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Monoclonal Antibodies against 2019-New Coronavirus

Risultati finali

Communication and dissemination plan

Thisocument defines the direction of the project Communication, including the priorities, the target groups, messages, tools and resources for Communication and dissemination, as well as the organisation of both internal and external Communication by the consortium.

Pubblicazioni

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Autori: Chunyan Wang, Rien van Haperen, Javier Gutiérrez-Álvarez, Wentao Li, Nisreen M. A. Okba, Irina Albulescu, Ivy Widjaja, Brenda van Dieren, Raul Fernandez-Delgado, Isabel Sola, Daniel L. Hurdiss, Olalekan Daramola, Frank Grosveld, Frank J. M. van Kuppeveld, Bart L. Haagmans, Luis Enjuanes, Dubravka Drabek, Berend-Jan Bosch
Pubblicato in: Nature Communications, Numero 12/1, 2021, Pagina/e 1-15, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21968-w

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

Autori: Federico Armando, Georg Beythien, Franziska K. Kaiser, Lisa Allnoch, Laura Heydemann, Malgorzata Rosiak, Svenja Becker, Mariana Gonzalez-Hernandez, Mart M. Lamers, Bart L. Haagmans, Kate Guilfoyle, Geert van Amerongen, Malgorzata Ciurkiewicz, Albert D.M.E. Osterhaus & Wolfgang Baumgärtner
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-31200-y

Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

Autori: Javier Gutiérrez-Álvarez, José M. Honrubia, Raúl Fernández-Delgado, Li Wang, Carlos Castaño-Rodríguez, Sonia Zúñiga, Isabel Sola, Luis Enjuanes
Pubblicato in: mBio, Numero 12/2, 2021, ISSN 2150-7511
Editore: mBio
DOI: 10.1128/mbio.00103-21

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

Autori: J Gutiérrez-Álvarez 1, J M Honrubia 1, A Sanz-Bravo 1, E González-Miranda 1, R Fernández-Delgado 1, M T Rejas 2, S Zúñiga 1, I Sola 1, L Enjuanes 3
Pubblicato in: Proc Natl Acad Sci USA, Numero 10916490, 2021, ISSN 1091-6490
Editore: Proc Natl Acad Sci USA
DOI: 10.1073/pnas.2111075118

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

Autori: Wenjuan Du 1, Daniel L Hurdiss 1, Dubravka Drabek 2 3, Anna Z Mykytyn 4, Franziska K Kaiser 5, Mariana González-Hernández 5, Diego Muñoz-Santos 6, Mart M Lamers 4, Rien van Haperen 2 3, Wentao Li 1, Ieva Drulyte 7, Chunyan Wang 1, Isabel Sola 6, Federico Armando 8, Georg Beythien 8, Malgorzata Ciurkiewicz 8, Wolfgang Baumgärtner 8, Kate Guilfoyle 9, Tony Smits 1, Joline van der Lee 1, Frank J
Pubblicato in: Sci Immunol., Numero 24709468, 2022, ISSN 2470-9468
Editore: Sci Immunol.
DOI: 10.1126/sciimmunol.abp9312

Nature of viruses and pandemics: Coronaviruses

Autori: Luis Enjuanes 1, Isabel Sola 1, Sonia Zúñiga 1, José M Honrubia 1, Melissa Bello-Pérez 1, Alejandro Sanz-Bravo 1, Ezequiel González-Miranda 1, Jesús Hurtado-Tamayo 1, Ricardo Requena-Platek 1, Li Wang 1, Diego Muñoz-Santos 1, Carlos M Sánchez 1, Ana Esteban 1, Jorge Ripoll-Gómez 1
Pubblicato in: Curr Res Immunol., Numero 25902555, 2022, ISSN 2590-2555
Editore: Curr Res Immunol.
DOI: 10.1016/j.crimmu.2022.08.003

MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral Activity

Autori: Li Wang 1, Isabel Sola 1, Luis Enjuanes 1, Sonia Zuñiga 1
Pubblicato in: mBio, Numero 21612129, 2021, ISSN 2161-2129
Editore: American Society for Microbiology
DOI: 10.1128/mbio.01316-21

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

Autori: "Lok-Yin Roy Wong # 1, Jian Zheng # 1, Kevin Wilhelmsen 2, Kun Li 3, Miguel E Ortiz 3, Nicholas J Schnicker 4, Andrew Thurman 5, Alejandro A Pezzulo 5, Peter J Szachowicz 5, Pengfei Li 1, Ruangang Pan 1, Klaus Klumpp 2, Fred Aswad 2, Justin Rebo 2, Shuh Narumiya 6, Makoto Murakami 7, Sonia Zuniga 8, Isabel Sola 8, Luis Enjuanes 8, David K Meyerholz 9, Kristen Fortney 2, Paul B McCray Jr 10 11, Stan"
Pubblicato in: Nature, Numero 14764687, 2022, ISSN 1476-4687
Editore: Nature
DOI: 10.1038/s41586-022-04630-3

Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology

Autori: Lucía Morales 1, Juan Carlos Oliveros 2, Luis Enjuanes 1, Isabel Sola 1
Pubblicato in: mBio, Numero 21612129, 2022, ISSN 2161-2129
Editore: American Society for Microbiology
DOI: 10.1128/mbio.03135-21

SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model.

Autori: Haagmans, Bart L; Noack, Danny; Okba, Nisreen M A; Li, Wentao; Wang, Chunyan; Bestebroer, Theo; de Vries, Rory; Herfst, Sander; de Meulder, Dennis; Verveer, Elwin; van Run, Peter; Lamers, Mart M; Rijnders, Bart; Rokx, Casper; van Kuppeveld, Frank; Grosveld, Frank; Drabek, Dubravka; GeurtsvanKessel, Corine; Koopmans, Marion; Bosch, Berend Jan; Kuiken, Thijs; Rockx, Barry; dI&I I&I-1; Virologie
Pubblicato in: urn:issn:0022-1899, Numero 15536203, 2021, ISSN 1553-6203
Editore: Science Publications
DOI: 10.1093/infdis/jiab289

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