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Novel Strategy to cope with Multidrug Resistant Pathogens

Project description

Searching for new treatments for Acinetobacter baumannii infection

Acinetobacter baumannii (A. baumannii) is an opportunistic bacterial pathogen associated with hospital infections including pneumonia, meningitis and bloodstream and wound infections. The recent increase in incidence coupled with a dramatic increase in cases associated with multidrug-resistant strains has attracted significant attention to this emerging deadly pathogen. The EU-funded AgainstResistance project proposes to find novel antimicrobial targets for A. baumannii using haem-related systems to be discovered by the researchers that help bacteria to utilise iron, contributing to pathogen survival. The research will employ bioinformatics as a tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be evaluated using microbiology and biochemistry, and their contribution to infection will be tested in host–pathogen interaction assays.

Call for proposal

H2020-WF-2018-2020

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Sub call

H2020-WF-02-2019

Coordinator

UNIVERSIDADE NOVA DE LISBOA
Net EU contribution
€ 147 815,04
Address
Campus De Campolide
1099 085 Lisboa
Portugal

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00