Monoclonal Antibodies against 2019-New Coronavirus

Project Information

MANCO

Grant agreement ID: 101003651

DOI 10.3030/101003651

Project closed

EC signature date 7 April 2020

Start date 1 March 2020

End date 31 May 2023

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 3 034 581,25

EU contribution € 3 034 581,25

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

Deliverables

Documents, reports (1)

Communication and dissemination plan

Thisocument defines the direction of the project Communication, including the priorities, the target groups, messages, tools and resources for Communication and dissemination, as well as the organisation of both internal and external Communication by the consortium.

Publications

Peer reviewed articles (10)

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Author(s): Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Wentao Li, Nisreen M. A. Okba, Irina Albulescu, Ivy Widjaja, Brenda van Dieren, Raul Fernandez-Delgado, Isabel Sola, Daniel L. Hurdiss, Olalekan Daramola, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek, Berend-Jan Bosch
Published in: Nature Communications, Issue 12/1, 2021, Page(s) 1-15, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21968-w

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

Author(s): Federico Armando, Georg Beythien, Franziska K. Kaiser, Lisa Allnoch, Laura Heydemann, Malgorzata Rosiak, Svenja Becker, Mariana Gonzalez-Hernandez, Mart M. Lamers, Bart L. Haagmans, Kate Guilfoyle, Geert van Amerongen, Malgorzata Ciurkiewicz, Albert D.M.E. Osterhaus & Wolfgang Baumgärtner
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-31200-y

Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

Author(s): Javier Gutiérrez-Álvarez, José M. Honrubia, Raúl Fernández-Delgado, Li Wang, Carlos Castaño-Rodríguez, Sonia Zúñiga, Isabel Sola, Luis Enjuanes
Published in: mBio, Issue 12/2, 2021, ISSN 2150-7511
Publisher: mBio
DOI: 10.1128/mbio.00103-21

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

Author(s): J Gutiérrez-Álvarez 1, J M Honrubia 1, A Sanz-Bravo 1, E González-Miranda 1, R Fernández-Delgado 1, M T Rejas 2, S Zúñiga 1, I Sola 1, L Enjuanes 3
Published in: Proc Natl Acad Sci USA, Issue 10916490, 2021, ISSN 1091-6490
Publisher: Proc Natl Acad Sci USA
DOI: 10.1073/pnas.2111075118

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

Author(s): Wenjuan Du 1, Daniel L Hurdiss 1, Dubravka Drabek 2 3, Anna Z Mykytyn 4, Franziska K Kaiser 5, Mariana González-Hernández 5, Diego Muñoz-Santos 6, Mart M Lamers 4, Rien van Haperen 2 3, Wentao Li 1, Ieva Drulyte 7, Chunyan Wang 1, Isabel Sola 6, Federico Armando 8, Georg Beythien 8, Malgorzata Ciurkiewicz 8, Wolfgang Baumgärtner 8, Kate Guilfoyle 9, Tony Smits 1, Joline van der Lee 1, Frank J
Published in: Sci Immunol., Issue 24709468, 2022, ISSN 2470-9468
Publisher: Sci Immunol.
DOI: 10.1126/sciimmunol.abp9312

Nature of viruses and pandemics: Coronaviruses

Author(s): Luis Enjuanes 1, Isabel Sola 1, Sonia Zúñiga 1, José M Honrubia 1, Melissa Bello-Pérez 1, Alejandro Sanz-Bravo 1, Ezequiel González-Miranda 1, Jesús Hurtado-Tamayo 1, Ricardo Requena-Platek 1, Li Wang 1, Diego Muñoz-Santos 1, Carlos M Sánchez 1, Ana Esteban 1, Jorge Ripoll-Gómez 1
Published in: Curr Res Immunol., Issue 25902555, 2022, ISSN 2590-2555
Publisher: Curr Res Immunol.
DOI: 10.1016/j.crimmu.2022.08.003

MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral Activity

Author(s): Li Wang 1, Isabel Sola 1, Luis Enjuanes 1, Sonia Zuñiga 1
Published in: mBio, Issue 21612129, 2021, ISSN 2161-2129
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.01316-21

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

Author(s): "Lok-Yin Roy Wong # 1, Jian Zheng # 1, Kevin Wilhelmsen 2, Kun Li 3, Miguel E Ortiz 3, Nicholas J Schnicker 4, Andrew Thurman 5, Alejandro A Pezzulo 5, Peter J Szachowicz 5, Pengfei Li 1, Ruangang Pan 1, Klaus Klumpp 2, Fred Aswad 2, Justin Rebo 2, Shuh Narumiya 6, Makoto Murakami 7, Sonia Zuniga 8, Isabel Sola 8, Luis Enjuanes 8, David K Meyerholz 9, Kristen Fortney 2, Paul B McCray Jr 10 11, Stan"
Published in: Nature, Issue 14764687, 2022, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41586-022-04630-3

Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology

Author(s): Lucía Morales 1, Juan Carlos Oliveros 2, Luis Enjuanes 1, Isabel Sola 1
Published in: mBio, Issue 21612129, 2022, ISSN 2161-2129
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.03135-21

SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model.

Author(s): Haagmans, Bart L; Noack, Danny; Okba, Nisreen M A; Li, Wentao; Wang, Chunyan; Bestebroer, Theo; de Vries, Rory; Herfst, Sander; de Meulder, Dennis; Verveer, Elwin; van Run, Peter; Lamers, Mart M; Rijnders, Bart; Rokx, Casper; van Kuppeveld, Frank; Grosveld, Frank; Drabek, Dubravka; GeurtsvanKessel, Corine; Koopmans, Marion; Bosch, Berend Jan; Kuiken, Thijs; Rockx, Barry; dI&I I&I-1; Virologie
Published in: urn:issn:0022-1899, Issue 15536203, 2021, ISSN 1553-6203
Publisher: Science Publications
DOI: 10.1093/infdis/jiab289