Organic phases in cells: Elucidating the physical nature of biological liquid droplets

Project Information

BlobMech

Grant agreement ID: 101002859

DOI

10.3030/101002859

EC signature date 13 April 2021

Start date 1 September 2021

End date 31 August 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 806,00

EU contribution

€ 1 999 806,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Posttranslational, site-directed photochemical fluorine editing of protein sidechains to probe residue oxidation state via 19F-nuclear magnetic resonance

Author(s): Patrick G. Isenegger, Brian Josephson, Ben Gaunt, Matthew J. Davy, Veronique Gouverneur, Andrew J. Baldwin, Benjamin G. Davis
Published in: Nature Protocols, Issue 18, 2023, Page(s) 1543-1562, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-022-00800-9

Uncovering the Role of <i>N</i>-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

Author(s): El-Baba, TJ; Lutomski, CA; Burnap, SA; Bolla, JR; Baker, LA; Baldwin, AJ; Struwe, WB; Robinson, CV
Published in: Crossref, Issue 2, 2023, ISSN 1520-5126
Publisher: ACS Publications
DOI: 10.1021/jacs.3c00291

UnidecNMR: automatic peak detection for NMR spectra in 1-4 dimensions

Author(s): Charles Buchanan, Gogulan Karunanithy, Olga Tkachenko, Michael Barber, Michael T. Marty, Timothy J. Nott, Christina Redfield, Andrew J. Baldwin
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54899-3

Reductive site-selective atypical <i>C</i> , <i>Z</i> -type/N2-C2 cleavage allows C-terminal protein amidation

Author(s): Mollner, TA; Giltrap, AM; Zeng, Y; Demyanenko, Y; Buchanan, C; Oehlrich, D; Baldwin, AJ; Anthony, DC; Mohammed, S; Davis, BG
Published in: Crossref, Issue 4, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abl8675

Small-molecule dissolution of stress granules by redox modulation benefits ALS models

Author(s): Hiroyuki Uechi, Sindhuja Sridharan, Jik Nijssen, Jessica Bilstein, Juan M. Iglesias-Artola, Satoshi Kishigami, Virginia Casablancas-Antras, Ina Poser, Eduardo J. Martinez, Edgar Boczek, Michael Wagner, Nadine Tomschke, António M. de Jesus Domingues, Arun Pal, Thom Doeleman, Sukhleen Kour, Eric Nathaniel Anderson, Frank Stein, Hyun O. Lee, Xiaojie Zhang, Anatol W. Fritsch, Marcus Jahnel, Julius F
Published in: Nature Chemical Biology, Issue 21, 2025, Page(s) 1577-1588, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-025-01893-5

Efficiently computing the Uhlmann fidelity for density matrices

Author(s): Andrew J. Baldwin; Jonathan A. Jones
Published in: Crossref, Issue 1, 2023, ISSN 2469-9926
Publisher: American Physical Society
DOI: 10.1103/physreva.107.012427

Poststranlational, site-directed photochemical fluorine editing of protein sidechains to probe residue oxidation state via 19F-nuclear magnetic resonance

Author(s): Isenegger, Patrick G; Josephson, Brian; Gaunt, Ben; Davy, Matthew J; Gouverneur, Veronique; Baldwin, Andrew J; Davis, Benjamin G.
Published in: natureprotocols, 2023, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2733-7

Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions

Author(s): Crabtree MD, Hollan J, Pillai AS, Kompella PS, Babl Leon, Turner Noah, Eaton James, Hochberg GKA, Aarts Dirk, Redfield Christina, Baldwin AJ, Nott Timothy
Published in: Cell Reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113375

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Author(s): Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyanenko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51138-7

Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR

Author(s): Rowbotham, JS; Nicholson, JH; Ramirez, MA; Urata, K; Todd, PMT; Karunanithy, G; Lauterbach, L; Reeve, HA; Baldwin, AJ; Vincent, KA
Published in: Rowbotham , J , Nicholson , J , Hernandez , M R , Urata , K , Todd , P M T , Karunanithy , G , Lauterbach , L , Reeve , H , Baldwin , A & Vincent , K 2023 , ' Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR ' , Chemical Science , vol. 14 , no. 43 , pp. 12160-12165 . https://doi.org/10.1039/d3sc01718d, Issue 2, 2023, ISSN 2041-6539
Publisher: RWTH Publications
DOI: 10.1039/d3sc01718d

Seedless: on-the-fly pulse calculation for NMR experiments

Author(s): Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones, Andrew J. Baldwin
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-61663-8

Pathogen-sugar interactions revealed by universal saturation transfer analysis

Author(s): Charles Buchanan, Ben Gaunt, Peter Harrison, Yun Yang, Jiwei Liu, Aziz Khan, Andrew Giltrap, Audrey Le Bas, Philipp Ward, Kapil Gupta, Maud Dumoux, Tiong Kit Tan, Lisa Schimaski, Sergio Daga, Picchiotti Nicola, Margherita Baldassarri, Elisa Benetti, Chiara Fallerini, Francesca Fava, Annarita Giliberti, Panagiotis Koukos, Matthew Davy, Abirami Lakshminarayanan, Xiaochao Xue, Georgios Papadakis, Lac
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abm3125

Thesis and dissertations (1)

Mechanistic insights on protein aggregation and phase separation

Author(s): Casablancas Antràs, V
Published in: Thesis, Issue 1, 2023, Page(s) All
Publisher: University of Oxford
DOI: 10.5287/ora-qq77bd2gy