From the understanding of KRAS-RAF membrane dynamics to new therapeutic strategies in cancer

Project Information

KARMA

Grant agreement ID: 101001288

DOI

10.3030/101001288

EC signature date 1 February 2021

Start date 1 August 2021

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 996 853,00

EU contribution

€ 1 996 853,00

Coordinated by

UNIVERSITA DEGLI STUDI DI TORINO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer

Author(s): Entrialgo-Cadierno, Rodrigo; Cueto-Ureña, Cristina; Welch, Connor; Feliu, Iker; Macaya, Irati; Vera, Laura; Morales, Xabier; Michelina, Sandra Vietti; Scaparone, Pietro; Lopez, Ines; Darbo, Elodie; Erice, Oihane; Vallejo, Adrian; Moreno, Haritz; Goñi-Salaverri, Ainhoa; Lara-Astiaso, David; Halberg, Nils; Cortes-Dominguez, Ivan; Guruceaga, Elizabeth; Ambrogio, Chiara; Lecanda, Fernando; Vicent,
Published in: Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023), Issue 2, 2023, ISSN 1476-4598
Publisher: BioMed Central
DOI: 10.1186/s12943-023-01788-w

Structural model of a Ras-Raf signalosome

Author(s): Mysore VP*, Zhou Z*, Ambrogio C*, Wang Q, Okoro J, Jänne PA, Westover KD, Shan Y, Shaw DE
Published in: Nature Structural and Molecular Biology, 2021, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00667-6

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Author(s): Mallika Singh; Matthew Holderfield; Bianca Lee; Jingjing Jiang; Aidan Tomlinson; Kyle Seamon; Alessia Mira; Enricho Patrucco; Grace Goodhart; Julien Dilly; Yevgeniy Gindin; Nuntana Dinglasan; Ying Wang; Lick Pui Lai; Shurui Cai; Lingyan Jiang; Yu Yang; Nicole Nasholm; James Evans; Nilufar Montazer; Oliver Lai; Jade Shi; Ethan Ahler; Stephanie Chang; Anthony Salvador; Abby Marquez; Jim Cregg; Yang
Published in: Nature, Issue 1, 2024, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3122478/v1

Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer

Author(s): Biagio Ricciuti, Jieun Son, Jeffrey J Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J Redig, Jens Köhler, Kshiti H Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C Gokhale, Mark M Awad, Pasi A Jänne, Chiara Ambrogio
Published in: Clinical Cancer Research, 2022, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-21-2719

RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

Author(s): Marie-Julie Nokin, Alessia Mira, Enrico Patrucco, Biagio Ricciuti, Sophie Cousin, Isabelle Soubeyran, Sonia San José, Serena Peirone, Livia Caizzi, Sandra Vietti Michelina, Aurelien Bourdon, Xinan Wang, Daniel Alvarez-Villanueva, María Martínez-Iniesta, August Vidal, Telmo Rodrigues, Carmen García-Macías, Mark M. Awad, Ernest Nadal, Alberto Villanueva, Antoine Italiano, Matteo Cereda, David S
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51828-2

Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models

Author(s): Elisabetta Puliga, Chiara De Bellis, Sandra Vietti Michelina, Tania Capeloa, Cristina Migliore, Claudia Orrù, Gian Luca Baiocchi, Giovanni De Manzoni, Filippo Pietrantonio, Rossella Reddavid, Uberto Fumagalli Romario, Chiara Ambrogio, Simona Corso, Silvia Giordano
Published in: Gastric Cancer, 2024, ISSN 1436-3305
Publisher: Springer
DOI: 10.1007/s10120-024-01468-8

Novel RAF-directed approaches to overcome current clinical limits and block the RAS/RAF node

Author(s): Rossella Scardaci, Ewa Berlinska, Pietro Scaparone, Sandra Vietti Michelina, Edoardo Garbo, Silvia Novello, David Santamaria, Chiara Ambrogio
Published in: Molecular Oncology, 2024, ISSN 1878-0261
Publisher: FEBS PRESS
DOI: 10.1002/1878-0261.13605

In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

Author(s): Marie-Julie Nokin, Elodie Darbo, Elodie Richard, Sonia San José, Sergio de Hita, Valérie Prouzet-Mauleon, Béatrice Turcq, Laura Gerardelli, Rebekah Crake, Valérie Velasco, Benjamin Koopmansch, Frederic Lambert, Jenny Y. Xue, Ben Sang, Julie Horne, Eric Ziemons, Alberto Villanueva, Arnaud Blomme, Michael Herfs, Didier Cataldo, Olivier Calvayrac, Paolo Porporato, Ernest Nadal, Piro Lito, Pasi A.
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101663, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2024.101663

Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases

Author(s): Marcin Nicoś, Luuk Harbers, Enrico Patrucco, Maximilian Kramer-Drauberg, Xiaolu Zhang 1 2 5 , Claudia Voena 4 , Anna Kowalczyk 6 7 , Aleksandra Bożyk 3 , Rafał Pęksa 7 8 , Bożena Jarosz 7 9 , Justyna Szumiło 10 , Michele Simonetti 1 2 , Monika Żuk 11 , Bartosz Wasąg 11 , Katarzyna Reszka 12 , Renata Duchnowska 7 13 , Janusz Milanowski 3 , Roberto Chiarle 4 14
Published in: JTO Clin Res Rep, 2022, ISSN 2666-3643
Publisher: New York: Elsevier Inc.
DOI: 10.1016/j.jtocrr.2022.100435

Non-peer reviewed articles (1)

Exploiting signaling rewiring in cancer cells with co‐existing oncogenic drivers

Author(s): Roberto Chiarle; Chiara Ambrogio
Published in: Molecular Oncology, Vol 17, Iss 11, Pp 2215-2217 (2023), Issue 2, 2023, ISSN 1878-0261
Publisher: Elsevier
DOI: 10.1002/1878-0261.13547