Project description
Searching for new treatments for Acinetobacter baumannii infection
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterial pathogen associated with hospital infections including pneumonia, meningitis and bloodstream and wound infections. The recent increase in incidence coupled with a dramatic increase in cases associated with multidrug-resistant strains has attracted significant attention to this emerging deadly pathogen. The EU-funded AgainstResistance project proposes to find novel antimicrobial targets for A. baumannii using haem-related systems to be discovered by the researchers that help bacteria to utilise iron, contributing to pathogen survival. The research will employ bioinformatics as a tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be evaluated using microbiology and biochemistry, and their contribution to infection will be tested in host–pathogen interaction assays.
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Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinator
1099 085 Lisboa
Portugal
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