From the understanding of KRAS-RAF membrane dynamics to new therapeutic strategies in cancer

Publikacje

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer

Autorzy: Entrialgo-Cadierno, Rodrigo; Cueto-Ureña, Cristina; Welch, Connor; Feliu, Iker; Macaya, Irati; Vera, Laura; Morales, Xabier; Michelina, Sandra Vietti; Scaparone, Pietro; Lopez, Ines; Darbo, Elodie; Erice, Oihane; Vallejo, Adrian; Moreno, Haritz; Goñi-Salaverri, Ainhoa; Lara-Astiaso, David; Halberg, Nils; Cortes-Dominguez, Ivan; Guruceaga, Elizabeth; Ambrogio, Chiara; Lecanda, Fernando; Vicent,
Opublikowane w: Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023), Numer 2, 2023, ISSN 1476-4598
Wydawca: BioMed Central
DOI: 10.1186/s12943-023-01788-w

Structural model of a Ras-Raf signalosome

Autorzy: Mysore VP*, Zhou Z*, Ambrogio C*, Wang Q, Okoro J, Jänne PA, Westover KD, Shan Y, Shaw DE
Opublikowane w: Nature Structural and Molecular Biology, 2021, ISSN 1545-9993
Wydawca: Nature Publishing Group
DOI: 10.1038/s41594-021-00667-6

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Autorzy: Mallika Singh; Matthew Holderfield; Bianca Lee; Jingjing Jiang; Aidan Tomlinson; Kyle Seamon; Alessia Mira; Enricho Patrucco; Grace Goodhart; Julien Dilly; Yevgeniy Gindin; Nuntana Dinglasan; Ying Wang; Lick Pui Lai; Shurui Cai; Lingyan Jiang; Yu Yang; Nicole Nasholm; James Evans; Nilufar Montazer; Oliver Lai; Jade Shi; Ethan Ahler; Stephanie Chang; Anthony Salvador; Abby Marquez; Jim Cregg; Yang
Opublikowane w: Nature, Numer 1, 2024, ISSN 1476-4687
Wydawca: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3122478/v1

Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer

Autorzy: Biagio Ricciuti, Jieun Son, Jeffrey J Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J Redig, Jens Köhler, Kshiti H Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C Gokhale, Mark M Awad, Pasi A Jänne, Chiara Ambrogio
Opublikowane w: Clinical Cancer Research, 2022, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-21-2719

Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer models

Autorzy: Elisabetta Puliga, Chiara De Bellis, Sandra Vietti Michelina, Tania Capeloa, Cristina Migliore, Claudia Orrù, Gian Luca Baiocchi, Giovanni De Manzoni, Filippo Pietrantonio, Rossella Reddavid, Uberto Fumagalli Romario, Chiara Ambrogio, Simona Corso, Silvia Giordano
Opublikowane w: Gastric Cancer, Numer 27, 2024, ISSN 1436-3305
Wydawca: Springer
DOI: 10.1007/s10120-024-01468-8

Novel RAF-directed approaches to overcome current clinical limits and block the RAS/RAF node

Autorzy: Rossella Scardaci, Ewa Berlinska, Pietro Scaparone, Sandra Vietti Michelina, Edoardo Garbo, Silvia Novello, David Santamaria, Chiara Ambrogio
Opublikowane w: Molecular Oncology, 2024, ISSN 1878-0261
Wydawca: FEBS PRESS
DOI: 10.1002/1878-0261.13605

Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases

Autorzy: Marcin Nicoś, Luuk Harbers, Enrico Patrucco, Maximilian Kramer-Drauberg, Xiaolu Zhang 1 2 5 , Claudia Voena 4 , Anna Kowalczyk 6 7 , Aleksandra Bożyk 3 , Rafał Pęksa 7 8 , Bożena Jarosz 7 9 , Justyna Szumiło 10 , Michele Simonetti 1 2 , Monika Żuk 11 , Bartosz Wasąg 11 , Katarzyna Reszka 12 , Renata Duchnowska 7 13 , Janusz Milanowski 3 , Roberto Chiarle 4 14
Opublikowane w: JTO Clin Res Rep, Numer VOL 3 (12), 2022, ISSN 2666-3643
Wydawca: New York: Elsevier Inc.
DOI: 10.1016/j.jtocrr.2022.100435

Exploiting signaling rewiring in cancer cells with co‐existing oncogenic drivers

Autorzy: Roberto Chiarle; Chiara Ambrogio
Opublikowane w: Molecular Oncology, Vol 17, Iss 11, Pp 2215-2217 (2023), Numer 2, 2023, ISSN 1878-0261
Wydawca: Elsevier
DOI: 10.1002/1878-0261.13547

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