Project description
Searching for new treatments for Acinetobacter baumannii infection
Acinetobacter baumannii (A. baumannii) is an opportunistic bacterial pathogen associated with hospital infections including pneumonia, meningitis and bloodstream and wound infections. The recent increase in incidence coupled with a dramatic increase in cases associated with multidrug-resistant strains has attracted significant attention to this emerging deadly pathogen. The EU-funded AgainstResistance project proposes to find novel antimicrobial targets for A. baumannii using haem-related systems to be discovered by the researchers that help bacteria to utilise iron, contributing to pathogen survival. The research will employ bioinformatics as a tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be evaluated using microbiology and biochemistry, and their contribution to infection will be tested in host–pathogen interaction assays.
Objective
The World Health Organization recently added Acinetobacter baumannii at the top of the priority list of emerging and critical pathogens, against which the number of effective antibiotics is alarmingly low. I propose to find novel antimicrobial targets for A. baumannii by discovering haem related systems that contribute to its survival. Bioinformatics will be used as a powerful tool to explore A. baumannii haem metabolism-related genes. The role of these genes will be tested through microbiology and biochemistry approaches, and their contribution to virulence will be analysed in host-pathogen interaction assays. This multidisciplinary research programme will boost my scientific skills and act as a pipeline to launch my career as an independent researcher. Furthermore, this proposal has the added value of including a custom-made training programme on leadership, management, dissemination and outreach activities. Hence, “AgainstResistance” will be the ideal framework to enhance my competences, maturity and independence as a competitive researcher, and crucial to boost my career prospects as a future group leader in the field of antimicrobial resistance, which is one of the critical current and future health challenges. The proposal will make a real difference in European excellence and competitiveness by materialising its leadership and expertise in multidrug resistance of human pathogens.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.4. - SPREADING EXCELLENCE AND WIDENING PARTICIPATION
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-WF-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1099 085 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.