Challenging current models of valence encoding in the mammalian brain

Información del proyecto

VALENCE

Identificador del acuerdo de subvención: 101003187

DOI

10.3030/101003187

Fecha de la firma de la CE 4 Febrero 2021

Fecha de inicio 1 Mayo 2021

Fecha de finalización 30 Abril 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 988 266,00

Aportación de la UE

€ 1 988 266,00

Coordinado por

UNIVERSIDADE DO MINHO
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan of project VALENCE

Publicaciones

Peer reviewed articles (19)

Chronic stress and cytogenesis ablation disrupt hippocampal neuron connectivity, with fluoxetine restoring function with sex-specific effects

Autores: Inês Ribeiro, Tiago Silveira-Rosa, Joana Martins-Macedo, Luísa Marques-Ferraz, Ana Rita Dourado, Gonçalo Martins-Ferreira, Fanny Farrugia, Ana João Rodrigues, Djoher Nora Abrous, Nuno Dinis Alves,
Publicado en: Neurobiology of Stress, Edición 37, 2025, Página(s) 100743, ISSN 2352-2895
Editor: Elsevier BV
DOI: 10.1016/j.ynstr.2025.100743

Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure

Autores: Machado-Santos et al
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: Wiley
DOI: 10.3390/cells11030390

Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

Autores: Loureiro-Campos et al
Publicado en: eLife, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.70685.sa0

Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Autores: Soares-Cunha et al
Publicado en: Cell Reports, Edición 22111247, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.110380

Early life behavioral deficits and microglia remodeling in the mesocorticolimbic system precede the emergence of Schizophrenia-like symptoms

Autores: Ana C. Rodrigues-Neves, Jéssica Monteiro, Bárbara Coimbra, Rita Gaspar, Verónica Domingues, Carina Soares-Cunha, Patrícia Patrício, Marta I. Pereira, Ana L. Cardoso, Luísa Pinto, João Bessa, An
Publicado en: Brain, Behavior, and Immunity, Edición 129, 2025, Página(s) 416-433, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2025.06.009

Cell Cycle Regulation of Hippocampal Progenitor Cells in Experimental Models of Depression and after Treatment with Fluoxetine

Autores: Patricio et al
Publicado en: Int J Mol Sci, Edición 14220067, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111798

Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity

Autores: Tiago Silveira-Rosa, António Mateus-Pinheiro, Joana Sofia Correia, Joana Margarida Silva, Joana Martins-Macedo, Bruna Araújo, Ana Rita Machado-Santos, Nuno Dinis Alves, Mariana Silva, Eduardo Loureiro-Campos, Ioannis Sotiropoulos, João Miguel Bessa, Ana João Rodrigues, Nuno Sousa, Patrícia Patrício, Luísa Pinto
Publicado en: Cell proliferation, 2022, ISSN 0960-7722
Editor: Blackwell Publishing Inc.
DOI: 10.1111/cpr.13165

Involvement of nucleus accumbens D2–medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour

Autores: Raquel Correia, Bárbara Coimbra, Ana Verónica Domingues, Marcelina Wezik, Natacha Vieitas-Gaspar, Rita Gaspar, Nuno Sousa, Luísa Pinto, Ana João Rodrigues and Carina Soares-Cunha
Publicado en: J Psychiatry Neurosci, 2023, ISSN 1180-4882
Editor: Canadian Medical Association/Association Medical Canadienne
DOI: 10.1503/jpn.220111

Dopamine in the nucleus accumbens in valence-based learning: is it really important?

Autores: Ana João Rodrigues
Publicado en: Current Opinion in Behavioral Sciences, Edición 61, 2025, Página(s) 101462, ISSN 2352-1546
Editor: Elsevier Limited
DOI: 10.1016/j.cobeha.2024.101462

Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation

Autores: Joana Martins-Macedo, Bruna Araújo, Sandra I. Anjo, Tiago Silveira-Rosa, Patrícia Patrício, Nuno Dinis Alves, Joana M. Silva, Fábio G. Teixeira, Bruno Manadas, Ana J. Rodrigues, Angelo C. Lepore,
Publicado en: Molecular Psychiatry, Edición 29, 2024, Página(s) 2185-2198, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-024-02490-z

From valence encoding to motivated behavior: A focus on the nucleus accumbens circuitry

Autores: Natacha Vieitas-Gaspar, Carina Soares-Cunha, Ana João Rodrigues
Publicado en: Neuroscience & Biobehavioral Reviews, Edición 172, 2025, Página(s) 106125, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2025.106125

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

Autores: Gaspar et al
Publicado en: Front. Behav. Neurosci, Edición 16625153, 2022, ISSN 1662-5153
Editor: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.834821

StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats

Autores: Martins-Macedo et al.
Publicado en: Cells, 2023, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12030381

Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Autores: Deseyve et al
Publicado en: Journal of Neurochemistry, 2024, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16063

Fabrication, Electrochemical Characterization, and In Vivo Validation of a Flexible Neural Probe

Autores: João R. Freitas, José A. Rodrigues, João L. Machado, Leandro A. A. Aguiar, Ana J. Rodrigues, João F. Oliveira, José H. Correia, Sara Pimenta
Publicado en: Journal of Microelectromechanical Systems, Edición 34, 2025, Página(s) 482-487, ISSN 1057-7157
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jmems.2025.3579544

The mesopontine tegmentum in reward and aversion: From cellular heterogeneity to behaviour

Autores: Ricardo Bastos-Gonçalves, Bárbara Coimbra, Ana João Rodrigues
Publicado en: Neuroscience & Biobehavioral Reviews, Edición 162, 2024, Página(s) 105702, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105702

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

Autores: Ana Verónica Domingues, Tawan T. A. Carvalho, Gabriela J. Martins, Raquel Correia, Bárbara Coimbra, Ricardo Bastos-Gonçalves, Marcelina Wezik, Rita Gaspar, Luísa Pinto, Nuno Sousa, Rui M. Costa, C
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-55269-9

In and Out of Criticality? State-Dependent Scaling in the Rat Visual Cortex

Autores: Daniel M. Castro, Thaís Feliciano, Nivaldo A. P. de Vasconcelos, Carina Soares-Cunha, Bárbara Coimbra, Ana João Rodrigues, Pedro V. Carelli, Mauro Copelli
Publicado en: PRX Life, Edición 2, 2024, ISSN 2835-8279
Editor: American Physical Society (APS)
DOI: 10.1103/prxlife.2.023008

Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rats

Autores: Domingues et al
Publicado en: Translational Psychiatry, Edición 21583188, 2022, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-022-02043-4

Non-peer reviewed articles (1)

State-dependent complexity of the local field potential in the primary visual cortex

Autores: Rafael M. Jungmann, Thaís Feliciano, Leandro A. A. Aguiar, Carina Soares-Cunha, Bárbara Coimbra, Ana João Rodrigues, Mauro Copelli, Fernanda S. Matias, Nivaldo A. P. de Vasconcelos, Pedro V. Carell
Publicado en: Physical Review E, Edición 110, 2024, ISSN 2470-0045
Editor: American Physical Society (APS)
DOI: 10.1103/physreve.110.014402