REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeutics

Informazioni relative al progetto

RESPIRNA

ID dell’accordo di sovvenzione: 101002571

DOI

10.3030/101002571

Progetto chiuso

Data della firma CE 26 Febbraio 2021

Data di avvio 1 Maggio 2021

Data di completamento 30 Aprile 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 985 828,00

Contributo UE

€ 1 985 828,00

Coordinato da

UNIVERSITEIT GENT
Belgium

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (12)

Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action

Autori: Roberta Guagliardo, Lore Herman, Jelle Penders, Agata Zamborlin, Herlinde De Keersmaecker, Thijs Van de Vyver, Sandrine Verstraeten, Pieterjan Merckx, Marie-Paule Mingeot-Leclercq, Mercedes Echaide, Jesús Pérez-Gil, Molly M Stevens, Stefaan C De Smedt, Koen Raemdonck
Pubblicato in: ACS Nano, 2021, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.0c04489

Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR‐T Cell Engineering

Autori: Laure Harinck, Stijn De Munter, Margo De Velder, Joline Ingels, Dominika Berdecka, Ine Lentacker, Winnok H. De Vos, Bart Vandekerckhove, Kevin Braeckmans, Koen Raemdonck
Pubblicato in: Advanced Science, Numero 13, 2026, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202521507

Pulmonary surfactant as a versatile biomaterial to fight COVID-19.

Autori: Lore Herman; Stefaan C. De Smedt; Koen Raemdonck
Pubblicato in: Journal of Controlled Release, 2022, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2021.11.023

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Autori: Bram Bogaert; Félix Sauvage; Roberta Guagliardo; Cristina Muntean; Van Phuc Nguyen; Eline Pottie; Mike Wels; An-Katrien Minnaert; Riet De Rycke; Qiangbing Yang; Dan Peer; Niek Sanders; Katrien Remaut; Yannis M. Paulus; Christophe Stove; Stefaan C. De Smedt; Koen Raemdonck
Pubblicato in: Journal of Controlled Release, Numero 1, 2022, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2022.08.009

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Autori: Pieterjan Merckx, Griet Conickx, Evy Blomme, Tania Maes, Ken R. Bracke, Guy Brusselle, Stefaan C. De Smedt, Koen Raemdonck
Pubblicato in: European Journal of Pharmaceutics and Biopharmaceutics, 2024, ISSN 0939-6411
Editore: Elsevier BV
DOI: 10.1016/j.ejpb.2024.114223

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

Autori: Thijs Van de Vyver; Stefaan C. De Smedt; Koen Raemdonck
Pubblicato in: Advanced Drug Delivery Reviews, Numero 1, 2022, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2021.114041

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Autori: Bram Bogaert, Aliona Debisschop, Thomas Ehouarne, Hannelore P Van Eeckhoutte, Joyceline De Volder, An Jacobs, Eline Pottie, Riet De Rycke, Aurélie Crabbé, Pieter Mestdagh, Ine Lentacker, Guy G Brusselle, Christophe Stove, Sandra Verstraelen, Tania Maes, Ken R Bracke, Stefaan C De Smedt, Koen Raemdonck
Pubblicato in: Nano Letters, 2024, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.3c03345

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Autori: Thijs Van de Vyver, Cristina Muntean, Iuliia Efimova, Dmitri V. Krysko, Lynn De Backer, Stefaan De Smedt and Koen Raemdonck
Pubblicato in: Journal of Controlled Release, 2023, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2023.10.014

Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer

Autori: Cristina Muntean; Eva Blondeel; Laure Harinck; Kunal Pednekar; Jai Prakash; Olivier De Wever; Jeanne Leblond Chain; Stefaan C. De Smedt; Katrien Remaut; Koen Raemdonck
Pubblicato in: International Journal of Pharmaceutics, Numero 1, 2023, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.123348

Beyond chloroquine: Cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics

Autori: Aliona Debisschop, Bram Bogaert, Cristina Muntean, Stefaan C. De Smedt, Koen Raemdonck
Pubblicato in: Current Opinion in Chemical Biology, Numero 83, 2024, Pagina/e 102531, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2024.102531

Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA

Autori: Lore Herman, Roberta Guagliardo, Agata Zamborlin, Qiaoyu Liu, Jesús Pérez-Gil, Stefaan C. De Smedt, Koen Raemdonck
Pubblicato in: Journal of Controlled Release, Numero 381, 2026, Pagina/e 113571, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2025.02.067

Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Autori: Elnaz Shaabani, Maryam Sharifiaghdam, Joris Lammens, Herlinde De Keersmaecker, Chris Vervaet, Thomas De Beer, Elahe Motevaseli, Mohammad Hossein Ghahremani, Parvin Mansouri, Stefaan De Smedt, Koen Raemdonck, Reza Faridi-Majidi, Kevin Braeckmans, Juan C Fraire
Pubblicato in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179216