Projektbeschreibung
Micro/nano based sub-systems
Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) are major causes of unexpected mortality in hospitals throughout Europe. D-dimer is a recognised biomarker for the diagnosis of a thrombus and is routinely examined in hospital laboratories using a traditional ELISA technique. The clinical need for a fast predictive test for D-dimer has prompted the development of test kits, some of which are deployed at the point-of-care as a means of guiding clinicians.Current D-dimer point-of-care diagnostic kits do not provide accurate, quantitative analysis ? creating uncertainty amongst clinicians who are unable to exclude DVT/PE as a result, and consequently unnecessarily refer many patients for high-cost Doppler ultrasound imaging, creating pressure on healthcare services across Europe.The consortium, industrially driven by a leading healthcare supplies provider, incorporating skilled SMEs in electro-analysis instrumentation and bio-engineering and including academic bases in clinical pharmacology, microelectronics, analytical electrochemistry and micro-fabrication ? aims to integrate four key technologies areas:Bio-engineered antibodies for high specificity immunoassay diagnosticsNano/micro engineered impedimetric analysis electrodes incorporating bio-compatible conducting polymer substrates for enhanced detection capabilitiesDevelopment and packaging of a disposable, sterile, microfluidic manifold enabling diagnostics at the point-of-careDeveloping e-Health diagnostic software toolkit for high positive and negative predictivity D-dimer testsDVT-IMP will innovation bio-nano/micro-informatic technologies that will enable the development of a point-of-care device with advanced diagnostic capabilities, including the output of quantitative D-dimer levels, thus increasing confidence and certainty for clinicians, enabling them to confirm or exclude the risk of DVT/PE using the high negative and positive predictive capabilities of the DVT-IMP prototype
Wissenschaftliches Gebiet
- medical and health scienceshealth scienceshealth care serviceseHealth
- natural scienceschemical scienceselectrochemistry
- medical and health sciencesclinical medicineangiologyvascular diseases
- natural sciencesphysical scienceselectromagnetism and electronicsmicroelectronics
- medical and health sciencesbasic medicinepharmacology and pharmacy
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
FP6-2005-IST-5
Andere Projekte für diesen Aufruf anzeigen
Finanzierungsplan
STREP - Specific Targeted Research ProjectKoordinator
TS1 3BA Middlesbrough
Vereinigtes Königreich