Safety BY Design Of nanoMaterials - From Lab Manufacture to Governance and Communication: Progressing Up the TRL Ladder

Project description

DEENESFRITPL

'Safety-by-design' – Towards safer nanotechnology applications

High-performance engineered nanomaterials hold great promise for a variety of fields including medicine, electronics and energy. To achieve scalable quantities of nanomaterials that are safe to use, new methodologies for nanomaterial synthesis need to be explored, which will investigate the impact of nanomaterials on humans and the environment at the start of the process. One of the main goals of the EU-funded SABYDOMA project is to build high-throughput online platforms where nanomaterials are manufactured and screened at the point of production. Another goal is to extend the impact of safe-by-design nanomaterials to real-world situations. The project will examine four industrial case studies set up by four industrial partners to advance the technology readiness level from 4 to 6.

Objective

The SABYDOMA programme addresses developments in the safety by design (SbD) paradigm by examining four industrial case studies in detail where the TRLs will advance from 4 to 6. Each TRL activity will progress from being lab based at TRL4 to being industry based at TRL6. The TRL4 activity will involve only innovation with regular industrial communication whereas the TRL6 activity will involve industrially located activities with innovation communication. One of the novel themes of this study is to use system control and optimisation theory including the Model Predictive Control (MPC) philosophy to bind the whole subject of SbD from laboratory innovation to the industrial production line and from decision making processes to project governance. An equally important innovative step is the building of high throughput online platforms where nanomaterial (NM) is manufactured and screened at the point of production. The screening signal controls the NM redesign and production in a feedback loop. Screens will involve (a) physiochemical sensing elements (b) in-vitro targets of increasing complexity from the 2D biomembrane to cell-line and more complex cell-line elements; and, (c) multiple in-vitro targets with multiple end-points; developed in current H2020 projects. Two of the industrial studies include composite coating manufacture where the coating’s stability and toxicity will be tested using a flow through microfluidic flow cell system coupled to online screens. This is part of the release and ageing investigations on the NM and NM coatings and the results of these will feed back to the production line design. At every step on the TRL ladder the in-silico modelling will be applied to optimise and redefine the relevant activities. By the same token regulatory and governance principles of SbD will be used to refine the technological development. The final deliverable will be four distinct technologies applying SbD to the four industrial processes respectively.

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Programme(s)

Topic(s)

Call for proposal

H2020-NMBP-TO-IND-2018-2020

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Sub call

H2020-NMBP-TO-IND-2019

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY OF LEEDS
Net EU contribution
€ 1 163 977,50
Address
WOODHOUSE LANE
LS2 9JT Leeds
United Kingdom

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 1 163 977,50

Participants (20)

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Last update: 18 December 2023

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Permalink: https://cordis.europa.eu/project/id/862296

European Union, 2024