Nematode-free livestock Nematode infections cost the European sheep industry alone over EUR 100 million annually. A systems biology approach can encourage the livestock sector to harness genetic know-how to control nematodes. Health © Thinkstock The mainstay for the farmer to control nematode worms is anthelmintics – medication that physically expels the parasitic worms. However, nematodes are forging ahead in the genetic race and developing resistance to such therapies.Applying a holistic approach, the 'A systems biology approach to controlling nematode infections of livestock' (NEMATODESYSTEMHEALTH) project is looking at the relationship between the host and the parasite. All-encompassing, this angle includes all levels from population to molecules. There are two barriers to the widespread exploitation of genetic resistance by the farmer. Many lack the necessary expertise in quantitative genetics and are also unaware of the potentially harmful side-effects of genetic resistance.Information from the interplay between the host and parasite will be applied in breeding schemes, particularly markers, genes and selection indices. The team are integrating the data they collect using sophisticated statistical analyses and mathematical modelling. The data will then be applied on farms in Europe as nematode control schemes.Sustainable research means training and the NEMATODESYSTEMHEALTH programme will be supplying young researchers with the necessary skills to understand and control nematode infections. It is anticipated that the post doc trainees will submit their theses by the end of the project in 2014.Selective breeding for nematode resistance has been successful in Australia and New Zealand. Application of this ground-breaking research in Europe will create a more sustainable and profitable future for the livestock industry. Keywords Nematode, infection, livestock, systems approach, drug resistance, host-parasite relationship, breeding programme
