Descripción del proyecto
Compuestos de base biológica elaborados a partir de microorganismos marinos y extremófilos
El proyecto SECRETed, financiado con fondos europeos, desarrollará nuevas moléculas híbridas con propiedades a medida obtenidas a partir de la combinación de genes biosintéticos de compuestos anfifílicos producidos por microorganismos marinos y extremófilos. Los investigadores examinarán colecciones microbianas procedentes de iniciativas europeas anteriores y aplicarán algoritmos de aprendizaje automático para identificar los mecanismos genéticos responsables de su biosíntesis. Los grupos de genes biosintéticos encargados de la producción de estas moléculas se someterán a ingeniería inversa para ampliar la diversidad química y mejorar la explotación industrial sostenible de tales compuestos de base biológica. A continuación, se diseñarán, construirán y probarán nuevas cepas en un proceso iterativo para desarrollar procesos industriales viables y sostenibles.
Objetivo
SECRETed is an EU-H2020 multidisciplinary project involving multiple stakeholders and with a strong participation of SMEs to fully exploit the potential of aquatic biotechnology and produce novel industrial products for the agrochemical, pharmaceutical, cosmetic and chemistry sectors. SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. The project will focus on reutilizing previous sampling efforts by screening already collected microbial collections from previous European initiatives. Machine Learning algorithms (ML) will be deployed to reveal the genetic mechanisms responsible for their biosynthesis and to expand the chemical diversity of such bio-based compounds. To this end, databases inspection and new collected data will be employed to construct a unique microbial amphiphilic compound chemical space comprehending molecular structures, physicochemical characteristics, associated bioactivities and revealed genetic mechanisms responsible for their biosynthesis. To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. Their potential benefits will be broadened by looking for Industry-driven (agrochemical, cosmetic, nutrition and health) formulations based on the engineered combinations of the genetic elements expressed in suitable microbial hosts. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FNR-2020-2
Régimen de financiación
RIA - Research and Innovation actionCoordinador
41300 LA RINCONADA SEVILLA
España