Organic phases in cells: Elucidating the physical nature of biological liquid droplets

Informazioni relative al progetto

BlobMech

ID dell’accordo di sovvenzione: 101002859

DOI

10.3030/101002859

Data della firma CE 13 Aprile 2021

Data di avvio 1 Settembre 2021

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 806,00

Contributo UE

€ 1 999 806,00

Coordinato da

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (12)

Posttranslational, site-directed photochemical fluorine editing of protein sidechains to probe residue oxidation state via 19F-nuclear magnetic resonance

Autori: Patrick G. Isenegger, Brian Josephson, Ben Gaunt, Matthew J. Davy, Veronique Gouverneur, Andrew J. Baldwin, Benjamin G. Davis
Pubblicato in: Nature Protocols, Numero 18, 2023, Pagina/e 1543-1562, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41596-022-00800-9

Uncovering the Role of <i>N</i>-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

Autori: El-Baba, TJ; Lutomski, CA; Burnap, SA; Bolla, JR; Baker, LA; Baldwin, AJ; Struwe, WB; Robinson, CV
Pubblicato in: Crossref, Numero 2, 2023, ISSN 1520-5126
Editore: ACS Publications
DOI: 10.1021/jacs.3c00291

UnidecNMR: automatic peak detection for NMR spectra in 1-4 dimensions

Autori: Charles Buchanan, Gogulan Karunanithy, Olga Tkachenko, Michael Barber, Michael T. Marty, Timothy J. Nott, Christina Redfield, Andrew J. Baldwin
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-54899-3

Reductive site-selective atypical <i>C</i> , <i>Z</i> -type/N2-C2 cleavage allows C-terminal protein amidation

Autori: Mollner, TA; Giltrap, AM; Zeng, Y; Demyanenko, Y; Buchanan, C; Oehlrich, D; Baldwin, AJ; Anthony, DC; Mohammed, S; Davis, BG
Pubblicato in: Crossref, Numero 4, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abl8675

Small-molecule dissolution of stress granules by redox modulation benefits ALS models

Autori: Hiroyuki Uechi, Sindhuja Sridharan, Jik Nijssen, Jessica Bilstein, Juan M. Iglesias-Artola, Satoshi Kishigami, Virginia Casablancas-Antras, Ina Poser, Eduardo J. Martinez, Edgar Boczek, Michael Wagner, Nadine Tomschke, António M. de Jesus Domingues, Arun Pal, Thom Doeleman, Sukhleen Kour, Eric Nathaniel Anderson, Frank Stein, Hyun O. Lee, Xiaojie Zhang, Anatol W. Fritsch, Marcus Jahnel, Julius F
Pubblicato in: Nature Chemical Biology, Numero 21, 2025, Pagina/e 1577-1588, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-025-01893-5

Efficiently computing the Uhlmann fidelity for density matrices

Autori: Andrew J. Baldwin; Jonathan A. Jones
Pubblicato in: Crossref, Numero 1, 2023, ISSN 2469-9926
Editore: American Physical Society
DOI: 10.1103/physreva.107.012427

Poststranlational, site-directed photochemical fluorine editing of protein sidechains to probe residue oxidation state via 19F-nuclear magnetic resonance

Autori: Isenegger, Patrick G; Josephson, Brian; Gaunt, Ben; Davy, Matthew J; Gouverneur, Veronique; Baldwin, Andrew J; Davis, Benjamin G.
Pubblicato in: natureprotocols, 2023, ISSN 1754-2189
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2733-7

Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions

Autori: Crabtree MD, Hollan J, Pillai AS, Kompella PS, Babl Leon, Turner Noah, Eaton James, Hochberg GKA, Aarts Dirk, Redfield Christina, Baldwin AJ, Nott Timothy
Pubblicato in: Cell Reports, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.113375

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Autori: Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyanenko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51138-7

Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR

Autori: Rowbotham, JS; Nicholson, JH; Ramirez, MA; Urata, K; Todd, PMT; Karunanithy, G; Lauterbach, L; Reeve, HA; Baldwin, AJ; Vincent, KA
Pubblicato in: Rowbotham , J , Nicholson , J , Hernandez , M R , Urata , K , Todd , P M T , Karunanithy , G , Lauterbach , L , Reeve , H , Baldwin , A & Vincent , K 2023 , ' Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR ' , Chemical Science , vol. 14 , no. 43 , pp. 12160-12165 . https://doi.org/10.1039/d3sc01718d, Numero 2, 2023, ISSN 2041-6539
Editore: RWTH Publications
DOI: 10.1039/d3sc01718d

Seedless: on-the-fly pulse calculation for NMR experiments

Autori: Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones, Andrew J. Baldwin
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-61663-8

Pathogen-sugar interactions revealed by universal saturation transfer analysis

Autori: Charles Buchanan, Ben Gaunt, Peter Harrison, Yun Yang, Jiwei Liu, Aziz Khan, Andrew Giltrap, Audrey Le Bas, Philipp Ward, Kapil Gupta, Maud Dumoux, Tiong Kit Tan, Lisa Schimaski, Sergio Daga, Picchiotti Nicola, Margherita Baldassarri, Elisa Benetti, Chiara Fallerini, Francesca Fava, Annarita Giliberti, Panagiotis Koukos, Matthew Davy, Abirami Lakshminarayanan, Xiaochao Xue, Georgios Papadakis, Lac
Pubblicato in: Science, 2022, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abm3125

Thesis and dissertations (1)

Mechanistic insights on protein aggregation and phase separation

Autori: Casablancas Antràs, V
Pubblicato in: Thesis, Numero 1, 2023, Pagina/e All
Editore: University of Oxford
DOI: 10.5287/ora-qq77bd2gy