AI-augmented, Multiscale Image-based Diagnostics of Chronic Kidney Disease

Información del proyecto

AIM.imaging.CKD

Identificador del acuerdo de subvención: 101001791

DOI

10.3030/101001791

Fecha de la firma de la CE 1 Febrero 2021

Fecha de inicio 1 Mayo 2021

Fecha de finalización 30 Abril 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 375,00

Aportación de la UE

€ 1 999 375,00

Coordinado por

UNIVERSITAETSKLINIKUM AACHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (24)

Multi-institutional PET/CT image segmentation using federated deep transformer learning

Autores: Shiri I, Razeghi B, Vafaei Sadr A, Amini M, Salimi Y, Ferdowsi S, Boor P, Gündüz D, Voloshynovskiy S, Zaidi H
Publicado en: Comput Methods Programs Biomed, 2023, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2023.107706

Extending the landscape of omics technologies by pathomics

Autores: Bülow RD, Hölscher DL, Costa IG, Boor P
Publicado en: NPJ Syst Biol Appl., 2023, ISSN 2056-7189
Editor: Springer Nature
DOI: 10.1038/s41540-023-00301-9

Kidney fibrosis: Emerging diagnostic and therapeutic strategies

Autores: Klinkhammer BM, Boor P
Publicado en: Mol Aspects Med., 2023, ISSN 0098-2997
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2023.101206

Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD

Autores: Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, Mauz M, Markwirth P, Wong DWL, Boor P, Kazakov A, Mollenhauer M, Linz B, Klinkhammer BM, Hübner U, Ukena C, Moellmann J, Lehrke M, Wagenpfeil S, Werner C, Linz D, Mahfoud F, Böhm M
Publicado en: Circ Res, 2022, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.320104

Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria

Autores: Gianmoena K, Gasparoni N, Jashari A, Gabrys P, Grgas K, Ghallab A, Nordström K, Gasparoni G, Reinders J, Edlund K, Godoy P, Schriewer A, Hayen H, Hudert CA, Damm G, Seehofer D, Weiss TS, Boor P, Anders H-J, Motrapu M, Jansen P, Schiergens TS, Falk-Paulsen M, Rosenstiel P, Lisowski C, Salido E, Marchan R, Walter J, Hengstler JG, Cadenas C
Publicado en: Cell Rep, 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109526

Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney disease

Autores: Klinkhammer BM, Buchtler S, Djudjaj S, Bouteldja N, Palsson R, Edvardsson VO, Thorsteinsdottir M, Floege J, Mack M, Boor P
Publicado en: Kidney Int., 2022, ISSN 0085-2538
Editor: Blackwell Publishing Inc.
DOI: 10.18154/rwth-conv-249847

CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes

Autores: Olschok K, Han L, de Toledo MAS, Böhnke J, Graßhoff M, Costa IG, Theocharides A, Maurer A, Schüler HM, Buhl EM, Pannen K, Baumeister J, Kalmer M, Gupta S, Boor P, Gezer D, Brümmendorf TH, Zenke M, Chatain N, Koschmieder S
Publicado en: Stem Cell Reports, 2021, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2021.09.019

Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations

Autores: Anders HJ, Boor P
Publicado en: J Am Soc Nephrol., 2022, ISSN 1555-9041
Editor: American Society of Nephrology
DOI: 10.1681/asn.2022040506

Stain-Independent Deep Learning-Based Analysis of Digital Kidney Histopathology

Autores: Bouteldja N, Hölscher DL, Klinkhammer BM, Buelow RD, Lotz J, Weiss N, Daniel C, Amann K, Boor P
Publicado en: Am J Pathol., 2023, ISSN 0002-9440
Editor: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2022.09.011

Deep Learning-based classification of kidney transplant pathology: a retrospective, multicente, proof-of-concept study

Autores: "Kers J#, Bülow RD#, Klinkhammer BM, Breimer GE, Fontana F, Abiola AA, Hofstraat R, Corthals GL, Sengers HP, Djudjaj S, von Stillfried S, Hölscher DL, Pieters TT, van Zuilen AD, Bemelman FJ, Nurmohamed AS, Naesens M, Roelofs JJTH, Florquin S, Floege J, Nguyen TQ, Kather JN, Boor P"
Publicado en: Lancet Digit Health., 2022, ISSN 2589-7500
Editor: Oxford: Elsevier Ltd.
DOI: 10.1016/s2589-7500(21)00211-9

Deep Learning for the detection of microsatellite instability from histology images in colorectal cancer: a systematic literature review

Autores: Echle A, Laleh NG, Schrammen PL, West NP, Trautwein C, Brinker TJ, Gruber SB, Buelow RD, Boor P, Grabsch HI, Quirke P, Kather JN
Publicado en: J Immuno, 2021, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.3390/cancers13030391

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Autores: Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Deutsche COVID-19 OMIC
Publicado en: Cell, 2021, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2021.11.033

Inhibition of the Renal Apical Sodium Dependent Bile Acid Transporter Prevents Cholemic Nephropathy in Mice with Obstructive Cholestasis

Autores: Ghallab A, González D, Strängberg E, Hofmann U, Myllys M, Hassan R, Hobloss Z, Brackhagen L, Begher-Tibbe B, Duda JC, Drenda C, Kappenberg F, Reinders J, Friebel A, Vucur M, Turajski M, Seddek AL, Abbas T, Abdelmageed N, Morad SAF, Morad W, Hamdy A, Albrecht W, Kittana N, Assali M, Vartak N, van Thriel C, Sous A, Nell P, Villar-Fernandez M, Cadenas C, Genc E, Marchan R, Luedde T, Åkerblad P, Ma
Publicado en: J Hepatol, 2023, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/j.jhep.2023.10.035

Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology

Autores: Ghaffari Laleh N, Muti HS, Loeffler CML, Echle A, Saldanha OL, Mahmood F, Lu MY, Trautwein C, Langer R, Dislich B, Buelow RD, Grabsch HI, Brenner H, Chang-Claude J, Alwers E, Brinker TJ, Khader F, Truhn D, Gaisa NT, Boor P, Hoffmeister M, Schulz V, Kather JN
Publicado en: Med Image Anal., 2022, ISSN 1361-8415
Editor: Elsevier BV
DOI: 10.1016/j.media.2022.102474

Operational greenhouse-gas emissions of deep learning in digital pathology: a modelling study

Autores: Vafaei Sadr A, Bülow R, von Stillfried S, Schmitz NEJ, Pilva P, Hölscher DL, Ha PP, Schweiker M, Boor P
Publicado en: Lancet Digit Health, 2023, ISSN 2589-7500
Editor: Oxford: Elsevier Ltd.
DOI: 10.1016/s2589-7500(23)00219-4

The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis

Autores: Ting Jia, Tong Xu, Bart Smeets, Eva Miriam Buhl, Marcus Johannes Moeller, Jürgen Floege, Barbara Mara Klinkhammer, Peter Boor
Publicado en: J Am Soc Nephrol, 2023, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2022040491

Inflammation and vascular remodeling in COVID-19 hearts

Autores: Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ, Boor P, Black SM, Länger F, Kuehnel M, Jonigk D
Publicado en: Angiogenesis, 2022, ISSN 0969-6970
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10456-022-09860-7

Mapping cardiac remodeling in chronic kidney disease

Autores: Kaesler N, Cheng M, Nagai J, O'Sullivan J, Peisker F, Bindels EMJ, Babler A, Moellmann J, Droste P, Franciosa G, Dugourd A, Saez-Rodriguez J, Neuss S, Lehrke M, Boor P, Goettsch C, Olsen JV, Speer T, Lu TS, Lim K, Floege J, Denby L, Costa I, Kramann R
Publicado en: Sci Adv, 2023, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adj4846

Tackling stain variability using CycleGAN-based stain augmentation

Autores: Bouteldja N, Hölscher DL, Bülow RD, Roberts ISD, Coppo R, Boor P
Publicado en: J Pathol Inform., 2022, ISSN 2229-5089
Editor: Medknow publication
DOI: 10.1016/j.jpi.2022.100140

The potential of artificial intelligence-based applications in kidney pathology

Autores: Bülow RD, Marsh JN, Swamidass J, Gaut JP, Boor P
Publicado en: Curr Opin Nephrol Hypertens, 2022, ISSN 1062-4821
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/mnh.0000000000000784

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.

Autores: Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Ko
Publicado en: Nat Commun, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38663-7

Subcellular spatio-temporal intravital kinetics of aflatoxin B 1 and ochratoxin A in liver and kidney

Autores: Ghallab A, Hassan R, Myllys M, Albrecht W, Friebel A, Hoehme S, Hofmann U, Seddek A-L, Braeuning A, Kuepfer L, Cramer B, Humpf H-U, Boor P, Degen GH, Hengstler JG
Publicado en: Arch Toxicol, 2021, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-021-03073-5

Banff Digital Pathology Working Group: Image Bank, Artificial Intelligence Algorithm, and Challenge Trial Developments

Autores: Farris AB, Alexander MP, Balis UGJ, Barisoni L, Boor P, Bülow RD, Cornell LD, Demetris AJ, Farkash E, Hermsen M, Hogan J, Kain R, Kers J, Kong J, Levenson RM, Loupy A, Naesens M, Sarder P, Tomaszewski JE, van der Laak J, van Midden D, Yagi Y, Solez K
Publicado en: Transpl Int., 2023, ISSN 0934-0874
Editor: Blackwell Publishing Inc.
DOI: 10.18154/rwth-conv-247345

Interleukin-1α (IL-1α) is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease

Autores: Schunk S, Triem S, Schmit D, Zewinger S, Sarakpi T, Becker E, Hütter G, Wrublewsky S, Küting F, Hohl M, Alansary D, Roma LP, Lipp P, Möllmann J, Lehrke M, Laschke MW, Menger MD, Kramann R, Boor P, Jahnen-Dechent W, März W, Böhm M, Laufs U, Niemeyer BA, Fliser D, Ampofo E, Speer T
Publicado en: Circulation, 2021, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.121.053547