Challenging current models of valence encoding in the mammalian brain

Project Information

VALENCE

Grant agreement ID: 101003187

DOI

10.3030/101003187

EC signature date 4 February 2021

Start date 1 May 2021

End date 30 April 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 988 266,00

EU contribution

€ 1 988 266,00

Coordinated by

UNIVERSIDADE DO MINHO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan of project VALENCE

Publications

Peer reviewed articles (19)

Chronic stress and cytogenesis ablation disrupt hippocampal neuron connectivity, with fluoxetine restoring function with sex-specific effects

Author(s): Inês Ribeiro, Tiago Silveira-Rosa, Joana Martins-Macedo, Luísa Marques-Ferraz, Ana Rita Dourado, Gonçalo Martins-Ferreira, Fanny Farrugia, Ana João Rodrigues, Djoher Nora Abrous, Nuno Dinis Alves,
Published in: Neurobiology of Stress, Issue 37, 2025, Page(s) 100743, ISSN 2352-2895
Publisher: Elsevier BV
DOI: 10.1016/j.ynstr.2025.100743

Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure

Author(s): Machado-Santos et al
Published in: Cells, 2022, ISSN 2073-4409
Publisher: Wiley
DOI: 10.3390/cells11030390

Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

Author(s): Loureiro-Campos et al
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.70685.sa0

Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Author(s): Soares-Cunha et al
Published in: Cell Reports, Issue 22111247, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110380

Early life behavioral deficits and microglia remodeling in the mesocorticolimbic system precede the emergence of Schizophrenia-like symptoms

Author(s): Ana C. Rodrigues-Neves, Jéssica Monteiro, Bárbara Coimbra, Rita Gaspar, Verónica Domingues, Carina Soares-Cunha, Patrícia Patrício, Marta I. Pereira, Ana L. Cardoso, Luísa Pinto, João Bessa, An
Published in: Brain, Behavior, and Immunity, Issue 129, 2025, Page(s) 416-433, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2025.06.009

Cell Cycle Regulation of Hippocampal Progenitor Cells in Experimental Models of Depression and after Treatment with Fluoxetine

Author(s): Patricio et al
Published in: Int J Mol Sci, Issue 14220067, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111798

Suppression of adult cytogenesis in the rat brain leads to sex-differentiated disruption of the HPA axis activity

Author(s): Tiago Silveira-Rosa, António Mateus-Pinheiro, Joana Sofia Correia, Joana Margarida Silva, Joana Martins-Macedo, Bruna Araújo, Ana Rita Machado-Santos, Nuno Dinis Alves, Mariana Silva, Eduardo Loureiro-Campos, Ioannis Sotiropoulos, João Miguel Bessa, Ana João Rodrigues, Nuno Sousa, Patrícia Patrício, Luísa Pinto
Published in: Cell proliferation, 2022, ISSN 0960-7722
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cpr.13165

Involvement of nucleus accumbens D2–medium spiny neurons projecting to the ventral pallidum in anxiety-like behaviour

Author(s): Raquel Correia, Bárbara Coimbra, Ana Verónica Domingues, Marcelina Wezik, Natacha Vieitas-Gaspar, Rita Gaspar, Nuno Sousa, Luísa Pinto, Ana João Rodrigues and Carina Soares-Cunha
Published in: J Psychiatry Neurosci, 2023, ISSN 1180-4882
Publisher: Canadian Medical Association/Association Medical Canadienne
DOI: 10.1503/jpn.220111

Dopamine in the nucleus accumbens in valence-based learning: is it really important?

Author(s): Ana João Rodrigues
Published in: Current Opinion in Behavioral Sciences, Issue 61, 2025, Page(s) 101462, ISSN 2352-1546
Publisher: Elsevier Limited
DOI: 10.1016/j.cobeha.2024.101462

Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation

Author(s): Joana Martins-Macedo, Bruna Araújo, Sandra I. Anjo, Tiago Silveira-Rosa, Patrícia Patrício, Nuno Dinis Alves, Joana M. Silva, Fábio G. Teixeira, Bruno Manadas, Ana J. Rodrigues, Angelo C. Lepore,
Published in: Molecular Psychiatry, Issue 29, 2024, Page(s) 2185-2198, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02490-z

From valence encoding to motivated behavior: A focus on the nucleus accumbens circuitry

Author(s): Natacha Vieitas-Gaspar, Carina Soares-Cunha, Ana João Rodrigues
Published in: Neuroscience & Biobehavioral Reviews, Issue 172, 2025, Page(s) 106125, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2025.106125

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

Author(s): Gaspar et al
Published in: Front. Behav. Neurosci, Issue 16625153, 2022, ISSN 1662-5153
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2022.834821

StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats

Author(s): Martins-Macedo et al.
Published in: Cells, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12030381

Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Author(s): Deseyve et al
Published in: Journal of Neurochemistry, 2024, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.16063

Fabrication, Electrochemical Characterization, and In Vivo Validation of a Flexible Neural Probe

Author(s): João R. Freitas, José A. Rodrigues, João L. Machado, Leandro A. A. Aguiar, Ana J. Rodrigues, João F. Oliveira, José H. Correia, Sara Pimenta
Published in: Journal of Microelectromechanical Systems, Issue 34, 2025, Page(s) 482-487, ISSN 1057-7157
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jmems.2025.3579544

The mesopontine tegmentum in reward and aversion: From cellular heterogeneity to behaviour

Author(s): Ricardo Bastos-Gonçalves, Bárbara Coimbra, Ana João Rodrigues
Published in: Neuroscience & Biobehavioral Reviews, Issue 162, 2024, Page(s) 105702, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2024.105702

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

Author(s): Ana Verónica Domingues, Tawan T. A. Carvalho, Gabriela J. Martins, Raquel Correia, Bárbara Coimbra, Ricardo Bastos-Gonçalves, Marcelina Wezik, Rita Gaspar, Luísa Pinto, Nuno Sousa, Rui M. Costa, C
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-55269-9

In and Out of Criticality? State-Dependent Scaling in the Rat Visual Cortex

Author(s): Daniel M. Castro, Thaís Feliciano, Nivaldo A. P. de Vasconcelos, Carina Soares-Cunha, Bárbara Coimbra, Ana João Rodrigues, Pedro V. Carelli, Mauro Copelli
Published in: PRX Life, Issue 2, 2024, ISSN 2835-8279
Publisher: American Physical Society (APS)
DOI: 10.1103/prxlife.2.023008

Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rats

Author(s): Domingues et al
Published in: Translational Psychiatry, Issue 21583188, 2022, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-022-02043-4

Non-peer reviewed articles (1)

State-dependent complexity of the local field potential in the primary visual cortex

Author(s): Rafael M. Jungmann, Thaís Feliciano, Leandro A. A. Aguiar, Carina Soares-Cunha, Bárbara Coimbra, Ana João Rodrigues, Mauro Copelli, Fernanda S. Matias, Nivaldo A. P. de Vasconcelos, Pedro V. Carell
Published in: Physical Review E, Issue 110, 2024, ISSN 2470-0045
Publisher: American Physical Society (APS)
DOI: 10.1103/physreve.110.014402