AI-augmented, Multiscale Image-based Diagnostics of Chronic Kidney Disease

Project Information

AIM.imaging.CKD

Grant agreement ID: 101001791

DOI

10.3030/101001791

EC signature date 1 February 2021

Start date 1 May 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 375,00

EU contribution

€ 1 999 375,00

Coordinated by

UNIVERSITAETSKLINIKUM AACHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

Multi-institutional PET/CT image segmentation using federated deep transformer learning

Author(s): Shiri I, Razeghi B, Vafaei Sadr A, Amini M, Salimi Y, Ferdowsi S, Boor P, Gündüz D, Voloshynovskiy S, Zaidi H
Published in: Comput Methods Programs Biomed, 2023, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2023.107706

Extending the landscape of omics technologies by pathomics

Author(s): Bülow RD, Hölscher DL, Costa IG, Boor P
Published in: NPJ Syst Biol Appl., 2023, ISSN 2056-7189
Publisher: Springer Nature
DOI: 10.1038/s41540-023-00301-9

Kidney fibrosis: Emerging diagnostic and therapeutic strategies

Author(s): Klinkhammer BM, Boor P
Published in: Mol Aspects Med., 2023, ISSN 0098-2997
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2023.101206

Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD

Author(s): Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, Mauz M, Markwirth P, Wong DWL, Boor P, Kazakov A, Mollenhauer M, Linz B, Klinkhammer BM, Hübner U, Ukena C, Moellmann J, Lehrke M, Wagenpfeil S, Werner C, Linz D, Mahfoud F, Böhm M
Published in: Circ Res, 2022, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.320104

Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria

Author(s): Gianmoena K, Gasparoni N, Jashari A, Gabrys P, Grgas K, Ghallab A, Nordström K, Gasparoni G, Reinders J, Edlund K, Godoy P, Schriewer A, Hayen H, Hudert CA, Damm G, Seehofer D, Weiss TS, Boor P, Anders H-J, Motrapu M, Jansen P, Schiergens TS, Falk-Paulsen M, Rosenstiel P, Lisowski C, Salido E, Marchan R, Walter J, Hengstler JG, Cadenas C
Published in: Cell Rep, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109526

Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney disease

Author(s): Klinkhammer BM, Buchtler S, Djudjaj S, Bouteldja N, Palsson R, Edvardsson VO, Thorsteinsdottir M, Floege J, Mack M, Boor P
Published in: Kidney Int., 2022, ISSN 0085-2538
Publisher: Blackwell Publishing Inc.
DOI: 10.18154/rwth-conv-249847

CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes

Author(s): Olschok K, Han L, de Toledo MAS, Böhnke J, Graßhoff M, Costa IG, Theocharides A, Maurer A, Schüler HM, Buhl EM, Pannen K, Baumeister J, Kalmer M, Gupta S, Boor P, Gezer D, Brümmendorf TH, Zenke M, Chatain N, Koschmieder S
Published in: Stem Cell Reports, 2021, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2021.09.019

Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations

Author(s): Anders HJ, Boor P
Published in: J Am Soc Nephrol., 2022, ISSN 1555-9041
Publisher: American Society of Nephrology
DOI: 10.1681/asn.2022040506

Stain-Independent Deep Learning-Based Analysis of Digital Kidney Histopathology

Author(s): Bouteldja N, Hölscher DL, Klinkhammer BM, Buelow RD, Lotz J, Weiss N, Daniel C, Amann K, Boor P
Published in: Am J Pathol., 2023, ISSN 0002-9440
Publisher: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2022.09.011

Deep Learning-based classification of kidney transplant pathology: a retrospective, multicente, proof-of-concept study

Author(s): "Kers J#, Bülow RD#, Klinkhammer BM, Breimer GE, Fontana F, Abiola AA, Hofstraat R, Corthals GL, Sengers HP, Djudjaj S, von Stillfried S, Hölscher DL, Pieters TT, van Zuilen AD, Bemelman FJ, Nurmohamed AS, Naesens M, Roelofs JJTH, Florquin S, Floege J, Nguyen TQ, Kather JN, Boor P"
Published in: Lancet Digit Health., 2022, ISSN 2589-7500
Publisher: Oxford: Elsevier Ltd.
DOI: 10.1016/s2589-7500(21)00211-9

Deep Learning for the detection of microsatellite instability from histology images in colorectal cancer: a systematic literature review

Author(s): Echle A, Laleh NG, Schrammen PL, West NP, Trautwein C, Brinker TJ, Gruber SB, Buelow RD, Boor P, Grabsch HI, Quirke P, Kather JN
Published in: J Immuno, 2021, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.3390/cancers13030391

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Author(s): Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Deutsche COVID-19 OMIC
Published in: Cell, 2021, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.11.033

Inhibition of the Renal Apical Sodium Dependent Bile Acid Transporter Prevents Cholemic Nephropathy in Mice with Obstructive Cholestasis

Author(s): Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Ma
Published in: J Hepatol, 2023, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2023.10.035

Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology

Author(s): Ghaffari Laleh N, Muti HS, Loeffler CML, Echle A, Saldanha OL, Mahmood F, Lu MY, Trautwein C, Langer R, Dislich B, Buelow RD, Grabsch HI, Brenner H, Chang-Claude J, Alwers E, Brinker TJ, Khader F, Truhn D, Gaisa NT, Boor P, Hoffmeister M, Schulz V, Kather JN
Published in: Med Image Anal., 2022, ISSN 1361-8415
Publisher: Elsevier BV
DOI: 10.1016/j.media.2022.102474

Operational greenhouse-gas emissions of deep learning in digital pathology: a modelling study

Author(s): Vafaei Sadr A, Bülow R, von Stillfried S, Schmitz NEJ, Pilva P, Hölscher DL, Ha PP, Schweiker M, Boor P
Published in: Lancet Digit Health, 2023, ISSN 2589-7500
Publisher: Oxford: Elsevier Ltd.
DOI: 10.1016/s2589-7500(23)00219-4

The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis

Author(s): Ting Jia, Tong Xu, Bart Smeets, Eva Miriam Buhl, Marcus Johannes Moeller, Jürgen Floege, Barbara Mara Klinkhammer, Peter Boor
Published in: J Am Soc Nephrol, 2023, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2022040491

Inflammation and vascular remodeling in COVID-19 hearts

Author(s): Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ, Boor P, Black SM, Länger F, Kuehnel M, Jonigk D
Published in: Angiogenesis, 2022, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-022-09860-7

Mapping cardiac remodeling in chronic kidney disease

Author(s): Kaesler N, Cheng M, Nagai J, O'Sullivan J, Peisker F, Bindels EMJ, Babler A, Moellmann J, Droste P, Franciosa G, Dugourd A, Saez-Rodriguez J, Neuss S, Lehrke M, Boor P, Goettsch C, Olsen JV, Speer T, Lu TS, Lim K, Floege J, Denby L, Costa I, Kramann R
Published in: Sci Adv, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adj4846

Tackling stain variability using CycleGAN-based stain augmentation

Author(s): Bouteldja N, Hölscher DL, Bülow RD, Roberts ISD, Coppo R, Boor P
Published in: J Pathol Inform., 2022, ISSN 2229-5089
Publisher: Medknow publication
DOI: 10.1016/j.jpi.2022.100140

The potential of artificial intelligence-based applications in kidney pathology

Author(s): Bülow RD, Marsh JN, Swamidass J, Gaut JP, Boor P
Published in: Curr Opin Nephrol Hypertens, 2022, ISSN 1062-4821
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnh.0000000000000784

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.

Author(s): Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Ko
Published in: Nat Commun, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38663-7

Subcellular spatio-temporal intravital kinetics of aflatoxin B 1 and ochratoxin A in liver and kidney

Author(s): Ghallab A, Hassan R, Myllys M, Albrecht W, Friebel A, Hoehme S, Hofmann U, Seddek A-L, Braeuning A, Kuepfer L, Cramer B, Humpf H-U, Boor P, Degen GH, Hengstler JG
Published in: Arch Toxicol, 2021, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-021-03073-5

Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments

Author(s): Farris AB, Alexander MP, Balis UGJ, Barisoni L, Boor P, Bülow RD, Cornell LD, Demetris AJ, Farkash E, Hermsen M, Hogan J, Kain R, Kers J, Kong J, Levenson RM, Loupy A, Naesens M, Sarder P, Tomaszewski JE, van der Laak J, van Midden D, Yagi Y, Solez K
Published in: Transpl Int., 2023, ISSN 0934-0874
Publisher: Blackwell Publishing Inc.
DOI: 10.18154/rwth-conv-247345

Interleukin-1α (IL-1α) is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease

Author(s): Schunk S, Triem S, Schmit D, Zewinger S, Sarakpi T, Becker E, Hütter G, Wrublewsky S, Küting F, Hohl M, Alansary D, Roma LP, Lipp P, Möllmann J, Lehrke M, Laschke MW, Menger MD, Kramann R, Boor P, Jahnen-Dechent W, März W, Böhm M, Laufs U, Niemeyer BA, Fliser D, Ampofo E, Speer T
Published in: Circulation, 2021, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.121.053547