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Health Initiatives in Psoriasis and PsOriatic arthritis ConsoRTium European States

Objective

Psoriatic Arthritis (PsA) is a clinically heterogeneous disease associated with diminished quality of life. Early diagnosis is challenging and prediction of natural history or therapeutic response to treatment is suboptimal: these represent critical, contemporary unmet clinical needs. HIPPOCRATES is a multi-centre consortium, with 26 world-class partners that have clinical, scientific, data analytics, ethics, patient participation and pharmaceutical industry expertise. We will address these needs. Clinical phenotypic data from multiple established, and de novo PsA cohorts combined with a unique library of bio- samples, images, and data derived therefrom, will be curated and catalogued for optimal evaluation and use. HIPPOCRATES will analyse these multi-structured datasets that traverse the disease timeline, from cutaneous psoriasis, early PsA, first therapeutic and first biologic choice. Through machine learning and other AI techniques, we will: (1) Identify molecular signals associated with the development of PsA in patients with psoriasis, so presaging PsA prevention studies; (2) Create a diagnostic algorithm for early PsA diagnosis in patients with cutaneous psoriasis or early undifferentiated inflammatory arthritis; (3) Generate biomarker algorithms, including clinical, imaging and molecular polyomic moieties, to predict disease progression and identify endotypes permitting precision treatment with existing (methotrexate, and TNF or IL-17 inhibitor) treatments and novel therapeutic regimes; (4) Elucidate the molecular basis of PsA to facilitate future drug discovery; (5) Develop diagnostic digital tools for use in clinical settings. With highly aligned academic/clinical, SME and EFPIA partners, including involvement from existing IMI programmes and competitive international associations, HIPPOCRATES will oversee the development of a sustainable infrastructure to support PsA research and improve PsA patient outcomes.

Call for proposal

H2020-JTI-IMI2-2020-20-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Address
Belfield
4 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 492 441,25

Participants (25)

UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 627 590
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 501 062,50
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
VIB VZW
Belgium
EU contribution
€ 624 261,25
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 132 945
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 448 400
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 765 426,25
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 729 686,25
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
ATTUROS LIMITED
Ireland
EU contribution
€ 675 000
Address
Drumman East Williamston Whitegate
V94 W5TV Limerick Clare
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 540 750
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 134 375
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
REGION HOVEDSTADEN
Denmark
EU contribution
€ 100 000
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 130 000
Address
Largo Gemelli 1
20123 Milano
Activity type
Higher or Secondary Education Establishments
STICHTING GROUP FOR RESEARCH AND ASSESSMENT OF PSORIASIS AND PSORIATIC ARTHRITIS EU
Netherlands
EU contribution
€ 227 500
Address
Konnetlaanje 4
1435 HW Rijsenhout
Activity type
Research Organisations
EUROPEAN LEAGUE AGAINST RHEUMATISM
Switzerland
EU contribution
€ 76 875
Address
Seestrasse 240
8802 Kilchberg
Activity type
Research Organisations
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 585 476,25
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
THE EUROPEAN INSTITUTE FOR INNOVATION THROUGH HEALTH DATA
Belgium
EU contribution
€ 225 000
Address
Oude Mechelsestraat 165
1853 Strombeek-bever
Activity type
Research Organisations
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 130 000
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
OXFORD BIODYNAMICS PLC
United Kingdom
EU contribution
€ 249 375
Address
Building 7600 C2, Alec Issigonis Wa North
OX4 2JZ Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 519 828,75
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 100 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
NEOTERYX LIMITED
United Kingdom
EU contribution
€ 195 000
Address
Victoria House Victoria Road
WA15 9AF Hale Altrincham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB BIOPHARMA
Belgium
EU contribution
€ 0
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BRISTOL-MYERS SQUIBB COMPANY CORP
United States
EU contribution
€ 0
Address
Park Avenue 345
10154 New York
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PFIZER LIMITED
United Kingdom
EU contribution
€ 0
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)