A multimodal approach to tendon mechanobiology

Información del proyecto

TENDON_MECHBIO

Identificador del acuerdo de subvención: 101002516

DOI

10.3030/101002516

Fecha de la firma de la CE 30 Marzo 2021

Fecha de inicio 1 Mayo 2021

Fecha de finalización 30 Abril 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 002 622,00

Aportación de la UE

€ 2 002 622,00

Coordinado por

LUNDS UNIVERSITET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management plan

Open Research Data dissemination of the main results and data produced by TENDONMECHBIO grant

Publicaciones

Peer reviewed articles (13)

A practical guide for in situ mechanical testing of musculoskeletal tissues using synchrotron tomography

Autores: E. Dall’Ara, A.J. Bodey, H. Isaksson, G. Tozzi
Publicado en: Journal of the Mechanical Behavior of Biomedical Materials, 2022, ISSN 1751-6161
Editor: Elsevier BV
DOI: 10.1016/j.jmbbm.2022.105297

Spatiotemporal and microstructural characterization of heterotopic ossification in healing rat Achilles tendons

Autores: Maria Pierantoni, Malin Hammerman, Isabella Silva Barreto, Daniel Larsson, Thomas Notermans, Andrew J. Bodey, Pernilla Eliasson, Hanna Isaksson
Publicado en: The FASEB Journal, Edición 37, 2023, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202201018rrr

Multimodal and Multiscale Characterization Reveals How Tendon Structure and Mechanical Response are Altered by Reduced Loading

Autores: Maria Pierantoni; Isabella Silva Barreto; Malin Hammerman; Vladimir Novak; Ana Diaz; Jonas Engqvist; Pernilla Eliasson; Hanna Isaksson
Publicado en: Acta biomaterialia, Edición 3, 2023, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.2139/ssrn.4434706

Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons

Autores: Isabella Silva Barreto; Maria Pierantoni; Malin Hammerman; Elin Törnquist; Sophie Le Cann; Ana Diaz; Jonas Engqvist; Marianne Liebi; Pernilla Eliasson; Hanna Isaksson
Publicado en: Matrix Biology, Edición 115, January 2023, 2022, Página(s) 32-47, ISSN 0945-053X
Editor: Elsevier BV
DOI: 10.1016/j.matbio.2022.11.006

Quantification of 3D microstructures in Achilles tendons during in situ loading reveals anisotropic fiber response

Autores: Maria Pierantoni, Kunal Sharma, Joeri Kok, Vladimir Novak, Pernilla Eliasson, Hanna Isaksson
Publicado en: Acta Biomaterialia, Edición 194, 2025, Página(s) 246-257, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.023

Micro- and nanostructure specific X-ray tomography reveals less matrix formation and altered collagen organization following reduced loading during Achilles tendon healing

Autores: Isabella Silva Barreto; Maria Pierantoni; Leonard C. Nielsen; Malin Hammerman; Ana Diaz; Vladimir Novak; Pernilla Eliasson; Marianne Liebi; Hanna Isaksson
Publicado en: Acta Biomaterialia, Edición 174, 2024, Página(s) 245-257, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2023.12.015

Heterotopic ossification in intact rat Achilles tendons are characterized by a unique mineralized collagen fiber structure

Autores: M. Pierantoni, L. Andersson, M. Hammerman, I. Silva Barreto, V. Novak, H. Isaksson, P. Eliasson
Publicado en: Journal of Structural Biology, 2023, Página(s) 100087, ISSN 2590-1524
Editor: Elsevier Inc.
DOI: 10.1016/j.yjsbx.2023.100087

Deprivation of loading during rat Achilles tendon healing affects extracellular matrix composition and structure, and reduces cell density and alignment

Autores: Malin Hammerman, Maria Pierantoni, Hanna Isaksson, Pernilla Eliasson
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-74783-w

Tendon mechanobiology in small animal experiments during post-transection healing

Autores: T.M.W. Notermans, M. Hammerman, P. Eliasson, H. Isaksson
Publicado en: European Cell and Materials, Edición 14732262, 2021, ISSN 1473-2262
Editor: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v042a23

Elemental and Structural Characterization of Heterotopic Ossification during Achilles Tendon Healing Provides New Insights on the Formation Process

Autores: Kunal Sharma, Isabella Silva Barreto, Hector Dejea, Malin Hammerman, Christian Appel, Kalotina Geraki, Pernilla Eliasson, Maria Pierantoni, Hanna Isaksson
Publicado en: ACS Biomaterials Science & Engineering, Edición 10, 2024, Página(s) 4938-4946, ISSN 2373-9878
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.4c00935

A numerical framework for mechano-regulated tendon repair – simulation of early healing of the Achilles tendon

Autores: T.M.W. Notermans, P. Tanska, R.K. Korhonen, H. Khayyeri, H. Isaksson
Publicado en: PLOS Computational Biology, 2021, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1008636

Predicting the effect of reduced load level and cell infiltration on spatio-temporal Achilles tendon healing.

Autores: Thomas Notermans; Hanifeh Khayyeri; Hanna Isaksson
Publicado en: Journal of Biomechanics, Edición 00219290, 2021, ISSN 0021-9290
Editor: Elsevier BV
DOI: 10.1016/j.jbiomech.2021.110853

Predicting the formation of different tissue types during Achilles tendon healing using mechanoregulated and oxygen-regulated frameworks.

Autores: Thomas Notermans; Hanna Isaksson
Publicado en: Biomech Model Mechanobiol, 2022, ISSN 1617-7959
Editor: Springer Verlag
DOI: 10.1007/s10237-022-01672-4

Thesis and dissertations (2)

Synchrotron-based characterization of mechanobiological effects on the nanoscale in musculoskeletal tissues.

Autores: Isabella Silva Barreto
Publicado en: 2023
Editor: Lund University

Computational modeling of mechanobiology in intact and healing rat Achilles tendon

Autores: Thomas Notermans
Publicado en: 2021
Editor: Lund University