REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeutics

Project Information

RESPIRNA

Grant agreement ID: 101002571

DOI

10.3030/101002571

EC signature date 26 February 2021

Start date 1 May 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 985 828,00

EU contribution

€ 1 985 828,00

Coordinated by

UNIVERSITEIT GENT
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action

Author(s): Roberta Guagliardo, Lore Herman, Jelle Penders, Agata Zamborlin, Herlinde De Keersmaecker, Thijs Van de Vyver, Sandrine Verstraeten, Pieterjan Merckx, Marie-Paule Mingeot-Leclercq, Mercedes Echaide, Jesús Pérez-Gil, Molly M Stevens, Stefaan C De Smedt, Koen Raemdonck
Published in: ACS Nano, 2021, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.0c04489

Pulmonary surfactant as a versatile biomaterial to fight COVID-19.

Author(s): Lore Herman; Stefaan C. De Smedt; Koen Raemdonck
Published in: Journal of Controlled Release, 2022, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.11.023

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Author(s): Bram Bogaert; Félix Sauvage; Roberta Guagliardo; Cristina Muntean; Van Phuc Nguyen; Eline Pottie; Mike Wels; An-Katrien Minnaert; Riet De Rycke; Qiangbing Yang; Dan Peer; Niek Sanders; Katrien Remaut; Yannis M. Paulus; Christophe Stove; Stefaan C. De Smedt; Koen Raemdonck
Published in: Journal of Controlled Release, Issue 1, 2022, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.08.009

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Author(s): Pieterjan Merckx, Griet Conickx, Evy Blomme, Tania Maes, Ken R. Bracke, Guy Brusselle, Stefaan C. De Smedt, Koen Raemdonck
Published in: European Journal of Pharmaceutics and Biopharmaceutics, 2024, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2024.114223

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

Author(s): Thijs Van de Vyver; Stefaan C. De Smedt; Koen Raemdonck
Published in: Advanced Drug Delivery Reviews, Issue 1, 2022, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.114041

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Author(s): Bram Bogaert, Aliona Debisschop, Thomas Ehouarne, Hannelore P Van Eeckhoutte, Joyceline De Volder, An Jacobs, Eline Pottie, Riet De Rycke, Aurélie Crabbé, Pieter Mestdagh, Ine Lentacker, Guy G Brusselle, Christophe Stove, Sandra Verstraelen, Tania Maes, Ken R Bracke, Stefaan C De Smedt, Koen Raemdonck
Published in: Nano Letters, 2024, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.3c03345

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Author(s): Thijs Van de Vyver, Cristina Muntean, Iuliia Efimova, Dmitri V. Krysko, Lynn De Backer, Stefaan De Smedt and Koen Raemdonck
Published in: Journal of Controlled Release, 2023, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.10.014

Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer

Author(s): Cristina Muntean; Eva Blondeel; Laure Harinck; Kunal Pednekar; Jai Prakash; Olivier De Wever; Jeanne Leblond Chain; Stefaan C. De Smedt; Katrien Remaut; Koen Raemdonck
Published in: International Journal of Pharmaceutics, Issue 1, 2023, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123348

Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Author(s): Elnaz Shaabani, Maryam Sharifiaghdam, Joris Lammens, Herlinde De Keersmaecker, Chris Vervaet, Thomas De Beer, Elahe Motevaseli, Mohammad Hossein Ghahremani, Parvin Mansouri, Stefaan De Smedt, Koen Raemdonck, Reza Faridi-Majidi, Kevin Braeckmans, Juan C Fraire
Published in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179216