Improving Prognosis by using innovative methods to diAgnose Causes of Encephalitis

Informazioni relative al progetto

I-PACE

ID dell’accordo di sovvenzione: 101001237

DOI

10.3030/101001237

Data della firma CE 14 Giugno 2021

Data di avvio 1 Dicembre 2021

Data di completamento 30 Novembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 968 996,00

Contributo UE

€ 1 968 996,00

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Drafting of a data management planto be submitted by month 6 of the project

Pubblicazioni

Peer reviewed articles (22)

Heparin‐Binding Protein in Cerebrospinal Fluid as a Biomarker for Bacterial Meningitis: A Study of Diagnostic Accuracy

Autori: Sabine E. Olie, Steven L. Staal, Ana C. da Cruz Campos, Jacob Bodilsen, Henrik Nielsen, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Annals of Neurology, 2025, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.27193

Diagnostic accuracy of clinical and laboratory characteristics in suspected non-surgical nosocomial central nervous system infections.

Autori: van Zeggeren IE, Pennartz CJ, Ter Horst L, van de Beek D, Brouwer MC; I-PACE Study Group.
Pubblicato in: Journal of Hospital Infections, Numero 145, 2024, Pagina/e 99-105, ISSN 0195-6701
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jhin.2023.12.015

Neurological infections in 2023: surveillance and prevention

Autori: Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Lancet Neurology, Numero 23, 2024, Pagina/e 30-32, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(23)00445-3

Intracerebral haemorrhage in bacterial meningitis

Autori: Shahrzad S. Deliran, Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: Journal of infection, Numero 18-06-2022, 2022, Pagina/e S0163-4453(22)00368-1, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.06.013

Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections

Autori: Sabine E. Olie; Steven L. Staal; Liora ter Horst; Ingeborg E. van Zeggeren; Wing K. Man; Michael W.T. Tanck; Diederik van de Beek; Matthijs C. Brouwer
Pubblicato in: Journal of Infection, Numero 2, 2024, Pagina/e 106117, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.01.016

Confused about confusion

Autori: Anne M. Spanjaart, Fleur M. van der Valk, Geeske van Rooijen, Matthijs C. Brouwer, Marie J. Kersten
Pubblicato in: New England Journal of Medicine, Numero 386, 2022, Pagina/e 80-87, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmcps2114818.

Increasing incidence of community-acquired adult group A streptococcal meningitis in the Netherlands

Autori: Evelien H G M Drost, Nora Chekrouni, Thijs M van Soest, Kim Schipper, Nina M van Sorge, Matthijs C Brouwer, Diederik van de Beek
Pubblicato in: Journal of Infection, Numero 88(1), 2024, Pagina/e 68-70, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2023.11.007

Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach

Autori: Kinsella, Cormac M; Edridge, Arthur W D; van Zeggeren, Ingeborg E; Deijs, Martin; van de Beek, Diederik; Brouwer, Matthijs C; van der Hoek, Lia
Pubblicato in: Fluids and barriers of the CNS, 19(1):102. BioMed Central, Numero 3, 2022, Pagina/e 102, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-022-00400-5

Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy

Autori: Steven L. Staal, Sabine E. Olie, Liora ter Horst, Ingeborg E. van Zeggeren, Diederik van de Beek, Matthijs C. Brouwer & I.-PACE Study Group
Pubblicato in: Infection, 2024, Pagina/e online ahead of print, ISSN 0300-8126
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02200-5

Seizures in adults with suspected central nervous system infection

Autori: Olie, Sabine E.; van Zeggeren, Ingeborg E.; ter Horst, Liora; Citroen, J.; van Geel, B. M.; Heckenberg, S. G.B.; Jellema, K.; Kester, M. I.; Killestein, J.; Mook, B. B.; Titulaer, M. J.; van Veen, K. E.B.; Verschuur, C. V.M.; van de Beek, Diederik; Brouwer, Matthijs C.
Pubblicato in: BMC neurology, Numero 2, 2022, Pagina/e 426, ISSN 1471-2377
Editore: BioMed Central
DOI: 10.1186/s12883-022-02927-4

Validation of the encephalitis criteria in adults with a suspected central nervous system infection: An updated score

Autori: Steven L. Staal, Sabine E. Olie, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Journal of Infection, Numero 89, 2024, Pagina/e 106239, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106239

Neurofilament light chain in central nervous system infections: a prospective study of diagnostic accuracy

Autori: Ingeborg E van Zeggeren, Liora Ter Horst, Hans Heijst, Charlotte E Teunissen, Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Scientific reports, Numero 12, 2022, Pagina/e 14140, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-17643-9

Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy.

Autori: Nina S. Groeneveld; Sabine E. Olie; Douwe H. Visser; Linde Snoek; Diederik van de Beek; Matthijs C. Brouwer; Merijn W. Bijlsma
Pubblicato in: International journal of infectious diseases, Numero 142, 2024, Pagina/e 106970, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/j.ijid.2024.02.013

Biomarkers in paediatric bacterial meningitis: a systematic review and meta-analysis of diagnostic test accuracy

Autori: Nina S. Groeneveld, Merijn W. Bijlsma, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Clinical Microbiology and Infection, 2025, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.12.009

Predictors of unfavourable outcome in adults with suspected central nervous system infections: a prospective cohort study

Autori: Liora Ter Horst, Ingeborg E van Zeggeren, Sabine E Olie; I-PACE Study Group; Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Scientific reports, Numero 13, 2023, Pagina/e 21250, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-48472-z

Diagnosing infectious encephalitis: a narrative review

Autori: Sabine E. Olie, Steven L. Staal, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Clinical Microbiology and Infection, Numero 31, 2025, Pagina/e 522-528, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.11.026

Adjunctive dexamethasone treatment in adults with listeria monocytogenes meningitis: a prospective nationwide cohort study

Autori: Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: eClinicalMedicine, Numero 58, 2024, Pagina/e 101922, ISSN 2589-5370
Editore: Elsevier
DOI: 10.1016/j.eclinm.2023.101922

Sex and Gender Differences in Bacterial Infections

Autori: Sara P. Dias; Matthijs C. Brouwer; Diederik van de Beek
Pubblicato in: Infect Immun, Numero 1, 2022, Pagina/e e0028322, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/iai.00283-22

Diagnostic prediction models for bacterial meningitis in children with a suspected central nervous system infection: a systematic review and prospective validation study

Autori: Nina S Groeneveld, Merijn W Bijlsma, Ingeborg E van Zeggeren, Steven L Staal, Michael W T Tanck, Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: BMJ Open, Numero 14, 2025, Pagina/e e081172, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-081172

Bacterial meningitis presenting with a normal cerebrospinal fluid leukocyte count

Autori: Thijs M. van Soest, NoraChekrouni, Nina M.van Sorge, Matthijs C.Brouwer, Diederik van de Beek
Pubblicato in: Journal of Infection, Numero Volume 84, Numero 5, May 2022, 2022, Pagina/e 615-620, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.02.029

Otitis in Patients With Community-Acquired Bacterial Meningitis: A Nationwide Prospective Cohort Study

Autori: Martina Ranzenigo, Thijs M van Soest, Erik F Hensen, Paola Cinque, Antonella Castagna, Matthijs C Brouwer, Diederik van de Beek
Pubblicato in: Clinical Infectious Diseases, Numero 79, 2024, Pagina/e 329-335, ISSN 1058-4838
Editore: University of Chicago Press
DOI: 10.1093/cid/ciae221

A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study

Autori: Thijs M van Soest, Liora Ter Horst, Nora Chekrouni, Merijn W Bijlsma, Matthijs C Brouwer, Daniela Urueta Portillo, Diederik van de Beek, Rodrigo Hasbun
Pubblicato in: Clinical microbiology and infection, Numero 29, 2023, Pagina/e 360-365, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.10.001