Improving Prognosis by using innovative methods to diAgnose Causes of Encephalitis

Información del proyecto

I-PACE

Identificador del acuerdo de subvención: 101001237

DOI

10.3030/101001237

Fecha de la firma de la CE 14 Junio 2021

Fecha de inicio 1 Diciembre 2021

Fecha de finalización 30 Noviembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 968 996,00

Aportación de la UE

€ 1 968 996,00

Coordinado por

STICHTING AMSTERDAM UMC
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Drafting of a data management planto be submitted by month 6 of the project

Publicaciones

Peer reviewed articles (38)

Validation and clinical implementation of cerebrospinal fluid C-reactive protein for the diagnosis of bacterial meningitis: a prospective diagnostic accuracy study

Autores: Sabine E. Olie, Steven L. Staal, Nina S. Groeneveld, Hans H.M. Schotman, Jacob Bodilsen, Henrik Nielsen, Merijn W. Bijlsma, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: The Lancet Regional Health - Europe, Edición 53, 2025, Página(s) 101309, ISSN 2666-7762
Editor: Elsevier BV
DOI: 10.1016/j.lanepe.2025.101309

Heparin‐Binding Protein in Cerebrospinal Fluid as a Biomarker for Bacterial Meningitis: A Study of Diagnostic Accuracy

Autores: Sabine E. Olie, Steven L. Staal, Ana C. da Cruz Campos, Jacob Bodilsen, Henrik Nielsen, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Annals of Neurology, 2025, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.27193

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Autores: Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, null null, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Annals of Neurology, Edición 98, 2025, Página(s) 851-863, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.27291

Anti-cytokine autoantibodies linked to susceptibility, bacterial load, and outcome in pneumococcal meningitis: prospective cohort studies in CNS infections, Alzheimer's disease, and Parkinson's disease

Autores: Rutger Koning, Nora Chekrouni, Lindsey B. Rosen, Marian A. van Roon, Anke A.G. Tolido, Evelien H.G.M. Drost, Dixie Bakker, Steven L. Staal, Sabine E. Olie, Wing Kit Man, Wilma D.J. van de Berg, Yolande A.L. Pijnenburg, Steven M. Holland, Matthijs C. Brouwer, Diederik van de Beek
Publicado en: eBioMedicine, Edición 121, 2026, Página(s) 105975, ISSN 2352-3964
Editor: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105975

Diagnostic accuracy of clinical and laboratory characteristics in suspected non-surgical nosocomial central nervous system infections.

Autores: van Zeggeren IE, Pennartz CJ, Ter Horst L, van de Beek D, Brouwer MC; I-PACE Study Group.
Publicado en: Journal of Hospital Infections, Edición 145, 2024, Página(s) 99-105, ISSN 0195-6701
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jhin.2023.12.015

Intracranial pressure management in pneumococcal meningitis: first, do no harm

Autores: Matthijs C. Brouwer, Diederik van de Beek
Publicado en: Clinical Microbiology and Infection, Edición 31, 2026, Página(s) 885-887, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2025.03.016

Neurological infections in 2023: surveillance and prevention

Autores: Diederik van de Beek, Matthijs C Brouwer
Publicado en: Lancet Neurology, Edición 23, 2024, Página(s) 30-32, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(23)00445-3

VIDISCA-NGS in cerebrospinal fluid of adults with a suspected viral meningoencephalitis

Autores: Steven L. Staal, Sabine E. Olie, Martin Deijs, Arthur W.D. Edridge, Lia van der Hoek, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Journal of Infection, Edición 91, 2026, Página(s) 106534, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2025.106534

Rabies in humans: A treatment approach

Autores: Cornelis A. De Pijper, Pieter P.A.M. van Thiel, Diederik van de Beek, Matthijs C. Brouwer, Eleonora Aronica, Nicole P. Juffermans, Ron A.A. Mathôt, Corine H. GeurtsvanKessel, Janke Schinkel, Menno D. de Jong, Martin P. Grobusch, Abraham Goorhuis
Publicado en: Travel Medicine and Infectious Disease, Edición 64, 2025, Página(s) 102813, ISSN 1477-8939
Editor: Elsevier BV
DOI: 10.1016/j.tmaid.2025.102813

Intracerebral haemorrhage in bacterial meningitis

Autores: Shahrzad S. Deliran, Matthijs C. Brouwer, Diederik van de Beek
Publicado en: Journal of infection, Edición 18-06-2022, 2022, Página(s) S0163-4453(22)00368-1, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.06.013

Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections

Autores: Sabine E. Olie; Steven L. Staal; Liora ter Horst; Ingeborg E. van Zeggeren; Wing K. Man; Michael W.T. Tanck; Diederik van de Beek; Matthijs C. Brouwer
Publicado en: Journal of Infection, Edición 2, 2024, Página(s) 106117, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.01.016

Confused about confusion

Autores: Anne M. Spanjaart, Fleur M. van der Valk, Geeske van Rooijen, Matthijs C. Brouwer, Marie J. Kersten
Publicado en: New England Journal of Medicine, Edición 386, 2022, Página(s) 80-87, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmcps2114818.

Increasing incidence of community-acquired adult group A streptococcal meningitis in the Netherlands

Autores: Evelien H G M Drost, Nora Chekrouni, Thijs M van Soest, Kim Schipper, Nina M van Sorge, Matthijs C Brouwer, Diederik van de Beek
Publicado en: Journal of Infection, Edición 88(1), 2024, Página(s) 68-70, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2023.11.007

Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach

Autores: Kinsella, Cormac M; Edridge, Arthur W D; van Zeggeren, Ingeborg E; Deijs, Martin; van de Beek, Diederik; Brouwer, Matthijs C; van der Hoek, Lia
Publicado en: Fluids and barriers of the CNS, 19(1):102. BioMed Central, Edición 3, 2022, Página(s) 102, ISSN 2045-8118
Editor: BioMed Central
DOI: 10.1186/s12987-022-00400-5

Neuronal Autoantibodies in Adults After Community-Acquired Bacterial Meningitis

Autores: Steven L. Staal, Liora Ter Horst, Juliette Brenner, Diederik van de Beek, Maarten J. Titulaer, Matthijs C. Brouwer
Publicado en: Neurology Neuroimmunology & Neuroinflammation, Edición 12, 2025, ISSN 2332-7812
Editor: Wolters Kluwer
DOI: 10.1212/nxi.0000000000200454

Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy

Autores: Steven L. Staal, Sabine E. Olie, Liora ter Horst, Ingeborg E. van Zeggeren, Diederik van de Beek, Matthijs C. Brouwer & I.-PACE Study Group
Publicado en: Infection, 2024, Página(s) online ahead of print, ISSN 0300-8126
Editor: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02200-5

Seizures in adults with suspected central nervous system infection

Autores: Olie, Sabine E.; van Zeggeren, Ingeborg E.; ter Horst, Liora; Citroen, J.; van Geel, B. M.; Heckenberg, S. G.B.; Jellema, K.; Kester, M. I.; Killestein, J.; Mook, B. B.; Titulaer, M. J.; van Veen, K. E.B.; Verschuur, C. V.M.; van de Beek, Diederik; Brouwer, Matthijs C.
Publicado en: BMC neurology, Edición 2, 2022, Página(s) 426, ISSN 1471-2377
Editor: BioMed Central
DOI: 10.1186/s12883-022-02927-4

Validation of the encephalitis criteria in adults with a suspected central nervous system infection: An updated score

Autores: Steven L. Staal, Sabine E. Olie, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Journal of Infection, Edición 89, 2024, Página(s) 106239, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106239

Global Case Fatality of Bacterial Meningitis During an 80-Year Period

Autores: Cornelis N. van Ettekoven, Fabian D. Liechti, Matthijs C. Brouwer, Merijn W. Bijlsma, Diederik van de Beek
Publicado en: JAMA Network Open, Edición 7, 2024, Página(s) e2424802, ISSN 2574-3805
Editor: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2024.24802

Neurofilament light chain in central nervous system infections: a prospective study of diagnostic accuracy

Autores: Ingeborg E van Zeggeren, Liora Ter Horst, Hans Heijst, Charlotte E Teunissen, Diederik van de Beek, Matthijs C Brouwer
Publicado en: Scientific reports, Edición 12, 2022, Página(s) 14140, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-17643-9

Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy.

Autores: Nina S. Groeneveld; Sabine E. Olie; Douwe H. Visser; Linde Snoek; Diederik van de Beek; Matthijs C. Brouwer; Merijn W. Bijlsma
Publicado en: International journal of infectious diseases, Edición 142, 2024, Página(s) 106970, ISSN 1201-9712
Editor: Elsevier BV
DOI: 10.1016/j.ijid.2024.02.013

Biomarkers in paediatric bacterial meningitis: a systematic review and meta-analysis of diagnostic test accuracy

Autores: Nina S. Groeneveld, Merijn W. Bijlsma, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Clinical Microbiology and Infection, 2025, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.12.009

Utility of SIRS criteria and QSOFA score in identifying patients with central nervous system infections at risk for poor outcome

Autores: Yannick C. Resok, Sabine E. Olie, Korné Jellema, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-21163-7

Predictors of unfavourable outcome in adults with suspected central nervous system infections: a prospective cohort study

Autores: Liora Ter Horst, Ingeborg E van Zeggeren, Sabine E Olie; I-PACE Study Group; Diederik van de Beek, Matthijs C Brouwer
Publicado en: Scientific reports, Edición 13, 2023, Página(s) 21250, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-48472-z

Diagnosing infectious encephalitis: a narrative review

Autores: Sabine E. Olie, Steven L. Staal, Diederik van de Beek, Matthijs C. Brouwer
Publicado en: Clinical Microbiology and Infection, Edición 31, 2025, Página(s) 522-528, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.11.026

Adjunctive dexamethasone treatment in adults with listeria monocytogenes meningitis: a prospective nationwide cohort study

Autores: Matthijs C. Brouwer, Diederik van de Beek
Publicado en: eClinicalMedicine, Edición 58, 2024, Página(s) 101922, ISSN 2589-5370
Editor: Elsevier
DOI: 10.1016/j.eclinm.2023.101922

Sex and Gender Differences in Bacterial Infections

Autores: Sara P. Dias; Matthijs C. Brouwer; Diederik van de Beek
Publicado en: Infect Immun, Edición 1, 2022, Página(s) e0028322, ISSN 0019-9567
Editor: American Society for Microbiology
DOI: 10.1128/iai.00283-22

Low Diagnostic Accuracy of Encephalitis Criteria Hinders Interpretation of the Absence of Cerebrospinal Fluid Pleiocytosis

Autores: Steven L Staal, Sabine E Olie, Diederik van de Beek, Matthijs C Brouwer
Publicado en: Clinical Infectious Diseases, Edición 81, 2025, Página(s) e56-e57, ISSN 1058-4838
Editor: University of Chicago Press
DOI: 10.1093/cid/ciaf096

Diagnostic prediction models for bacterial meningitis in children with a suspected central nervous system infection: a systematic review and prospective validation study

Autores: Nina S Groeneveld, Merijn W Bijlsma, Ingeborg E van Zeggeren, Steven L Staal, Michael W T Tanck, Diederik van de Beek, Matthijs C Brouwer
Publicado en: BMJ Open, Edición 14, 2025, Página(s) e081172, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-081172

Bacterial meningitis presenting with a normal cerebrospinal fluid leukocyte count

Autores: Thijs M. van Soest, NoraChekrouni, Nina M.van Sorge, Matthijs C.Brouwer, Diederik van de Beek
Publicado en: Journal of Infection, Edición Volume 84, Edición 5, May 2022, 2022, Página(s) 615-620, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.02.029

Diagnostic Accuracy of Clinical Signs and Biochemical Parameters for External Ventricular CSF Catheter-Associated Infection

Autores: Kirsten R.I.S. Dorresteijn, Rolf J. Verheul, Gabriëlle A.E. Ponjee, Rishi Nandoe Tewarie, Marcella C.A. Müller, Diederik van de Beek, Matthijs C. Brouwer, Korné Jellema
Publicado en: Neurology Clinical Practice, Edición 12, 2024, Página(s) 298-306, ISSN 2163-0402
Editor: Lippincott Williams and Wilkins
DOI: 10.1212/cpj.0000000000200059

Brain Abscesses Complicating Bacterial Meningitis—A Nationwide Cohort Study From the Netherlands

Autores: Fabian D. Liechti, Evelien H. G. M. Drost, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek
Publicado en: European Journal of Neurology, Edición 33, 2026, ISSN 1351-5101
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ene.70524

Otitis in Patients With Community-Acquired Bacterial Meningitis: A Nationwide Prospective Cohort Study

Autores: Martina Ranzenigo, Thijs M van Soest, Erik F Hensen, Paola Cinque, Antonella Castagna, Matthijs C Brouwer, Diederik van de Beek
Publicado en: Clinical Infectious Diseases, Edición 79, 2024, Página(s) 329-335, ISSN 1058-4838
Editor: University of Chicago Press
DOI: 10.1093/cid/ciae221

Diagnostic Yield of Anti‐Neuronal Antibody Testing in Patients Suspected of an Infectious Encephalitis

Autores: Liora ter Horst, Juliette Brenner, Ingeborg E. van Zeggeren, null null, Diederik van de Beek, Maarten J. Titulaer, Matthijs C. Brouwer
Publicado en: European Journal of Neurology, Edición 32, 2025, ISSN 1351-5101
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ene.70359

Clinical features and outcomes of <i>Staphylococcus aureus</i> brain abscess in Denmark and the Netherlands: a multicentre cohort study

Autores: Emilie Marie Eriksen, Merijn Bijlsma, Sabine Olie, Lykke Larsen, Merete Storgaard, Helene Mens, Henrik Nielsen, Matthijs Brouwer, Jacob Bodilsen, null null
Publicado en: Infectious Diseases, Edición 58, 2026, Página(s) 507-517, ISSN 2374-4235
Editor: Informa UK Limited
DOI: 10.1080/23744235.2025.2607395

Effect of the COVID-19 pandemic on clinical characteristics and outcomes of adult pneumococcal meningitis patients – a Dutch prospective nationwide cohort study

Autores: Fabian D. Liechti, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek
Publicado en: Infection, Edición 52, 2024, Página(s) 1657-1662, ISSN 0300-8126
Editor: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02305-x

A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study

Autores: Thijs M van Soest, Liora Ter Horst, Nora Chekrouni, Merijn W Bijlsma, Matthijs C Brouwer, Daniela Urueta Portillo, Diederik van de Beek, Rodrigo Hasbun
Publicado en: Clinical microbiology and infection, Edición 29, 2023, Página(s) 360-365, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.10.001

Sex differences in bacterial meningitis and associations with socioeconomic indicators: a systematic review and meta-analysis with metaregression

Autores: Fabian D Liechti, Cornelis N van Ettekoven, Matthijs C Brouwer, Merijn Bijlsma, Diederik van de Beek
Publicado en: BMJ Global Health, Edición 10, 2025, Página(s) e016802, ISSN 2059-7908
Editor: BMJ
DOI: 10.1136/bmjgh-2024-016802