Improving Prognosis by using innovative methods to diAgnose Causes of Encephalitis

Informazioni relative al progetto

I-PACE

ID dell’accordo di sovvenzione: 101001237

DOI

10.3030/101001237

Data della firma CE 14 Giugno 2021

Data di avvio 1 Dicembre 2021

Data di completamento 30 Novembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 968 996,00

Contributo UE

€ 1 968 996,00

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Drafting of a data management planto be submitted by month 6 of the project

Pubblicazioni

Peer reviewed articles (38)

Validation and clinical implementation of cerebrospinal fluid C-reactive protein for the diagnosis of bacterial meningitis: a prospective diagnostic accuracy study

Autori: Sabine E. Olie, Steven L. Staal, Nina S. Groeneveld, Hans H.M. Schotman, Jacob Bodilsen, Henrik Nielsen, Merijn W. Bijlsma, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: The Lancet Regional Health - Europe, Numero 53, 2025, Pagina/e 101309, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/j.lanepe.2025.101309

Heparin‐Binding Protein in Cerebrospinal Fluid as a Biomarker for Bacterial Meningitis: A Study of Diagnostic Accuracy

Autori: Sabine E. Olie, Steven L. Staal, Ana C. da Cruz Campos, Jacob Bodilsen, Henrik Nielsen, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Annals of Neurology, 2025, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.27193

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Autori: Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, null null, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Annals of Neurology, Numero 98, 2025, Pagina/e 851-863, ISSN 0364-5134
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ana.27291

Anti-cytokine autoantibodies linked to susceptibility, bacterial load, and outcome in pneumococcal meningitis: prospective cohort studies in CNS infections, Alzheimer's disease, and Parkinson's disease

Autori: Rutger Koning, Nora Chekrouni, Lindsey B. Rosen, Marian A. van Roon, Anke A.G. Tolido, Evelien H.G.M. Drost, Dixie Bakker, Steven L. Staal, Sabine E. Olie, Wing Kit Man, Wilma D.J. van de Berg, Yolande A.L. Pijnenburg, Steven M. Holland, Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: eBioMedicine, Numero 121, 2026, Pagina/e 105975, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105975

Diagnostic accuracy of clinical and laboratory characteristics in suspected non-surgical nosocomial central nervous system infections.

Autori: van Zeggeren IE, Pennartz CJ, Ter Horst L, van de Beek D, Brouwer MC; I-PACE Study Group.
Pubblicato in: Journal of Hospital Infections, Numero 145, 2024, Pagina/e 99-105, ISSN 0195-6701
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jhin.2023.12.015

Intracranial pressure management in pneumococcal meningitis: first, do no harm

Autori: Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: Clinical Microbiology and Infection, Numero 31, 2026, Pagina/e 885-887, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2025.03.016

Neurological infections in 2023: surveillance and prevention

Autori: Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Lancet Neurology, Numero 23, 2024, Pagina/e 30-32, ISSN 1474-4422
Editore: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(23)00445-3

VIDISCA-NGS in cerebrospinal fluid of adults with a suspected viral meningoencephalitis

Autori: Steven L. Staal, Sabine E. Olie, Martin Deijs, Arthur W.D. Edridge, Lia van der Hoek, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Journal of Infection, Numero 91, 2026, Pagina/e 106534, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2025.106534

Rabies in humans: A treatment approach

Autori: Cornelis A. De Pijper, Pieter P.A.M. van Thiel, Diederik van de Beek, Matthijs C. Brouwer, Eleonora Aronica, Nicole P. Juffermans, Ron A.A. Mathôt, Corine H. GeurtsvanKessel, Janke Schinkel, Menno D. de Jong, Martin P. Grobusch, Abraham Goorhuis
Pubblicato in: Travel Medicine and Infectious Disease, Numero 64, 2025, Pagina/e 102813, ISSN 1477-8939
Editore: Elsevier BV
DOI: 10.1016/j.tmaid.2025.102813

Intracerebral haemorrhage in bacterial meningitis

Autori: Shahrzad S. Deliran, Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: Journal of infection, Numero 18-06-2022, 2022, Pagina/e S0163-4453(22)00368-1, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.06.013

Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections

Autori: Sabine E. Olie; Steven L. Staal; Liora ter Horst; Ingeborg E. van Zeggeren; Wing K. Man; Michael W.T. Tanck; Diederik van de Beek; Matthijs C. Brouwer
Pubblicato in: Journal of Infection, Numero 2, 2024, Pagina/e 106117, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.01.016

Confused about confusion

Autori: Anne M. Spanjaart, Fleur M. van der Valk, Geeske van Rooijen, Matthijs C. Brouwer, Marie J. Kersten
Pubblicato in: New England Journal of Medicine, Numero 386, 2022, Pagina/e 80-87, ISSN 0028-4793
Editore: Massachusetts Medical Society
DOI: 10.1056/nejmcps2114818.

Increasing incidence of community-acquired adult group A streptococcal meningitis in the Netherlands

Autori: Evelien H G M Drost, Nora Chekrouni, Thijs M van Soest, Kim Schipper, Nina M van Sorge, Matthijs C Brouwer, Diederik van de Beek
Pubblicato in: Journal of Infection, Numero 88(1), 2024, Pagina/e 68-70, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2023.11.007

Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach

Autori: Kinsella, Cormac M; Edridge, Arthur W D; van Zeggeren, Ingeborg E; Deijs, Martin; van de Beek, Diederik; Brouwer, Matthijs C; van der Hoek, Lia
Pubblicato in: Fluids and barriers of the CNS, 19(1):102. BioMed Central, Numero 3, 2022, Pagina/e 102, ISSN 2045-8118
Editore: BioMed Central
DOI: 10.1186/s12987-022-00400-5

Neuronal Autoantibodies in Adults After Community-Acquired Bacterial Meningitis

Autori: Steven L. Staal, Liora Ter Horst, Juliette Brenner, Diederik van de Beek, Maarten J. Titulaer, Matthijs C. Brouwer
Pubblicato in: Neurology Neuroimmunology & Neuroinflammation, Numero 12, 2025, ISSN 2332-7812
Editore: Wolters Kluwer
DOI: 10.1212/nxi.0000000000200454

Granulocytes in cerebrospinal fluid of adults suspected of a central nervous system infection: a prospective study of diagnostic accuracy

Autori: Steven L. Staal, Sabine E. Olie, Liora ter Horst, Ingeborg E. van Zeggeren, Diederik van de Beek, Matthijs C. Brouwer & I.-PACE Study Group
Pubblicato in: Infection, 2024, Pagina/e online ahead of print, ISSN 0300-8126
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02200-5

Seizures in adults with suspected central nervous system infection

Autori: Olie, Sabine E.; van Zeggeren, Ingeborg E.; ter Horst, Liora; Citroen, J.; van Geel, B. M.; Heckenberg, S. G.B.; Jellema, K.; Kester, M. I.; Killestein, J.; Mook, B. B.; Titulaer, M. J.; van Veen, K. E.B.; Verschuur, C. V.M.; van de Beek, Diederik; Brouwer, Matthijs C.
Pubblicato in: BMC neurology, Numero 2, 2022, Pagina/e 426, ISSN 1471-2377
Editore: BioMed Central
DOI: 10.1186/s12883-022-02927-4

Validation of the encephalitis criteria in adults with a suspected central nervous system infection: An updated score

Autori: Steven L. Staal, Sabine E. Olie, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Journal of Infection, Numero 89, 2024, Pagina/e 106239, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2024.106239

Global Case Fatality of Bacterial Meningitis During an 80-Year Period

Autori: Cornelis N. van Ettekoven, Fabian D. Liechti, Matthijs C. Brouwer, Merijn W. Bijlsma, Diederik van de Beek
Pubblicato in: JAMA Network Open, Numero 7, 2024, Pagina/e e2424802, ISSN 2574-3805
Editore: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2024.24802

Neurofilament light chain in central nervous system infections: a prospective study of diagnostic accuracy

Autori: Ingeborg E van Zeggeren, Liora Ter Horst, Hans Heijst, Charlotte E Teunissen, Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Scientific reports, Numero 12, 2022, Pagina/e 14140, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-17643-9

Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy.

Autori: Nina S. Groeneveld; Sabine E. Olie; Douwe H. Visser; Linde Snoek; Diederik van de Beek; Matthijs C. Brouwer; Merijn W. Bijlsma
Pubblicato in: International journal of infectious diseases, Numero 142, 2024, Pagina/e 106970, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/j.ijid.2024.02.013

Biomarkers in paediatric bacterial meningitis: a systematic review and meta-analysis of diagnostic test accuracy

Autori: Nina S. Groeneveld, Merijn W. Bijlsma, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Clinical Microbiology and Infection, 2025, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.12.009

Utility of SIRS criteria and QSOFA score in identifying patients with central nervous system infections at risk for poor outcome

Autori: Yannick C. Resok, Sabine E. Olie, Korné Jellema, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-21163-7

Predictors of unfavourable outcome in adults with suspected central nervous system infections: a prospective cohort study

Autori: Liora Ter Horst, Ingeborg E van Zeggeren, Sabine E Olie; I-PACE Study Group; Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Scientific reports, Numero 13, 2023, Pagina/e 21250, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-48472-z

Diagnosing infectious encephalitis: a narrative review

Autori: Sabine E. Olie, Steven L. Staal, Diederik van de Beek, Matthijs C. Brouwer
Pubblicato in: Clinical Microbiology and Infection, Numero 31, 2025, Pagina/e 522-528, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2024.11.026

Adjunctive dexamethasone treatment in adults with listeria monocytogenes meningitis: a prospective nationwide cohort study

Autori: Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: eClinicalMedicine, Numero 58, 2024, Pagina/e 101922, ISSN 2589-5370
Editore: Elsevier
DOI: 10.1016/j.eclinm.2023.101922

Sex and Gender Differences in Bacterial Infections

Autori: Sara P. Dias; Matthijs C. Brouwer; Diederik van de Beek
Pubblicato in: Infect Immun, Numero 1, 2022, Pagina/e e0028322, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/iai.00283-22

Low Diagnostic Accuracy of Encephalitis Criteria Hinders Interpretation of the Absence of Cerebrospinal Fluid Pleiocytosis

Autori: Steven L Staal, Sabine E Olie, Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: Clinical Infectious Diseases, Numero 81, 2025, Pagina/e e56-e57, ISSN 1058-4838
Editore: University of Chicago Press
DOI: 10.1093/cid/ciaf096

Diagnostic prediction models for bacterial meningitis in children with a suspected central nervous system infection: a systematic review and prospective validation study

Autori: Nina S Groeneveld, Merijn W Bijlsma, Ingeborg E van Zeggeren, Steven L Staal, Michael W T Tanck, Diederik van de Beek, Matthijs C Brouwer
Pubblicato in: BMJ Open, Numero 14, 2025, Pagina/e e081172, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2023-081172

Bacterial meningitis presenting with a normal cerebrospinal fluid leukocyte count

Autori: Thijs M. van Soest, NoraChekrouni, Nina M.van Sorge, Matthijs C.Brouwer, Diederik van de Beek
Pubblicato in: Journal of Infection, Numero Volume 84, Numero 5, May 2022, 2022, Pagina/e 615-620, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.jinf.2022.02.029

Diagnostic Accuracy of Clinical Signs and Biochemical Parameters for External Ventricular CSF Catheter-Associated Infection

Autori: Kirsten R.I.S. Dorresteijn, Rolf J. Verheul, Gabriëlle A.E. Ponjee, Rishi Nandoe Tewarie, Marcella C.A. Müller, Diederik van de Beek, Matthijs C. Brouwer, Korné Jellema
Pubblicato in: Neurology Clinical Practice, Numero 12, 2024, Pagina/e 298-306, ISSN 2163-0402
Editore: Lippincott Williams and Wilkins
DOI: 10.1212/cpj.0000000000200059

Brain Abscesses Complicating Bacterial Meningitis—A Nationwide Cohort Study From the Netherlands

Autori: Fabian D. Liechti, Evelien H. G. M. Drost, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: European Journal of Neurology, Numero 33, 2026, ISSN 1351-5101
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ene.70524

Otitis in Patients With Community-Acquired Bacterial Meningitis: A Nationwide Prospective Cohort Study

Autori: Martina Ranzenigo, Thijs M van Soest, Erik F Hensen, Paola Cinque, Antonella Castagna, Matthijs C Brouwer, Diederik van de Beek
Pubblicato in: Clinical Infectious Diseases, Numero 79, 2024, Pagina/e 329-335, ISSN 1058-4838
Editore: University of Chicago Press
DOI: 10.1093/cid/ciae221

Diagnostic Yield of Anti‐Neuronal Antibody Testing in Patients Suspected of an Infectious Encephalitis

Autori: Liora ter Horst, Juliette Brenner, Ingeborg E. van Zeggeren, null null, Diederik van de Beek, Maarten J. Titulaer, Matthijs C. Brouwer
Pubblicato in: European Journal of Neurology, Numero 32, 2025, ISSN 1351-5101
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ene.70359

Clinical features and outcomes of <i>Staphylococcus aureus</i> brain abscess in Denmark and the Netherlands: a multicentre cohort study

Autori: Emilie Marie Eriksen, Merijn Bijlsma, Sabine Olie, Lykke Larsen, Merete Storgaard, Helene Mens, Henrik Nielsen, Matthijs Brouwer, Jacob Bodilsen, null null
Pubblicato in: Infectious Diseases, Numero 58, 2026, Pagina/e 507-517, ISSN 2374-4235
Editore: Informa UK Limited
DOI: 10.1080/23744235.2025.2607395

Effect of the COVID-19 pandemic on clinical characteristics and outcomes of adult pneumococcal meningitis patients – a Dutch prospective nationwide cohort study

Autori: Fabian D. Liechti, Merijn W. Bijlsma, Matthijs C. Brouwer, Diederik van de Beek
Pubblicato in: Infection, Numero 52, 2024, Pagina/e 1657-1662, ISSN 0300-8126
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02305-x

A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study

Autori: Thijs M van Soest, Liora Ter Horst, Nora Chekrouni, Merijn W Bijlsma, Matthijs C Brouwer, Daniela Urueta Portillo, Diederik van de Beek, Rodrigo Hasbun
Pubblicato in: Clinical microbiology and infection, Numero 29, 2023, Pagina/e 360-365, ISSN 1198-743X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2022.10.001

Sex differences in bacterial meningitis and associations with socioeconomic indicators: a systematic review and meta-analysis with metaregression

Autori: Fabian D Liechti, Cornelis N van Ettekoven, Matthijs C Brouwer, Merijn Bijlsma, Diederik van de Beek
Pubblicato in: BMJ Global Health, Numero 10, 2025, Pagina/e e016802, ISSN 2059-7908
Editore: BMJ
DOI: 10.1136/bmjgh-2024-016802