A multimodal approach to tendon mechanobiology

Project Information

TENDON_MECHBIO

Grant agreement ID: 101002516

DOI

10.3030/101002516

EC signature date 30 March 2021

Start date 1 May 2021

End date 30 April 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 002 622,00

EU contribution

€ 2 002 622,00

Coordinated by

LUNDS UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management plan

Open Research Data dissemination of the main results and data produced by TENDONMECHBIO grant

Publications

Peer reviewed articles (13)

A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography

Author(s): E. Dall’Ara, A.J. Bodey, H. Isaksson, G. Tozzi
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105297

Spatiotemporal and microstructural characterization of heterotopic ossification in healing rat Achilles tendons

Author(s): Maria Pierantoni, Malin Hammerman, Isabella Silva Barreto, Daniel Larsson, Thomas Notermans, Andrew J. Bodey, Pernilla Eliasson, Hanna Isaksson
Published in: The FASEB Journal, Issue 37, 2023, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202201018rrr

Multimodal and Multiscale Characterization Reveals How Tendon Structure and Mechanical Response are Altered by Reduced Loading

Author(s): Maria Pierantoni; Isabella Silva Barreto; Malin Hammerman; Vladimir Novak; Ana Diaz; Jonas Engqvist; Pernilla Eliasson; Hanna Isaksson
Published in: Acta biomaterialia, Issue 3, 2023, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.2139/ssrn.4434706

Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons

Author(s): Isabella Silva Barreto; Maria Pierantoni; Malin Hammerman; Elin Törnquist; Sophie Le Cann; Ana Diaz; Jonas Engqvist; Marianne Liebi; Pernilla Eliasson; Hanna Isaksson
Published in: Matrix Biology, Issue 115, January 2023, 2022, Page(s) 32-47, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/j.matbio.2022.11.006

Quantification of 3D microstructures in Achilles tendons during in situ loading reveals anisotropic fiber response

Author(s): Maria Pierantoni, Kunal Sharma, Joeri Kok, Vladimir Novak, Pernilla Eliasson, Hanna Isaksson
Published in: Acta Biomaterialia, Issue 194, 2025, Page(s) 246-257, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.023

Micro- and nanostructure specific X-ray tomography reveals less matrix formation and altered collagen organization following reduced loading during Achilles tendon healing

Author(s): Isabella Silva Barreto; Maria Pierantoni; Leonard C. Nielsen; Malin Hammerman; Ana Diaz; Vladimir Novak; Pernilla Eliasson; Marianne Liebi; Hanna Isaksson
Published in: Acta Biomaterialia, Issue 174, 2024, Page(s) 245-257, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2023.12.015

Heterotopic ossification in intact rat Achilles tendons are characterized by a unique mineralized collagen fiber structure

Author(s): M. Pierantoni, L. Andersson, M. Hammerman, I. Silva Barreto, V. Novak, H. Isaksson, P. Eliasson
Published in: Journal of Structural Biology, 2023, Page(s) 100087, ISSN 2590-1524
Publisher: Elsevier Inc.
DOI: 10.1016/j.yjsbx.2023.100087

Deprivation of loading during rat Achilles tendon healing affects extracellular matrix composition and structure, and reduces cell density and alignment

Author(s): Malin Hammerman, Maria Pierantoni, Hanna Isaksson, Pernilla Eliasson
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-74783-w

Tendon mechanobiology in small animal experiments during post-transection healing

Author(s): T.M.W. Notermans, M. Hammerman, P. Eliasson, H. Isaksson
Published in: European Cell and Materials, Issue 14732262, 2021, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v042a23

Elemental and Structural Characterization of Heterotopic Ossification during Achilles Tendon Healing Provides New Insights on the Formation Process

Author(s): Kunal Sharma, Isabella Silva Barreto, Hector Dejea, Malin Hammerman, Christian Appel, Kalotina Geraki, Pernilla Eliasson, Maria Pierantoni, Hanna Isaksson
Published in: ACS Biomaterials Science & Engineering, Issue 10, 2024, Page(s) 4938-4946, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.4c00935

A numerical framework for mechano-regulated tendon repair – simulation of early healing of the Achilles tendon

Author(s): T.M.W. Notermans, P. Tanska, R.K. Korhonen, H. Khayyeri, H. Isaksson
Published in: PLOS Computational Biology, 2021, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1008636

Predicting the effect of reduced load level and cell infiltration on spatio-temporal Achilles tendon healing.

Author(s): Thomas Notermans; Hanifeh Khayyeri; Hanna Isaksson
Published in: Journal of Biomechanics, Issue 00219290, 2021, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110853

Predicting the formation of different tissue types during Achilles tendon healing using mechanoregulated and oxygen-regulated frameworks.

Author(s): Thomas Notermans; Hanna Isaksson
Published in: Biomech Model Mechanobiol, 2022, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-022-01672-4

Thesis and dissertations (2)

Synchrotron-based characterization of mechanobiological effects on the nanoscale in musculoskeletal tissues.

Author(s): Isabella Silva Barreto
Published in: 2023
Publisher: Lund University

Computational modeling of mechanobiology in intact and healing rat Achilles tendon

Author(s): Thomas Notermans
Published in: 2021
Publisher: Lund University