Project description DEENESFRITPL Biobased compounds engineered from marine and extremophilic microorganisms The EU-funded SECRETed project will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds produced by marine and extremophilic microorganisms. Researchers will screen microbial collections from earlier European initiatives and apply machine-learning algorithms to identify the genetic mechanisms responsible for their biosynthesis. Biosynthetic gene clusters in charge of the production of these molecules will be reverse engineered to expand the chemical diversity and improve the industrial sustainable exploitation of such biobased compounds. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes. Show the project objective Hide the project objective Objective SECRETed is an EU-H2020 multidisciplinary project involving multiple stakeholders and with a strong participation of SMEs to fully exploit the potential of aquatic biotechnology and produce novel industrial products for the agrochemical, pharmaceutical, cosmetic and chemistry sectors. SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. The project will focus on reutilizing previous sampling efforts by screening already collected microbial collections from previous European initiatives. Machine Learning algorithms (ML) will be deployed to reveal the genetic mechanisms responsible for their biosynthesis and to expand the chemical diversity of such bio-based compounds. To this end, databases inspection and new collected data will be employed to construct a unique microbial amphiphilic compound chemical space comprehending molecular structures, physicochemical characteristics, associated bioactivities and revealed genetic mechanisms responsible for their biosynthesis. To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. Their potential benefits will be broadened by looking for Industry-driven (agrochemical, cosmetic, nutrition and health) formulations based on the engineered combinations of the genetic elements expressed in suitable microbial hosts. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes. Fields of science natural sciencesbiological sciencesmarine biologynatural sciencesbiological sciencesmolecular biologymolecular geneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencescomputer and information sciencesartificial intelligencemachine learning Keywords Biosurfactants Marine Siderophores Amphipathic molecules 'Mix and Match' 'Design-Build-Test' Programme(s) H2020-EU.3.2. - SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy Main Programme H2020-EU.3.2.4.1. - Fostering the bio-economy for bio-based industries Topic(s) FNR-11-2020 - Prospecting aquatic and terrestrial natural biological resources for biologically active compounds Call for proposal H2020-FNR-2020 See other projects for this call Sub call H2020-FNR-2020-2 Funding Scheme RIA - Research and Innovation action Coordinator IDENER RESEARCH & DEVELOPMENT AGRUPACION DE INTERES ECONOMICO Net EU contribution € 933 750,00 Address Calle early ovington 24-8 41300 La rinconada sevilla Spain See on map Region Sur Andalucía Sevilla Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (14) Sort alphabetically Sort by Net EU contribution Expand all Collapse all PHARMA MAR SA Spain Net EU contribution € 334 730,00 Address Avda de los reyes 1 poligono industrial la mina colmenar viejo 28770 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACCUPLEX DIAGNOSTICS LTD Ireland Net EU contribution € 321 875,00 Address 114 the old mill Ratoath See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ireland Eastern and Midland Mid-East Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MATIS OHF Iceland Net EU contribution € 605 062,50 Address Vinlandsleid 12 113 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STAZIONE ZOOLOGICA ANTON DOHRN Italy Net EU contribution € 408 375,00 Address Villa comunale 80121 Napoli See on map Region Sud Campania Napoli Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece Net EU contribution € 546 500,00 Address 6 christou lada str 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany Net EU contribution € 498 250,00 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BLUE SYNERGY SL Spain Net EU contribution € 313 500,00 Address Calle maudes 51 planta 8 puerta 1 28003 Madrid See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BIO BASE EUROPE PILOT PLANT VZW Belgium Net EU contribution € 758 125,00 Address Rodenhuizekaai 1 9042 Desteldonk gent See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SPHERA ENCAPSULATION SRL Italy Net EU contribution € 480 453,75 Address Via alessandro volta 15a 37069 Villafranca di verona dossobuono See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Veneto Verona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom Net EU contribution € 472 320,00 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD DE SEVILLA Spain Net EU contribution € 617 515,00 Address Calle s. fernando 4 41004 Sevilla See on map Region Sur Andalucía Sevilla Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LUNDS UNIVERSITET Sweden Net EU contribution € 541 250,00 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EXELISIS IKE Greece Net EU contribution € 377 000,00 Address Skra 12 & dekeleias 215 143 42 Nea filadelfeia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Αττική Aττική Κεντρικός Τομέας Αθηνών Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SYLENTIS SAU Spain Net EU contribution € 579 111,50 Address Plaza descubridor diego de ordas 3 28003 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 1,00