Improving Prognosis by using innovative methods to diAgnose Causes of Encephalitis

Project Information

I-PACE

Grant agreement ID: 101001237

DOI

10.3030/101001237

EC signature date 14 June 2021

Start date 1 December 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 968 996,00

EU contribution

€ 1 968 996,00

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Drafting of a data management planto be submitted by month 6 of the project

Publications

Peer reviewed articles (22)

Heparin‐Binding Protein in Cerebrospinal Fluid as a Biomarker for Bacterial Meningitis: A Study of Diagnostic Accuracy

Author(s): Sabine E. Olie, Steven L. Staal, Ana C. da Cruz Campos, Jacob Bodilsen, Henrik Nielsen, Diederik van de Beek, Matthijs C. Brouwer
Published in: Annals of Neurology, 2025, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.27193

Diagnostic accuracy of clinical and laboratory characteristics in suspected non-surgical nosocomial central nervous system infections.

Author(s): van Zeggeren IE, Pennartz CJ, Ter Horst L, van de Beek D, Brouwer MC; I-PACE Study Group.
Published in: Journal of Hospital Infections, Issue 145, 2024, Page(s) 99-105, ISSN 0195-6701
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jhin.2023.12.015

Neurological infections in 2023: surveillance and prevention

Author(s): Diederik van de Beek, Matthijs C Brouwer
Published in: Lancet Neurology, Issue 23, 2024, Page(s) 30-32, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(23)00445-3

Intracerebral haemorrhage in bacterial meningitis

Author(s): Shahrzad S. Deliran, Matthijs C. Brouwer, Diederik van de Beek
Published in: Journal of infection, Issue 18-06-2022, 2022, Page(s) S0163-4453(22)00368-1, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.06.013

Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections

Author(s): Sabine E. Olie; Steven L. Staal; Liora ter Horst; Ingeborg E. van Zeggeren; Wing K. Man; Michael W.T. Tanck; Diederik van de Beek; Matthijs C. Brouwer
Published in: Journal of Infection, Issue 2, 2024, Page(s) 106117, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.01.016

Confused about confusion

Author(s): Anne M. Spanjaart, Fleur M. van der Valk, Geeske van Rooijen, Matthijs C. Brouwer, Marie J. Kersten
Published in: New England Journal of Medicine, Issue 386, 2022, Page(s) 80-87, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmcps2114818.

Increasing incidence of community-acquired adult group A streptococcal meningitis in the Netherlands

Author(s): Evelien H G M Drost, Nora Chekrouni, Thijs M van Soest, Kim Schipper, Nina M van Sorge, Matthijs C Brouwer, Diederik van de Beek
Published in: Journal of Infection, Issue 88(1), 2024, Page(s) 68-70, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2023.11.007

Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach

Author(s): Kinsella, Cormac M; Edridge, Arthur W D; van Zeggeren, Ingeborg E; Deijs, Martin; van de Beek, Diederik; Brouwer, Matthijs C; van der Hoek, Lia
Published in: Fluids and barriers of the CNS, 19(1):102. BioMed Central, Issue 3, 2022, Page(s) 102, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-022-00400-5

Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy

Author(s): Steven L. Staal, Sabine E. Olie, Liora ter Horst, Ingeborg E. van Zeggeren, Diederik van de Beek, Matthijs C. Brouwer & I.-PACE Study Group
Published in: Infection, 2024, Page(s) online ahead of print, ISSN 0300-8126
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02200-5

Seizures in adults with suspected central nervous system infection

Author(s): Olie, Sabine E.; van Zeggeren, Ingeborg E.; ter Horst, Liora; Citroen, J.; van Geel, B. M.; Heckenberg, S. G.B.; Jellema, K.; Kester, M. I.; Killestein, J.; Mook, B. B.; Titulaer, M. J.; van Veen, K. E.B.; Verschuur, C. V.M.; van de Beek, Diederik; Brouwer, Matthijs C.
Published in: BMC neurology, Issue 2, 2022, Page(s) 426, ISSN 1471-2377
Publisher: BioMed Central
DOI: 10.1186/s12883-022-02927-4

Validation of the encephalitis criteria in adults with a suspected central nervous system infection: An updated score

Author(s): Steven L. Staal, Sabine E. Olie, Diederik van de Beek, Matthijs C. Brouwer
Published in: Journal of Infection, Issue 89, 2024, Page(s) 106239, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106239

Neurofilament light chain in central nervous system infections: a prospective study of diagnostic accuracy

Author(s): Ingeborg E van Zeggeren, Liora Ter Horst, Hans Heijst, Charlotte E Teunissen, Diederik van de Beek, Matthijs C Brouwer
Published in: Scientific reports, Issue 12, 2022, Page(s) 14140, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-17643-9

Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy.

Author(s): Nina S. Groeneveld; Sabine E. Olie; Douwe H. Visser; Linde Snoek; Diederik van de Beek; Matthijs C. Brouwer; Merijn W. Bijlsma
Published in: International journal of infectious diseases, Issue 142, 2024, Page(s) 106970, ISSN 1201-9712
Publisher: Elsevier BV
DOI: 10.1016/j.ijid.2024.02.013

Biomarkers in paediatric bacterial meningitis: a systematic review and meta-analysis of diagnostic test accuracy

Author(s): Nina S. Groeneveld, Merijn W. Bijlsma, Diederik van de Beek, Matthijs C. Brouwer
Published in: Clinical Microbiology and Infection, 2025, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.12.009

Predictors of unfavourable outcome in adults with suspected central nervous system infections: a prospective cohort study

Author(s): Liora Ter Horst, Ingeborg E van Zeggeren, Sabine E Olie; I-PACE Study Group; Diederik van de Beek, Matthijs C Brouwer
Published in: Scientific reports, Issue 13, 2023, Page(s) 21250, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-48472-z

Diagnosing infectious encephalitis: a narrative review

Author(s): Sabine E. Olie, Steven L. Staal, Diederik van de Beek, Matthijs C. Brouwer
Published in: Clinical Microbiology and Infection, Issue 31, 2025, Page(s) 522-528, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.11.026

Adjunctive dexamethasone treatment in adults with listeria monocytogenes meningitis: a prospective nationwide cohort study

Author(s): Matthijs C. Brouwer, Diederik van de Beek
Published in: eClinicalMedicine, Issue 58, 2024, Page(s) 101922, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2023.101922

Sex and Gender Differences in Bacterial Infections

Author(s): Sara P. Dias; Matthijs C. Brouwer; Diederik van de Beek
Published in: Infect Immun, Issue 1, 2022, Page(s) e0028322, ISSN 0019-9567
Publisher: American Society for Microbiology
DOI: 10.1128/iai.00283-22

Diagnostic prediction models for bacterial meningitis in children with a suspected central nervous system infection: a systematic review and prospective validation study

Author(s): Nina S Groeneveld, Merijn W Bijlsma, Ingeborg E van Zeggeren, Steven L Staal, Michael W T Tanck, Diederik van de Beek, Matthijs C Brouwer
Published in: BMJ Open, Issue 14, 2025, Page(s) e081172, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-081172

Bacterial meningitis presenting with a normal cerebrospinal fluid leukocyte count

Author(s): Thijs M. van Soest, NoraChekrouni, Nina M.van Sorge, Matthijs C.Brouwer, Diederik van de Beek
Published in: Journal of Infection, Issue Volume 84, Issue 5, May 2022, 2022, Page(s) 615-620, ISSN 0163-4453
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.02.029

Otitis in Patients With Community-Acquired Bacterial Meningitis: A Nationwide Prospective Cohort Study

Author(s): Martina Ranzenigo, Thijs M van Soest, Erik F Hensen, Paola Cinque, Antonella Castagna, Matthijs C Brouwer, Diederik van de Beek
Published in: Clinical Infectious Diseases, Issue 79, 2024, Page(s) 329-335, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciae221

A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study

Author(s): Thijs M van Soest, Liora Ter Horst, Nora Chekrouni, Merijn W Bijlsma, Matthijs C Brouwer, Daniela Urueta Portillo, Diederik van de Beek, Rodrigo Hasbun
Published in: Clinical microbiology and infection, Issue 29, 2023, Page(s) 360-365, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.10.001