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Sustainable Exploitation of bio-based Compounds Revealed and Engineered from naTural sources.

Objective

SECRETed is an EU-H2020 multidisciplinary project involving multiple stakeholders and with a strong participation of SMEs to fully exploit the potential of aquatic biotechnology and produce novel industrial products for the agrochemical, pharmaceutical, cosmetic and chemistry sectors. SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. The project will focus on reutilizing previous sampling efforts by screening already collected microbial collections from previous European initiatives. Machine Learning algorithms (ML) will be deployed to reveal the genetic mechanisms responsible for their biosynthesis and to expand the chemical diversity of such bio-based compounds. To this end, databases inspection and new collected data will be employed to construct a unique microbial amphiphilic compound chemical space comprehending molecular structures, physicochemical characteristics, associated bioactivities and revealed genetic mechanisms responsible for their biosynthesis. To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. Their potential benefits will be broadened by looking for Industry-driven (agrochemical, cosmetic, nutrition and health) formulations based on the engineered combinations of the genetic elements expressed in suitable microbial hosts. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes.

Call for proposal

H2020-FNR-2020-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

IDENER RESEARCH & DEVELOPMENT AGRUPACION DE INTERES ECONOMICO
Address
Calle Early Ovington 24-8
41300 La Rinconada Sevilla
Spain
Activity type
Research Organisations
EU contribution
€ 933 750

Participants (14)

PHARMAMAR, S.A.
Spain
EU contribution
€ 334 730
Address
Avda. De Los Reyes , Poligono Industrial La Mina 1
28770 Colmenar Viejo (Madrid)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACCUPLEX DIAGNOSTICS LTD
Ireland
EU contribution
€ 321 875
Address
114 The Old Mill
Ratoath
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MATIS OHF
Iceland
EU contribution
€ 605 062,50
Address
Vinlandsleid 12
113 Reykjavik
Activity type
Research Organisations
STAZIONE ZOOLOGICA ANTON DOHRN
Italy
EU contribution
€ 408 375
Address
Villa Comunale
80121 Napoli
Activity type
Research Organisations
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 546 500
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 498 250
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
BLUE SYNERGY SL
Spain
EU contribution
€ 313 500
Address
Calle Doctor Castelo, 44, Bajo Izquierda
28009 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIO BASE EUROPE PILOT PLANT VZW
Belgium
EU contribution
€ 758 125
Address
Rodenhuizekaai 1
9042 Desteldonk Gent
Activity type
Other
SPHERA ENCAPSULATION SRL
Italy
EU contribution
€ 480 453,75
Address
Strada Le Grazie 15
37134 Verona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 472 320
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE SEVILLA
Spain
EU contribution
€ 617 515
Address
Calle S. Fernando 4
41004 Sevilla
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 541 250
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
EXELISIS IKE
Greece
EU contribution
€ 377 000
Address
Xanthis 19
111 47 Galatsi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SYLENTIS SAU
Spain
EU contribution
€ 579 111,50
Address
Plaza Descubridor Diego De Ordas 3
28003 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)