Regulatory and functional architecture of 'Nested-Sensitivity' microexon programs

Project Information

NESTEDMICS

Grant agreement ID: 101002275

DOI

10.3030/101002275

Project closed

EC signature date 7 May 2021

Start date 1 July 2021

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 974 541,00

EU contribution

€ 1 974 541,00

Coordinated by

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4

Author(s): Sophie Bonnal, Simon Bajew, Rosa Martinez-Corral, Manuel Irimia
Published in: Nature Structural & Molecular Biology, 2026, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1101/2024.09.17.613571

Parallel evolution of a splicing program controlling neuronal excitability in flies and mammals

Author(s): Torres-Méndez, A., Pop, S., Bonnal, S., Almudi, I., Roberts, R.J.V., Paolantoni, C., Alcaina, A., Avola, A., Martín-Anduaga, A., Haussmann, I.U., Morin, V., Casares, F., Soller, M., Kadener, S., Roignant, J.-Y., Prieto-Godino, L., Irimia, M.
Published in: Science Advances, Issue 8, 2022, Page(s) eabk0445, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abk0445

Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish

Author(s): Tahnee Mackensen, Luis Pedro Iñiguez, Thomas Soares Mullen, Cristina Rodriguez-Marin, François Kroll, Giulia Zuccarini, Jordi Fernandez-Albert, Laia Sancho-Vila, Jon Permanyer, Isaac H. Bianco, Michael Orger, Jason Rihel, Manuel Irimia
Published in: Science Advances, Issue 12, 2026, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ady8291

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

Author(s): Patryk Poliński, Marta Miret Cuesta, Alfonsa Zamora-Moratalla, Federica Mantica, Gerard Cantero-Recasens, Davide Normanno, Luis P. Iñiguez, Cruz Morenilla-Palao, Patricia Ordoño, Sophie Bonnal, Jonathan D Ellis, Raúl Gómez Riera, María Martínez De Lagrán Cabredo, Álvaro Fernández-Blanco, Cristina Rodríguez-Marin, Jon Permanyer, Orsolya Fölsz, Eduardo Dominguez-Sala, Cesar Sierra, Diana
Published in: Nature Communications, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2023.01.12.523772

Unique transcriptomes of sensory and non-sensory neurons: insights from Splicing Regulatory States

Author(s): Ludovica Ciampi, Luis Serrano, Manuel Irimia
Published in: Molecular Systems Biology, Issue 20, 2024, Page(s) 296-310, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.1038/s44320-024-00020-1

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

Author(s): Patryk Poliński, Marta Miret Cuesta, Alfonsa Zamora-Moratalla, Federica Mantica, Gerard Cantero-Recasens, Carlotta Viana, Miguel Sabariego-Navarro, Davide Normanno, Luis P. Iñiguez, Cruz Morenilla-Palao, Patricia Ordoño, Sophie Bonnal, Jonathan D. Ellis, Raúl Gómez-Riera, Hugo Fanlo-Ucar, Dominic S. Yap, María Martínez De Lagrán, Álvaro Fernández-Blanco, Cristina Rodríguez-Marin, Jon Pe
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-59430-w

<i>Insplico</i>: Effective computational tool for studying intron splicing order genome-wide with short and long RNA-seq reads

Author(s): Andre Gohr; Antonio Torres-Méndez; Sophie Bonnal; Manuel Irimia
Published in: Nucleic Acids Research, Issue 51, 2023, Page(s) e56, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1101/2022.08.15.503947

Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision.

Author(s): Ciampi, L., Mantica, F., Lopez-Blanch, L., Rodríguez-Marin, C., Cianferoni, D., Zang, J., Permanyer, J., Jiménez-Delgado, S., Bonnal, S., Miravet-Verde, S., Ruprecht, V., Neuhauss, S.C.F., Banfi, S., Carrella, S., Serrano, L., Head, S.A., Irimia, M.
Published in: Proc Natl Acad Sci U S A, Issue 119(29), 2022, Page(s) e2117090119, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2117090119

From Tiny Exons to Big Insights: The Expanding Field of Microexons

Author(s): Tahnee Mackensen, Manuel Irimia
Published in: Annual Review of Genomics and Human Genetics, Issue 26, 2026, Page(s) 77-102, ISSN 1527-8204
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-genom-121323-103648

Evolutionary diversification of ancestral genes across vertebrates and insects

Author(s): Federica Mantica, Manuel Irimia
Published in: Genome Biology, 2026, ISSN 1474-760X
Publisher: BioMed Central (Springer Nature)
DOI: 10.1101/2024.06.11.598551

Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

Author(s): Laura Lopez-Blanch, Cristina Rodríguez-Marin, Federica Mantica, Luis P Iñiguez, Jon Permanyer, Elizabeth M Kita, Tahnee Mackensen, Mireia Codina-Tobias, Francisco Romero-Ferrero, Jordi Fernandez-Albert, Myriam Cuadrado, Xosé R Bustelo, Gonzalo de Polavieja, Manuel Irimia
Published in: eLife, Issue 13, 2026, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.104275.3

Genetic regulation of RNA splicing in human pancreatic islets

Author(s): Goutham Atla; Silvia Bonàs-Guarch; Mirabai Cuenca-Ardura; Anthony Beucher; Daniel J. M. Crouch; Javier Garcia-Hurtado; Ignasi Moran; Miriam Cnop; Lena Eliasson; Jonathan Lou S. Esguerra; Décio L. Eizirik; Leif Groop; Thomas S. Jensen; Torben Hansen; Piero Marchetti; Josep M. Mercader; Hindrik Mulder; Chris R. Stabile-Barnett; Christian Thirion; David Torrents; Manuel Irimia; Rashmi B. Prasad; An
Published in: Genome Biology, 23(1). BMC, Issue 2, 2022, ISSN 1474-760X
Publisher: BMC
DOI: 10.1186/s13059-022-02757-0

Pancreatic microexons regulate islet function and glucose homeostasis

Author(s): Jonàs Juan-Mateu, Simon Bajew, Luis P. Íñiguez, Amaya Lopez-Pascual, Sophie Bonnal, Goutham Atla, Sílvia Bonàs-Guarch, Jorge Ferrer, Juan Valcárcel, Manuel Irimia
Published in: Nature Metabolism, Issue 5, 2023, Page(s) 219–236, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-022-00734-2

<scp>ARC</scp> Expands the <scp>DAAM1</scp> Microexon‐Mediated Actin– <scp>RHOA</scp> / <scp>ROCK</scp> Interplay

Author(s): Patryk Poliński, Marta Miret Cuesta, Manuel Irimia
Published in: Cytoskeleton, Issue 83, 2026, Page(s) 123-127, ISSN 1949-3584
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/cm.22051

Gene Duplication and Alternative Splicing as Evolutionary Drivers of Proteome Specialization

Author(s): Federica Mantica, Manuel Irimia
Published in: BioEssays, Issue 47, 2025, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.202400202

Alternative splicing decouples local from global PRC2 activity

Author(s): Niccolò Arecco, Ivano Mocavini, Enrique Blanco, Cecilia Ballaré, Elina Libman, Sophie Bonnal, Manuel Irimia, Luciano Di Croce
Published in: Molecular Cell, Issue 84, 2025, Page(s) 1049-1061.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.02.011